Cargando…

Discovery of Epipodophyllotoxin-Derived B(2) as Promising XooFtsZ Inhibitor for Controlling Bacterial Cell Division: Structure-Based Virtual Screening, Synthesis, and SAR Study

The emergence of phytopathogenic bacteria resistant to antibacterial agents has rendered previously manageable plant diseases intractable, highlighting the need for safe and environmentally responsible agrochemicals. Inhibition of bacterial cell division by targeting bacterial cell division protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Ying-Lian, Liu, Shuai-Shuai, Yang, Jie, Xie, Jiao, Zhou, Xiang, Wu, Zhi-Bing, Liu, Li-Wei, Wang, Pei-Yi, Yang, Song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408963/ https://www.ncbi.nlm.nih.gov/pubmed/36012385 http://dx.doi.org/10.3390/ijms23169119

Ejemplares similares

FtsZ-less prokaryotic cell division as well as FtsZ- and dynamin-less chloroplast and non-photosynthetic plastid division
por: Miyagishima, Shin-ya, et al.
Publicado: (2014)

The Arabidopsis thaliana chloroplast division protein FtsZ1 counterbalances FtsZ2 filament stability in vitro
por: Porter, Katie J., et al.
Publicado: (2021)

FtsZ does not initiate membrane constriction at the onset of division
por: Daley, Daniel O., et al.
Publicado: (2016)

Genetic Evidence for Inhibition of Bacterial Division Protein FtsZ by Berberine
por: Boberek, Jaroslaw M., et al.
Publicado: (2010)

Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division
por: Guan, Fenghui, et al.
Publicado: (2018)

Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ
por: Casiraghi, Andrea, et al.
Publicado: (2020)

Architecture of the ring formed by the tubulin homologue FtsZ in bacterial cell division
por: Szwedziak, Piotr, et al.
Publicado: (2014)

Life without Division: Physiology of Escherichia coli FtsZ-Deprived Filaments
por: Sánchez-Gorostiaga, Alicia, et al.
Publicado: (2016)

FtsZ of Filamentous, Heterocyst-Forming Cyanobacteria Has a Conserved N-Terminal Peptide Required for Normal FtsZ Polymerization and Cell Division
por: Corrales-Guerrero, Laura, et al.
Publicado: (2018)

Three-Dimensional Superresolution Imaging of the FtsZ Ring during Cell Division of the Cyanobacterium Prochlorococcus
por: Liu, Riyue, et al.
Publicado: (2017)

Variations in the Binding Pocket of an Inhibitor of the Bacterial Division Protein FtsZ across Genotypes and Species
por: Miguel, Amanda, et al.
Publicado: (2015)

Proteolysis-Dependent Remodeling of the Tubulin Homolog FtsZ at the Division Septum in Escherichia coli
por: Viola, Marissa G., et al.
Publicado: (2017)

Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria
por: Sekar, Karthik, et al.
Publicado: (2018)

An essential Staphylococcus aureus cell division protein directly regulates FtsZ dynamics
por: Eswara, Prahathees J, et al.
Publicado: (2018)

SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system
por: Pende, Nika, et al.
Publicado: (2021)

Comparison of in vitro activity of epipodophyllotoxins with other chemotherapeutic agents in human medulloblastomas.
por: Tomlinson, F. H., et al.
Publicado: (1991)

A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex
por: Villanelo, Felipe, et al.
Publicado: (2011)

ZapE Is a Novel Cell Division Protein Interacting with FtsZ and Modulating the Z-Ring Dynamics
por: Marteyn, Benoit S., et al.
Publicado: (2014)

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division
por: Whitley, Kevin D., et al.
Publicado: (2021)

Mycobacterium tuberculosis ClpX Interacts with FtsZ and Interferes with FtsZ Assembly
por: Dziedzic, Renata, et al.
Publicado: (2010)

Distinct functions of chloroplast FtsZ1 and FtsZ2 in Z-ring structure and remodeling
por: TerBush, Allan D., et al.
Publicado: (2012)

Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy
por: Li, Zhiru, et al.
Publicado: (2011)

Inhibition of Cell Division Induced by External Guide Sequences (EGS Technology) Targeting ftsZ
por: Sala, Carol Davies, et al.
Publicado: (2012)

The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors
por: Artola, Marta, et al.
Publicado: (2017)

Biomolecular condensate drives polymerization and bundling of the bacterial tubulin FtsZ to regulate cell division
por: Ramm, Beatrice, et al.
Publicado: (2023)

Synthesis of (−)−deoxypodophyllotoxin and (−)−epipodophyllotoxin via a multi-enzyme cascade in E. coli
por: Decembrino, Davide, et al.
Publicado: (2021)

ZipA Binds to FtsZ with High Affinity and Enhances the Stability of FtsZ Protofilaments
por: Kuchibhatla, Anuradha, et al.
Publicado: (2011)

Dr-FtsA, an Actin Homologue in Deinococcus radiodurans Differentially Affects Dr-FtsZ and Ec-FtsZ Functions In Vitro
por: Modi, Kruti, et al.
Publicado: (2014)

Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ
por: Pilhofer, Martin, et al.
Publicado: (2013)

The conserved actinobacterial transcriptional regulator FtsR controls expression of ftsZ and further target genes and influences growth and cell division in Corynebacterium glutamicum
por: Kraxner, Kim Julia, et al.
Publicado: (2019)

The Stress-Active Cell Division Protein ZapE Alters FtsZ Filament Architecture to Facilitate Division in Escherichia coli
por: DiBiasio, Eric C., et al.
Publicado: (2021)

Streptococcus suis MsmK: Novel Cell Division Protein Interacting with FtsZ and Maintaining Cell Shape
por: Tan, Mei-Fang, et al.
Publicado: (2021)

Novel Role of Phosphorylation-Dependent Interaction between FtsZ and FipA in Mycobacterial Cell Division
por: Sureka, Kamakshi, et al.
Publicado: (2010)

Metal-dependent SpoIIE oligomerization stabilizes FtsZ during asymmetric division in Bacillus subtilis
por: Cendrowicz, Ewa, et al.
Publicado: (2017)

Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
por: Silber, Nadine, et al.
Publicado: (2020)

The Antitumor Agent Ansamitocin P-3 Binds to Cell Division Protein FtsZ in Actinosynnema pretiosum
por: Wang, Xinran, et al.
Publicado: (2020)

Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins
por: Baranova, Natalia, et al.
Publicado: (2020)

A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria
por: Ramos-León, Félix, et al.
Publicado: (2021)

ZipA Uses a Two-Pronged FtsZ-Binding Mechanism Necessary for Cell Division
por: Cameron, Todd A., et al.
Publicado: (2021)

ZipA and FtsA* stabilize FtsZ-GDP miniring structures
por: Chen, Yaodong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ob3bp64kfkk9qe560ee8942e6s