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Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis

Small-fiber neuropathy (SFN) is suggested to be involved in the pathogenesis of some types of autoimmune connective tissue diseases. SFN with a reduction in epidermal nerve fibers might affect sensory fibers and cause neuropathic symptoms, such as pruritus and pain, which are common in both dermatom...

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Autores principales: Wong, Lai-San, Lee, Chih-Hung, Yen, Yu-Ta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408946/
https://www.ncbi.nlm.nih.gov/pubmed/36012289
http://dx.doi.org/10.3390/ijms23169030
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author Wong, Lai-San
Lee, Chih-Hung
Yen, Yu-Ta
author_facet Wong, Lai-San
Lee, Chih-Hung
Yen, Yu-Ta
author_sort Wong, Lai-San
collection PubMed
description Small-fiber neuropathy (SFN) is suggested to be involved in the pathogenesis of some types of autoimmune connective tissue diseases. SFN with a reduction in epidermal nerve fibers might affect sensory fibers and cause neuropathic symptoms, such as pruritus and pain, which are common in both dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Nerve growth factor (NGF) has been recognized as important in nociception by regulating epidermal nerve fiber density and sensitizing the peripheral nervous system. The present study aimed to investigate whether SFN was associated with the cutaneous manifestations of DM and CLE. We also investigated the relationship between SFN and axon guidance molecules, such as NGF, amphiregulin (AREG), and semaphorin (Sema3A) in DM and CLE. To explore the molecular signaling, interleukin (IL)-18 and IL-31, which have been implicated in the cutaneous manifestation and neuropathic symptoms in DM, were examined in keratinocytes. Our results revealed that intraepidermal nerve fiber density (IENFD) was unchanged in patients with DM, but significantly reduced in IENFD in patients with CLE compared with healthy control. Increased epidermal expression of NGF and decreased expression of Sema3A were demonstrated in patients with DM. Furthermore, IL-18 and IL-31 both induced the production of NGF from keratinocytes. Taken together, IL-18 and IL-31 mediated epidermal NGF expression might contribute to the cutaneous neuropathic symptoms in DM, while SFN might be important for CLE.
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spelling pubmed-94089462022-08-26 Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis Wong, Lai-San Lee, Chih-Hung Yen, Yu-Ta Int J Mol Sci Article Small-fiber neuropathy (SFN) is suggested to be involved in the pathogenesis of some types of autoimmune connective tissue diseases. SFN with a reduction in epidermal nerve fibers might affect sensory fibers and cause neuropathic symptoms, such as pruritus and pain, which are common in both dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Nerve growth factor (NGF) has been recognized as important in nociception by regulating epidermal nerve fiber density and sensitizing the peripheral nervous system. The present study aimed to investigate whether SFN was associated with the cutaneous manifestations of DM and CLE. We also investigated the relationship between SFN and axon guidance molecules, such as NGF, amphiregulin (AREG), and semaphorin (Sema3A) in DM and CLE. To explore the molecular signaling, interleukin (IL)-18 and IL-31, which have been implicated in the cutaneous manifestation and neuropathic symptoms in DM, were examined in keratinocytes. Our results revealed that intraepidermal nerve fiber density (IENFD) was unchanged in patients with DM, but significantly reduced in IENFD in patients with CLE compared with healthy control. Increased epidermal expression of NGF and decreased expression of Sema3A were demonstrated in patients with DM. Furthermore, IL-18 and IL-31 both induced the production of NGF from keratinocytes. Taken together, IL-18 and IL-31 mediated epidermal NGF expression might contribute to the cutaneous neuropathic symptoms in DM, while SFN might be important for CLE. MDPI 2022-08-12 /pmc/articles/PMC9408946/ /pubmed/36012289 http://dx.doi.org/10.3390/ijms23169030 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wong, Lai-San
Lee, Chih-Hung
Yen, Yu-Ta
Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
title Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
title_full Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
title_fullStr Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
title_full_unstemmed Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
title_short Increased Epidermal Nerve Growth Factor without Small-Fiber Neuropathy in Dermatomyositis
title_sort increased epidermal nerve growth factor without small-fiber neuropathy in dermatomyositis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408946/
https://www.ncbi.nlm.nih.gov/pubmed/36012289
http://dx.doi.org/10.3390/ijms23169030
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