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Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans
Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecula...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409025/ https://www.ncbi.nlm.nih.gov/pubmed/36012346 http://dx.doi.org/10.3390/ijms23169084 |
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author | von Mikecz, Anna |
author_facet | von Mikecz, Anna |
author_sort | von Mikecz, Anna |
collection | PubMed |
description | Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecular mechanisms of the biological response to nanomaterials. With an estimated number of 22,000 coding genes and short life span of 2–3 weeks, the small worm is a giant when it comes to characterization of molecular pathways, long-term low dose pollutant effects and vulnerable age-groups. Here, we review (i) flows of manufactured nanomaterials and exposition of C. elegans in the environment, (ii) the track record of C. elegans in biomedical research, and (iii) its potential to contribute to the investigation of the exposome and bridge nanotoxicology between higher organisms, including humans. The role of C. elegans in the one health concept is taken one step further by proposing methods to sample wild nematodes and their molecular characterization by single worm proteomics. |
format | Online Article Text |
id | pubmed-9409025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94090252022-08-26 Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans von Mikecz, Anna Int J Mol Sci Review Due to its preferred habitats in the environment, the free-living nematode Caenorhabditis elegans has become a realistic target organism for pollutants, including manufactured nanoparticles. In the laboratory, the invertebrate animal model represents a cost-effective tool to investigate the molecular mechanisms of the biological response to nanomaterials. With an estimated number of 22,000 coding genes and short life span of 2–3 weeks, the small worm is a giant when it comes to characterization of molecular pathways, long-term low dose pollutant effects and vulnerable age-groups. Here, we review (i) flows of manufactured nanomaterials and exposition of C. elegans in the environment, (ii) the track record of C. elegans in biomedical research, and (iii) its potential to contribute to the investigation of the exposome and bridge nanotoxicology between higher organisms, including humans. The role of C. elegans in the one health concept is taken one step further by proposing methods to sample wild nematodes and their molecular characterization by single worm proteomics. MDPI 2022-08-13 /pmc/articles/PMC9409025/ /pubmed/36012346 http://dx.doi.org/10.3390/ijms23169084 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review von Mikecz, Anna Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans |
title | Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans |
title_full | Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans |
title_fullStr | Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans |
title_full_unstemmed | Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans |
title_short | Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans |
title_sort | exposome, molecular pathways and one health: the invertebrate caenorhabditis elegans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409025/ https://www.ncbi.nlm.nih.gov/pubmed/36012346 http://dx.doi.org/10.3390/ijms23169084 |
work_keys_str_mv | AT vonmikeczanna exposomemolecularpathwaysandonehealththeinvertebratecaenorhabditiselegans |