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Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases
It is estimated that up to 80% of the human genome is transcribed into RNA molecules but less than 2% of the genome encodes the proteins, and the rest of the RNA transcripts that are not translated into protein are called non-coding RNAs (ncRNAs). Many studies have revealed that ncRNAs have biochemi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409130/ https://www.ncbi.nlm.nih.gov/pubmed/36012216 http://dx.doi.org/10.3390/ijms23168950 |
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author | Park, Eun Gyung Ha, Hongseok Lee, Du Hyeong Kim, Woo Ryung Lee, Yun Ju Bae, Woo Hyeon Kim, Heui-Soo |
author_facet | Park, Eun Gyung Ha, Hongseok Lee, Du Hyeong Kim, Woo Ryung Lee, Yun Ju Bae, Woo Hyeon Kim, Heui-Soo |
author_sort | Park, Eun Gyung |
collection | PubMed |
description | It is estimated that up to 80% of the human genome is transcribed into RNA molecules but less than 2% of the genome encodes the proteins, and the rest of the RNA transcripts that are not translated into protein are called non-coding RNAs (ncRNAs). Many studies have revealed that ncRNAs have biochemical activities as epigenetic regulators at the post-transcriptional level. Growing evidence has demonstrated that transposable elements (TEs) contribute to a large percentage of ncRNAs’ transcription. The TEs inserted into certain parts of the genome can act as alternative promoters, enhancers, and insulators, and the accumulation of TEs increases genetic diversity in the human genome. The TEs can also generate microRNAs, so-called miRNA-derived from transposable elements (MDTEs), and are also implicated in disease progression, such as infectious diseases and cancer. Here, we analyzed the origin of ncRNAs and reviewed the published literature on MDTEs related to disease progression. |
format | Online Article Text |
id | pubmed-9409130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94091302022-08-26 Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases Park, Eun Gyung Ha, Hongseok Lee, Du Hyeong Kim, Woo Ryung Lee, Yun Ju Bae, Woo Hyeon Kim, Heui-Soo Int J Mol Sci Review It is estimated that up to 80% of the human genome is transcribed into RNA molecules but less than 2% of the genome encodes the proteins, and the rest of the RNA transcripts that are not translated into protein are called non-coding RNAs (ncRNAs). Many studies have revealed that ncRNAs have biochemical activities as epigenetic regulators at the post-transcriptional level. Growing evidence has demonstrated that transposable elements (TEs) contribute to a large percentage of ncRNAs’ transcription. The TEs inserted into certain parts of the genome can act as alternative promoters, enhancers, and insulators, and the accumulation of TEs increases genetic diversity in the human genome. The TEs can also generate microRNAs, so-called miRNA-derived from transposable elements (MDTEs), and are also implicated in disease progression, such as infectious diseases and cancer. Here, we analyzed the origin of ncRNAs and reviewed the published literature on MDTEs related to disease progression. MDPI 2022-08-11 /pmc/articles/PMC9409130/ /pubmed/36012216 http://dx.doi.org/10.3390/ijms23168950 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Eun Gyung Ha, Hongseok Lee, Du Hyeong Kim, Woo Ryung Lee, Yun Ju Bae, Woo Hyeon Kim, Heui-Soo Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases |
title | Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases |
title_full | Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases |
title_fullStr | Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases |
title_full_unstemmed | Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases |
title_short | Genomic Analyses of Non-Coding RNAs Overlapping Transposable Elements and Its Implication to Human Diseases |
title_sort | genomic analyses of non-coding rnas overlapping transposable elements and its implication to human diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409130/ https://www.ncbi.nlm.nih.gov/pubmed/36012216 http://dx.doi.org/10.3390/ijms23168950 |
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