Cargando…

The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation

Diabetic kidney disease (DKD) can cause inflammation and fibrosis, in addition to being the main complication of diabetes. Among many factors, epigenetic alterations in aberrant histone modifications play a key role in causing DKD. In this study, the mechanism of GSK-J4, a histone demethylase KDM6A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hung, Peir-Haur, Hsu, Yung-Chien, Chen, Tsung-Hsien, Ho, Cheng, Lin, Chun-Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409090/ https://www.ncbi.nlm.nih.gov/pubmed/36012674 http://dx.doi.org/10.3390/ijms23169407

Ejemplares similares

Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis
por: Hung, Peir-Haur, et al.
Publicado: (2021)

The pharmacological role of histone demethylase JMJD3 inhibitor GSK-J4 on glioma cells
por: Sui, Aixia, et al.
Publicado: (2017)

Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
por: Li, Yunan, et al.
Publicado: (2018)

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model
por: Wang, Jing-Jing, et al.
Publicado: (2022)

Urolithiasis Is a Risk Factor for Uroseptic Shock and Acute Kidney Injury in Patients With Urinary Tract Infection
por: Hsiao, Chih-Yen, et al.
Publicado: (2019)

Therapeutic effect of a histone demethylase inhibitor in Parkinson’s disease
por: Mu, Ming-Dao, et al.
Publicado: (2020)

Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury
por: Pan, Heng-Chih, et al.
Publicado: (2022)

Clinical burden of autosomal dominant polycystic kidney disease
por: Hung, Peir-Haur, et al.
Publicado: (2020)

Possible Pathogenesis and Prevention of Long COVID: SARS-CoV-2-Induced Mitochondrial Disorder
por: Chen, Tsung-Hsien, et al.
Publicado: (2023)

Knockout of KLF10 Ameliorated Diabetic Renal Fibrosis via Downregulation of DKK-1
por: Hsu, Yung-Chien, et al.
Publicado: (2022)

Methylation Patterns of DKK1, DKK3 and GSK3β Are Accompanied with Different Expression Levels in Human Astrocytoma
por: Kafka, Anja, et al.
Publicado: (2021)

Histone Demethylase LSD1 Regulates Kidney Cancer Progression by Modulating Androgen Receptor Activity
por: Lee, Kyoung-Hwa, et al.
Publicado: (2020)

Long-term exposure to air pollutants and increased risk of chronic kidney disease in a community-based population using a fuzzy logic inference model
por: Lin, Hsueh-Chun, et al.
Publicado: (2022)

Fibrosis—the tale of H3K27 histone methyltransferases and demethylases
por: Basta, Morgan D., et al.
Publicado: (2023)

Risk Factors for Development of Acute Kidney Injury in Patients with Urinary Tract Infection
por: Hsiao, Chih-Yen, et al.
Publicado: (2015)

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis
por: Xu, Kai, et al.
Publicado: (2022)

Epigenetic Control and Cancer: The Potential of Histone Demethylases as Therapeutic Targets
por: Lizcano, Fernando, et al.
Publicado: (2012)

Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer
por: Morozov, Viacheslav M., et al.
Publicado: (2017)

Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure
por: Feng, Shaozhen, et al.
Publicado: (2022)

Glycated Hemoglobin < 6.5% Is Associated With Uroseptic Shock in Diabetic Patients With Urinary Tract Infection
por: Lee, Yi-Chien, et al.
Publicado: (2020)

Histone demethylase lysine demethylase 5B in development and cancer
por: Han, Mengjiao, et al.
Publicado: (2016)

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells
por: Doñas, Cristian, et al.
Publicado: (2021)

GSK-J4 Inhibition of KDM6B Histone Demethylase Blocks Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells by Modulating NF-κB Signaling
por: Sadeghi, Laia, et al.
Publicado: (2023)

Infections and risk of end-stage renal disease in patients with nephrotic syndrome: a nationwide population-based case-control study
por: Lin, Chien-Hung, et al.
Publicado: (2020)

Involvement of MicroRNA-296 in the Inhibitory Effect of Epigallocatechin Gallate against the Migratory Properties of Anoikis-Resistant Nasopharyngeal Carcinoma Cells
por: Lin, Chien-Hung, et al.
Publicado: (2020)

Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
por: Chen, Jia-Huang, et al.
Publicado: (2021)

Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production
por: Liao, Hung-Wei, et al.
Publicado: (2019)

Risk factors for uroseptic shock in hospitalized patients aged over 80 years with urinary tract infection
por: Hsiao, Chih-Yen, et al.
Publicado: (2020)

Essential Functions of the Histone Demethylase Lid
por: Li, Ling, et al.
Publicado: (2010)

Histone demethylases in chromatin biology and beyond
por: Dimitrova, Emilia, et al.
Publicado: (2015)

Histone lysine demethylases in Drosophila melanogaster
por: Holowatyj, Andreana, et al.
Publicado: (2015)

Histone demethylases in the regulation of immunity and inflammation
por: Qu, Lihua, et al.
Publicado: (2023)

Assessing histone demethylase inhibitors in cells: lessons learned
por: Hatch, Stephanie B., et al.
Publicado: (2017)

Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
por: Yu, Chao, et al.
Publicado: (2019)

The antischistosomal potential of GSK-J4, an H3K27 demethylase inhibitor: insights from molecular modeling, transcriptomics and in vitro assays
por: Lobo-Silva, Jessica, et al.
Publicado: (2020)

GSK3β and the aging kidney
por: Kreidberg, Jordan A., et al.
Publicado: (2022)

Advances in Histone Demethylase KDM3A as a Cancer Therapeutic Target
por: Yoo, Jung, et al.
Publicado: (2020)

Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy
por: Jose, Anmi, et al.
Publicado: (2020)

CD44 Is Associated with the Aggressive Phenotype of Nasopharyngeal Carcinoma through Redox Regulation
por: Lin, Chien-Hung, et al.
Publicado: (2013)

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
por: Zhang, Qing-Jun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_k1mi3f21ipslnb3jrqsjkbes9a