4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons. Mutations in the superoxide dismutase (SOD1) gene, causing protein misfolding and aggregation, were suggested as the pathogenic mechanisms involved in familial ALS cases. In t...

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Detalles Bibliográficos
Autores principales: Alfahel, Leenor, Argueti-Ostrovsky, Shirel, Barel, Shir, Ali Saleh, Mahmood, Kahn, Joy, Azoulay-Ginsburg, Salome, Rothstein, Ayelet, Ebbinghaus, Simon, Gruzman, Arie, Israelson, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409193/
https://www.ncbi.nlm.nih.gov/pubmed/36012668
http://dx.doi.org/10.3390/ijms23169403

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