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Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier
Blood-brain barrier (BBB) integrity is essential to maintaining brain health. Aging-related alterations could lead to chronic progressive leakiness of the BBB, which is directly correlated with cerebrovascular diseases. Indeed, the BBB breakdown during acute ischemic stroke is critical. It remains u...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409167/ https://www.ncbi.nlm.nih.gov/pubmed/36012745 http://dx.doi.org/10.3390/ijms23169486 |
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author | Alonso-Alonso, Maria Luz Sampedro-Viana, Ana Fernández-Rodicio, Sabela Bazarra-Barreiros, Marcos Ouro, Alberto Sobrino, Tomás Campos, Francisco Castillo, José Hervella, Pablo Iglesias-Rey, Ramón |
author_facet | Alonso-Alonso, Maria Luz Sampedro-Viana, Ana Fernández-Rodicio, Sabela Bazarra-Barreiros, Marcos Ouro, Alberto Sobrino, Tomás Campos, Francisco Castillo, José Hervella, Pablo Iglesias-Rey, Ramón |
author_sort | Alonso-Alonso, Maria Luz |
collection | PubMed |
description | Blood-brain barrier (BBB) integrity is essential to maintaining brain health. Aging-related alterations could lead to chronic progressive leakiness of the BBB, which is directly correlated with cerebrovascular diseases. Indeed, the BBB breakdown during acute ischemic stroke is critical. It remains unclear, however, whether BBB dysfunction is one of the first events that leads to brain disease or a down-stream consequence. This review will focus on the BBB dysfunction associated with cerebrovascular disease. An added difficulty is its association with the deleterious or reparative effect, which depends on the stroke phase. We will first outline the BBB structure and function. Then, we will focus on the spatiotemporal chronic, slow, and progressive BBB alteration related to ischemic stroke. Finally, we will propose a new perspective on preventive therapeutic strategies associated with brain aging based on targeting specific components of the BBB. Understanding BBB age-evolutions will be beneficial for new drug development and the identification of the best performance window times. This could have a direct impact on clinical translation and personalised medicine. |
format | Online Article Text |
id | pubmed-9409167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94091672022-08-26 Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier Alonso-Alonso, Maria Luz Sampedro-Viana, Ana Fernández-Rodicio, Sabela Bazarra-Barreiros, Marcos Ouro, Alberto Sobrino, Tomás Campos, Francisco Castillo, José Hervella, Pablo Iglesias-Rey, Ramón Int J Mol Sci Review Blood-brain barrier (BBB) integrity is essential to maintaining brain health. Aging-related alterations could lead to chronic progressive leakiness of the BBB, which is directly correlated with cerebrovascular diseases. Indeed, the BBB breakdown during acute ischemic stroke is critical. It remains unclear, however, whether BBB dysfunction is one of the first events that leads to brain disease or a down-stream consequence. This review will focus on the BBB dysfunction associated with cerebrovascular disease. An added difficulty is its association with the deleterious or reparative effect, which depends on the stroke phase. We will first outline the BBB structure and function. Then, we will focus on the spatiotemporal chronic, slow, and progressive BBB alteration related to ischemic stroke. Finally, we will propose a new perspective on preventive therapeutic strategies associated with brain aging based on targeting specific components of the BBB. Understanding BBB age-evolutions will be beneficial for new drug development and the identification of the best performance window times. This could have a direct impact on clinical translation and personalised medicine. MDPI 2022-08-22 /pmc/articles/PMC9409167/ /pubmed/36012745 http://dx.doi.org/10.3390/ijms23169486 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alonso-Alonso, Maria Luz Sampedro-Viana, Ana Fernández-Rodicio, Sabela Bazarra-Barreiros, Marcos Ouro, Alberto Sobrino, Tomás Campos, Francisco Castillo, José Hervella, Pablo Iglesias-Rey, Ramón Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier |
title | Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier |
title_full | Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier |
title_fullStr | Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier |
title_full_unstemmed | Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier |
title_short | Need for a Paradigm Shift in the Treatment of Ischemic Stroke: The Blood-Brain Barrier |
title_sort | need for a paradigm shift in the treatment of ischemic stroke: the blood-brain barrier |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409167/ https://www.ncbi.nlm.nih.gov/pubmed/36012745 http://dx.doi.org/10.3390/ijms23169486 |
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