Cargando…

The Link between Gut Microbiota and Hepatic Encephalopathy

Hepatic encephalopathy (HE) is a serious complication of cirrhosis that causes neuropsychiatric problems, such as cognitive dysfunction and movement disorders. The link between the microbiota and the host plays a key role in the pathogenesis of HE. The link between the gut microbiome and disease can...

Descripción completa

Detalles Bibliográficos
Autores principales: Won, Sung-Min, Oh, Ki Kwang, Gupta, Haripriya, Ganesan, Raja, Sharma, Satya Priya, Jeong, Jin-Ju, Yoon, Sang Jun, Jeong, Min Kyo, Min, Byeong Hyun, Hyun, Ji Ye, Park, Hee Jin, Eom, Jung A., Lee, Su Been, Cha, Min Gi, Kwon, Goo Hyun, Choi, Mi Ran, Kim, Dong Joon, Suk, Ki Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408988/
https://www.ncbi.nlm.nih.gov/pubmed/36012266
http://dx.doi.org/10.3390/ijms23168999
_version_ 1784774738569068544
author Won, Sung-Min
Oh, Ki Kwang
Gupta, Haripriya
Ganesan, Raja
Sharma, Satya Priya
Jeong, Jin-Ju
Yoon, Sang Jun
Jeong, Min Kyo
Min, Byeong Hyun
Hyun, Ji Ye
Park, Hee Jin
Eom, Jung A.
Lee, Su Been
Cha, Min Gi
Kwon, Goo Hyun
Choi, Mi Ran
Kim, Dong Joon
Suk, Ki Tae
author_facet Won, Sung-Min
Oh, Ki Kwang
Gupta, Haripriya
Ganesan, Raja
Sharma, Satya Priya
Jeong, Jin-Ju
Yoon, Sang Jun
Jeong, Min Kyo
Min, Byeong Hyun
Hyun, Ji Ye
Park, Hee Jin
Eom, Jung A.
Lee, Su Been
Cha, Min Gi
Kwon, Goo Hyun
Choi, Mi Ran
Kim, Dong Joon
Suk, Ki Tae
author_sort Won, Sung-Min
collection PubMed
description Hepatic encephalopathy (HE) is a serious complication of cirrhosis that causes neuropsychiatric problems, such as cognitive dysfunction and movement disorders. The link between the microbiota and the host plays a key role in the pathogenesis of HE. The link between the gut microbiome and disease can be positively utilized not only in the diagnosis area of HE but also in the treatment area. Probiotics and prebiotics aim to resolve gut dysbiosis and increase beneficial microbial taxa, while fecal microbiota transplantation aims to address gut dysbiosis through transplantation (FMT) of the gut microbiome from healthy donors. Antibiotics, such as rifaximin, aim to improve cognitive function and hyperammonemia by targeting harmful taxa. Current treatment regimens for HE have achieved some success in treatment by targeting the gut microbiota, however, are still accompanied by limitations and problems. A focused approach should be placed on the establishment of personalized trial designs and therapies for the improvement of future care. This narrative review identifies factors negatively influencing the gut–hepatic–brain axis leading to HE in cirrhosis and explores their relationship with the gut microbiome. We also focused on the evaluation of reported clinical studies on the management and improvement of HE patients with a particular focus on microbiome-targeted therapy.
format Online
Article
Text
id pubmed-9408988
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94089882022-08-26 The Link between Gut Microbiota and Hepatic Encephalopathy Won, Sung-Min Oh, Ki Kwang Gupta, Haripriya Ganesan, Raja Sharma, Satya Priya Jeong, Jin-Ju Yoon, Sang Jun Jeong, Min Kyo Min, Byeong Hyun Hyun, Ji Ye Park, Hee Jin Eom, Jung A. Lee, Su Been Cha, Min Gi Kwon, Goo Hyun Choi, Mi Ran Kim, Dong Joon Suk, Ki Tae Int J Mol Sci Review Hepatic encephalopathy (HE) is a serious complication of cirrhosis that causes neuropsychiatric problems, such as cognitive dysfunction and movement disorders. The link between the microbiota and the host plays a key role in the pathogenesis of HE. The link between the gut microbiome and disease can be positively utilized not only in the diagnosis area of HE but also in the treatment area. Probiotics and prebiotics aim to resolve gut dysbiosis and increase beneficial microbial taxa, while fecal microbiota transplantation aims to address gut dysbiosis through transplantation (FMT) of the gut microbiome from healthy donors. Antibiotics, such as rifaximin, aim to improve cognitive function and hyperammonemia by targeting harmful taxa. Current treatment regimens for HE have achieved some success in treatment by targeting the gut microbiota, however, are still accompanied by limitations and problems. A focused approach should be placed on the establishment of personalized trial designs and therapies for the improvement of future care. This narrative review identifies factors negatively influencing the gut–hepatic–brain axis leading to HE in cirrhosis and explores their relationship with the gut microbiome. We also focused on the evaluation of reported clinical studies on the management and improvement of HE patients with a particular focus on microbiome-targeted therapy. MDPI 2022-08-12 /pmc/articles/PMC9408988/ /pubmed/36012266 http://dx.doi.org/10.3390/ijms23168999 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Won, Sung-Min
Oh, Ki Kwang
Gupta, Haripriya
Ganesan, Raja
Sharma, Satya Priya
Jeong, Jin-Ju
Yoon, Sang Jun
Jeong, Min Kyo
Min, Byeong Hyun
Hyun, Ji Ye
Park, Hee Jin
Eom, Jung A.
Lee, Su Been
Cha, Min Gi
Kwon, Goo Hyun
Choi, Mi Ran
Kim, Dong Joon
Suk, Ki Tae
The Link between Gut Microbiota and Hepatic Encephalopathy
title The Link between Gut Microbiota and Hepatic Encephalopathy
title_full The Link between Gut Microbiota and Hepatic Encephalopathy
title_fullStr The Link between Gut Microbiota and Hepatic Encephalopathy
title_full_unstemmed The Link between Gut Microbiota and Hepatic Encephalopathy
title_short The Link between Gut Microbiota and Hepatic Encephalopathy
title_sort link between gut microbiota and hepatic encephalopathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9408988/
https://www.ncbi.nlm.nih.gov/pubmed/36012266
http://dx.doi.org/10.3390/ijms23168999
work_keys_str_mv AT wonsungmin thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT ohkikwang thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT guptaharipriya thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT ganesanraja thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT sharmasatyapriya thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT jeongjinju thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT yoonsangjun thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT jeongminkyo thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT minbyeonghyun thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT hyunjiye thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT parkheejin thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT eomjunga thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT leesubeen thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT chamingi thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT kwongoohyun thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT choimiran thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT kimdongjoon thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT sukkitae thelinkbetweengutmicrobiotaandhepaticencephalopathy
AT wonsungmin linkbetweengutmicrobiotaandhepaticencephalopathy
AT ohkikwang linkbetweengutmicrobiotaandhepaticencephalopathy
AT guptaharipriya linkbetweengutmicrobiotaandhepaticencephalopathy
AT ganesanraja linkbetweengutmicrobiotaandhepaticencephalopathy
AT sharmasatyapriya linkbetweengutmicrobiotaandhepaticencephalopathy
AT jeongjinju linkbetweengutmicrobiotaandhepaticencephalopathy
AT yoonsangjun linkbetweengutmicrobiotaandhepaticencephalopathy
AT jeongminkyo linkbetweengutmicrobiotaandhepaticencephalopathy
AT minbyeonghyun linkbetweengutmicrobiotaandhepaticencephalopathy
AT hyunjiye linkbetweengutmicrobiotaandhepaticencephalopathy
AT parkheejin linkbetweengutmicrobiotaandhepaticencephalopathy
AT eomjunga linkbetweengutmicrobiotaandhepaticencephalopathy
AT leesubeen linkbetweengutmicrobiotaandhepaticencephalopathy
AT chamingi linkbetweengutmicrobiotaandhepaticencephalopathy
AT kwongoohyun linkbetweengutmicrobiotaandhepaticencephalopathy
AT choimiran linkbetweengutmicrobiotaandhepaticencephalopathy
AT kimdongjoon linkbetweengutmicrobiotaandhepaticencephalopathy
AT sukkitae linkbetweengutmicrobiotaandhepaticencephalopathy