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Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease

Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver...

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Autores principales: Ravaioli, Federico, Pivetti, Alessandra, Di Marco, Lorenza, Chrysanthi, Christou, Frassanito, Gabriella, Pambianco, Martina, Sicuro, Chiara, Gualandi, Noemi, Guasconi, Tomas, Pecchini, Maddalena, Colecchia, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409132/
https://www.ncbi.nlm.nih.gov/pubmed/36012285
http://dx.doi.org/10.3390/ijms23169016
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author Ravaioli, Federico
Pivetti, Alessandra
Di Marco, Lorenza
Chrysanthi, Christou
Frassanito, Gabriella
Pambianco, Martina
Sicuro, Chiara
Gualandi, Noemi
Guasconi, Tomas
Pecchini, Maddalena
Colecchia, Antonio
author_facet Ravaioli, Federico
Pivetti, Alessandra
Di Marco, Lorenza
Chrysanthi, Christou
Frassanito, Gabriella
Pambianco, Martina
Sicuro, Chiara
Gualandi, Noemi
Guasconi, Tomas
Pecchini, Maddalena
Colecchia, Antonio
author_sort Ravaioli, Federico
collection PubMed
description Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease.
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spelling pubmed-94091322022-08-26 Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease Ravaioli, Federico Pivetti, Alessandra Di Marco, Lorenza Chrysanthi, Christou Frassanito, Gabriella Pambianco, Martina Sicuro, Chiara Gualandi, Noemi Guasconi, Tomas Pecchini, Maddalena Colecchia, Antonio Int J Mol Sci Review Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease. MDPI 2022-08-12 /pmc/articles/PMC9409132/ /pubmed/36012285 http://dx.doi.org/10.3390/ijms23169016 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ravaioli, Federico
Pivetti, Alessandra
Di Marco, Lorenza
Chrysanthi, Christou
Frassanito, Gabriella
Pambianco, Martina
Sicuro, Chiara
Gualandi, Noemi
Guasconi, Tomas
Pecchini, Maddalena
Colecchia, Antonio
Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease
title Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease
title_full Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease
title_fullStr Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease
title_full_unstemmed Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease
title_short Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease
title_sort role of vitamin d in liver disease and complications of advanced chronic liver disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409132/
https://www.ncbi.nlm.nih.gov/pubmed/36012285
http://dx.doi.org/10.3390/ijms23169016
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