Cargando…
Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis
Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is no cure, and the pharmacological treatment in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409153/ https://www.ncbi.nlm.nih.gov/pubmed/36012393 http://dx.doi.org/10.3390/ijms23169127 |
_version_ | 1784774780890644480 |
---|---|
author | Silva, Inês Mendes, Priscila Guerra, Sofia Pinto, Rui Mateus, Vanessa |
author_facet | Silva, Inês Mendes, Priscila Guerra, Sofia Pinto, Rui Mateus, Vanessa |
author_sort | Silva, Inês |
collection | PubMed |
description | Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is no cure, and the pharmacological treatment includes drugs that induce and keep the patient in remission, not reversing the underlying pathogenic mechanism. These therapies, in the long term, may cause various side effects and complications, which has increased the need to investigate new, more effective, and safer pharmacological approaches. In preclinical studies, topiramate has demonstrated a potential anti-inflammatory effect by inhibiting the production of several pro-inflammatory cytokines. This study aimed to investigate the effect of topiramate in a chronic TNBS-induced colitis model in rodents. Experimental colitis was induced by four intrarectal administrations of 1% TNBS in female CD-1 mice. Topiramate 10 and 20 mg were administered intraperitoneally for 14 days. Several parameters were evaluated, such as bodyweight, alkaline phosphatase (ALP), fecal hemoglobin, fecal calprotectin, tumor necrosis factor (TNF)-α, and interleukin (IL)-10. Topiramate reduces TNBS-induced colonic damage in a model of chronic experimental colitis and normalizes the stool consistency and anus appearance. Additionally, topiramate significantly reduced the concentration of ALP, fecal hemoglobin, fecal calprotectin, TNF-α, and IL-10, demonstrating it to be a promising pharmacological approach for the treatment of IBD in the future. |
format | Online Article Text |
id | pubmed-9409153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94091532022-08-26 Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis Silva, Inês Mendes, Priscila Guerra, Sofia Pinto, Rui Mateus, Vanessa Int J Mol Sci Article Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is no cure, and the pharmacological treatment includes drugs that induce and keep the patient in remission, not reversing the underlying pathogenic mechanism. These therapies, in the long term, may cause various side effects and complications, which has increased the need to investigate new, more effective, and safer pharmacological approaches. In preclinical studies, topiramate has demonstrated a potential anti-inflammatory effect by inhibiting the production of several pro-inflammatory cytokines. This study aimed to investigate the effect of topiramate in a chronic TNBS-induced colitis model in rodents. Experimental colitis was induced by four intrarectal administrations of 1% TNBS in female CD-1 mice. Topiramate 10 and 20 mg were administered intraperitoneally for 14 days. Several parameters were evaluated, such as bodyweight, alkaline phosphatase (ALP), fecal hemoglobin, fecal calprotectin, tumor necrosis factor (TNF)-α, and interleukin (IL)-10. Topiramate reduces TNBS-induced colonic damage in a model of chronic experimental colitis and normalizes the stool consistency and anus appearance. Additionally, topiramate significantly reduced the concentration of ALP, fecal hemoglobin, fecal calprotectin, TNF-α, and IL-10, demonstrating it to be a promising pharmacological approach for the treatment of IBD in the future. MDPI 2022-08-15 /pmc/articles/PMC9409153/ /pubmed/36012393 http://dx.doi.org/10.3390/ijms23169127 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Silva, Inês Mendes, Priscila Guerra, Sofia Pinto, Rui Mateus, Vanessa Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis |
title | Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis |
title_full | Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis |
title_fullStr | Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis |
title_full_unstemmed | Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis |
title_short | Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis |
title_sort | anti-inflammatory effect of topiramate in a chronic model of tnbs-induced colitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409153/ https://www.ncbi.nlm.nih.gov/pubmed/36012393 http://dx.doi.org/10.3390/ijms23169127 |
work_keys_str_mv | AT silvaines antiinflammatoryeffectoftopiramateinachronicmodeloftnbsinducedcolitis AT mendespriscila antiinflammatoryeffectoftopiramateinachronicmodeloftnbsinducedcolitis AT guerrasofia antiinflammatoryeffectoftopiramateinachronicmodeloftnbsinducedcolitis AT pintorui antiinflammatoryeffectoftopiramateinachronicmodeloftnbsinducedcolitis AT mateusvanessa antiinflammatoryeffectoftopiramateinachronicmodeloftnbsinducedcolitis |