Cargando…

Targeting NLRP3-Mediated Neuroinflammation in Alzheimer’s Disease Treatment

Alzheimer’s disease (AD) is the most common cause of dementia in the general population and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD, aggregates of amyloid β (Aβ) and neurofibrillary tangles (NFTs) containing Tau-microtubule-associated protein (tau) are known to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barczuk, Julia, Siwecka, Natalia, Lusa, Weronika, Rozpędek-Kamińska, Wioletta, Kucharska, Ewa, Majsterek, Ireneusz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409081/ https://www.ncbi.nlm.nih.gov/pubmed/36012243 http://dx.doi.org/10.3390/ijms23168979

Ejemplares similares

GBA1 Gene Mutations in α-Synucleinopathies—Molecular Mechanisms Underlying Pathology and Their Clinical Significance
por: Granek, Zuzanna, et al.
Publicado: (2023)

IRE1α Inhibitors as a Promising Therapeutic Strategy in Blood Malignancies
por: Wiese, Wojciech, et al.
Publicado: (2022)

PI3K/Akt/mTOR Signaling Pathway in Blood Malignancies—New Therapeutic Possibilities
por: Wiese, Wojciech, et al.
Publicado: (2023)

Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy
por: Siwecka, Natalia, et al.
Publicado: (2023)

The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment
por: Rozpędek-Kamińska, Wioletta, et al.
Publicado: (2021)

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
por: Rozpędek-Kamińska, Wioletta, et al.
Publicado: (2020)

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
por: Siwecka, Natalia, et al.
Publicado: (2021)

Molecular Mechanisms Underlying NMDARs Dysfunction and Their Role in ADHD Pathogenesis
por: Kuś, Justyna, et al.
Publicado: (2023)

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis
por: Siwecka, Natalia, et al.
Publicado: (2019)

The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma
por: Rozpędek-Kamińska, Wioletta, et al.
Publicado: (2020)

Synthesis and Hemostatic Activity of New Amide Derivatives
por: Banach, Lukasz, et al.
Publicado: (2022)

The Cytotoxicity and Genotoxicity of Three Dental Universal Adhesives—An In Vitro Study
por: Wawrzynkiewicz, Adam, et al.
Publicado: (2020)

The Toxicity of Universal Dental Adhesives: An In Vitro Study
por: Wawrzynkiewicz, Adam, et al.
Publicado: (2021)

The Cytotoxicity and Genotoxicity of Bioactive Dental Materials
por: Kunert, Marta, et al.
Publicado: (2022)

Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration—Neurodegenerative Disease
por: Mrowicka, Małgorzata, et al.
Publicado: (2022)

Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis
por: Basak, Justyna, et al.
Publicado: (2022)

Association of miRNA and mRNA Levels of the Clinical Onset of Multiple Sclerosis Patients
por: Piotrzkowska, Danuta, et al.
Publicado: (2021)

RNA-Based Liquid Biopsy in Head and Neck Cancer
por: Kabzinski, Jacek, et al.
Publicado: (2023)

A Novel Treatment Strategy by Natural Products in NLRP3 Inflammasome-Mediated Neuroinflammation in Alzheimer’s and Parkinson’s Disease
por: Lee, Jun Ho, et al.
Publicado: (2021)

Association between the Cytosine Hydroxymethylation and the Expression of microRNA in Multiple Sclerosis in Polish Population
por: Basak, Justyna, et al.
Publicado: (2023)

Exploring the mRNA and Plasma Protein Levels of BDNF, NT4, SIRT1, HSP27, and HSP70 in Multiple Sclerosis Patients and Healthy Controls
por: Sokolowski, Igor, et al.
Publicado: (2023)

Physico-Chemical Properties and Biocompatibility of Thermosensitive Chitosan Lactate and Chitosan Chloride Hydrogels Developed for Tissue Engineering Application
por: Pieklarz, Katarzyna, et al.
Publicado: (2021)

Targeting neuroinflammation in Alzheimer’s disease
por: Bronzuoli, Maria Rosanna, et al.
Publicado: (2016)

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis
por: Kaushik, Deepak Kumar, et al.
Publicado: (2012)

TARGETING THE NLRP3 INFLAMMASOME IN MECHANISMS OF SLEEP DEPRIVATION-INDUCED NEUROINFLAMMATION
por: Smith, Chad, et al.
Publicado: (2019)

Targeting Neuroinflammation to Treat Alzheimer’s Disease
por: Ardura-Fabregat, A., et al.
Publicado: (2017)

The Role of Exosomes as Mediators of Neuroinflammation in the Pathogenesis and Treatment of Alzheimer’s Disease
por: Weng, Shiting, et al.
Publicado: (2022)

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia
por: Zhang, Yahui, et al.
Publicado: (2021)

GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
por: Qin, Zhangjin, et al.
Publicado: (2022)

NLRP3 Inflammasome-Mediated Neuroinflammation and Related Mitochondrial Impairment in Parkinson’s Disease
por: Han, Qiu-Qin, et al.
Publicado: (2023)

New cyclopentaquinoline hybrids with multifunctional capacities for the treatment of Alzheimer’s disease
por: Czarnecka, Kamila, et al.
Publicado: (2017)

Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease
por: Yang, Seung-Hoon
Publicado: (2019)

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease
por: Al-Ghraiybah, Nour F., et al.
Publicado: (2022)

Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3/caspase-1 pathway in Alzheimer’s disease
por: Liu, Guang-Zhi, et al.
Publicado: (2023)

Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis
por: Cai, Yawen, et al.
Publicado: (2022)

lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation
por: Xue, Zhenyi, et al.
Publicado: (2018)

Editorial: The NLRP3 inflammasome-mediated neuroinflammation and its related mitochondrial impairment in neurodegeneration
por: Deng, Chao, et al.
Publicado: (2023)

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease
por: Czarnecka, Kamila, et al.
Publicado: (2019)

Neuroinflammation as a Potential Therapeutic Target in Alzheimer’s Disease
por: Liu, Ping, et al.
Publicado: (2022)

Secondary White Matter Injury Mediated by Neuroinflammation after Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome
por: Xiao, Linglong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j21994tnv7tjqnqamgbumm2rp8