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The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer

Currently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA tra...

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Autores principales: Kipkeeva, Fatimat, Muzaffarova, Tatyana, Korotaeva, Alexandra, Mansorunov, Danzan, Apanovich, Pavel, Nikulin, Maxim, Malikhova, Olga, Stilidi, Ivan, Karpukhin, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409052/
https://www.ncbi.nlm.nih.gov/pubmed/36012588
http://dx.doi.org/10.3390/ijms23169324
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author Kipkeeva, Fatimat
Muzaffarova, Tatyana
Korotaeva, Alexandra
Mansorunov, Danzan
Apanovich, Pavel
Nikulin, Maxim
Malikhova, Olga
Stilidi, Ivan
Karpukhin, Alexander
author_facet Kipkeeva, Fatimat
Muzaffarova, Tatyana
Korotaeva, Alexandra
Mansorunov, Danzan
Apanovich, Pavel
Nikulin, Maxim
Malikhova, Olga
Stilidi, Ivan
Karpukhin, Alexander
author_sort Kipkeeva, Fatimat
collection PubMed
description Currently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA translation. An important feature of miRNA is its ability to affect the expression of several genes simultaneously, which corresponds to the trend toward the use of combination therapy. The article provides a list of miRNAs acting simultaneously on several ICs and miRNAs that, in addition to IC, can regulate the expression of targeted therapy genes. There is dependence of miRNA interactions with IC genes on the type of cancer. The analysis of the accumulated data demonstrates that only about 14% (95% CI: 9.8–20.1%) of the studied miRNAs regulate the expression of specific IC in more than one type of cancer. That is, there is tumor specificity in the miRNA action on ICs. A number of miRNAs demonstrated high efficiency in vitro and in vivo. This indicates the potential of miRNAs as promising agents for cancer immunotherapy. Additional studies of the miRNA–gene interaction features and the search for an optimal miRNA mimic structure are necessary.
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spelling pubmed-94090522022-08-26 The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer Kipkeeva, Fatimat Muzaffarova, Tatyana Korotaeva, Alexandra Mansorunov, Danzan Apanovich, Pavel Nikulin, Maxim Malikhova, Olga Stilidi, Ivan Karpukhin, Alexander Int J Mol Sci Review Currently, the search for new promising tools of immunotherapy continues. In this regard, microRNAs (miRNAs) that influence immune checkpoint (IC) gene expression in tumor and T-cells and may be important regulators of immune cells are considered. MiRNAs regulate gene expression by blocking mRNA translation. An important feature of miRNA is its ability to affect the expression of several genes simultaneously, which corresponds to the trend toward the use of combination therapy. The article provides a list of miRNAs acting simultaneously on several ICs and miRNAs that, in addition to IC, can regulate the expression of targeted therapy genes. There is dependence of miRNA interactions with IC genes on the type of cancer. The analysis of the accumulated data demonstrates that only about 14% (95% CI: 9.8–20.1%) of the studied miRNAs regulate the expression of specific IC in more than one type of cancer. That is, there is tumor specificity in the miRNA action on ICs. A number of miRNAs demonstrated high efficiency in vitro and in vivo. This indicates the potential of miRNAs as promising agents for cancer immunotherapy. Additional studies of the miRNA–gene interaction features and the search for an optimal miRNA mimic structure are necessary. MDPI 2022-08-18 /pmc/articles/PMC9409052/ /pubmed/36012588 http://dx.doi.org/10.3390/ijms23169324 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kipkeeva, Fatimat
Muzaffarova, Tatyana
Korotaeva, Alexandra
Mansorunov, Danzan
Apanovich, Pavel
Nikulin, Maxim
Malikhova, Olga
Stilidi, Ivan
Karpukhin, Alexander
The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
title The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
title_full The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
title_fullStr The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
title_full_unstemmed The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
title_short The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer
title_sort features of immune checkpoint gene regulation by microrna in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409052/
https://www.ncbi.nlm.nih.gov/pubmed/36012588
http://dx.doi.org/10.3390/ijms23169324
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