Cargando…

Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans

Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecula...

Descripción completa

Detalles Bibliográficos
Autor principal: von Mikecz, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409025/
https://www.ncbi.nlm.nih.gov/pubmed/36012346
http://dx.doi.org/10.3390/ijms23169084
_version_ 1784774748409954304
author von Mikecz, Anna
author_facet von Mikecz, Anna
author_sort von Mikecz, Anna
collection PubMed
description Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecular mechanisms of the biological response to nanomaterials. With an estimated number of 22,000 coding genes and short life span of 2–3 weeks, the small worm is a giant when it comes to characterization of molecular pathways, long-term low dose pollutant effects and vulnerable age-groups. Here, we review (i) flows of manufactured nanomaterials and exposition of C. elegans in the environment, (ii) the track record of C. elegans in biomedical research, and (iii) its potential to contribute to the investigation of the exposome and bridge nanotoxicology between higher organisms, including humans. The role of C. elegans in the one health concept is taken one step further by proposing methods to sample wild nematodes and their molecular characterization by single worm proteomics.
format Online
Article
Text
id pubmed-9409025
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94090252022-08-26 Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans von Mikecz, Anna Int J Mol Sci Review Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecular mechanisms of the biological response to nanomaterials. With an estimated number of 22,000 coding genes and short life span of 2–3 weeks, the small worm is a giant when it comes to characterization of molecular pathways, long-term low dose pollutant effects and vulnerable age-groups. Here, we review (i) flows of manufactured nanomaterials and exposition of C. elegans in the environment, (ii) the track record of C. elegans in biomedical research, and (iii) its potential to contribute to the investigation of the exposome and bridge nanotoxicology between higher organisms, including humans. The role of C. elegans in the one health concept is taken one step further by proposing methods to sample wild nematodes and their molecular characterization by single worm proteomics. MDPI 2022-08-13 /pmc/articles/PMC9409025/ /pubmed/36012346 http://dx.doi.org/10.3390/ijms23169084 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
von Mikecz, Anna
Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
title Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
title_full Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
title_fullStr Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
title_full_unstemmed Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
title_short Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
title_sort exposome, molecular pathways and one health: the invertebrate caenorhabditis elegans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409025/
https://www.ncbi.nlm.nih.gov/pubmed/36012346
http://dx.doi.org/10.3390/ijms23169084
work_keys_str_mv AT vonmikeczanna exposomemolecularpathwaysandonehealththeinvertebratecaenorhabditiselegans