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The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus

The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimula...

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Autores principales: Clauss, Nikki, Allen, Kelsey Brass, Billings, Katie D., Tolliver, Mikayla D. M., Garza, Ray, Byrd-Craven, Jennifer, Campbell, Polly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409213/
https://www.ncbi.nlm.nih.gov/pubmed/36012509
http://dx.doi.org/10.3390/ijms23169245
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author Clauss, Nikki
Allen, Kelsey Brass
Billings, Katie D.
Tolliver, Mikayla D. M.
Garza, Ray
Byrd-Craven, Jennifer
Campbell, Polly
author_facet Clauss, Nikki
Allen, Kelsey Brass
Billings, Katie D.
Tolliver, Mikayla D. M.
Garza, Ray
Byrd-Craven, Jennifer
Campbell, Polly
author_sort Clauss, Nikki
collection PubMed
description The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimulates the same neuroendocrine systems influenced by early stress, using a mouse model. Behavioral and genetic approaches were used to assess how a Western-pattern diet (WPD) interacts with PS and sex to impact the expression of anxiety-like behavior in an open-field arena, as well as the expression of the glucocorticoid receptor in the hippocampus, D1 dopamine receptors in the nucleus accumbens, and D2 dopamine receptors in the ventral tegmental area. Overall, the results demonstrated that a prenatal WPD mitigates the effects of maternal stress in dams and offspring. These results help to elucidate the relationship between pre- and post-natal nutrition, gene expression, and behaviors that lead to long-term health effects.
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spelling pubmed-94092132022-08-26 The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus Clauss, Nikki Allen, Kelsey Brass Billings, Katie D. Tolliver, Mikayla D. M. Garza, Ray Byrd-Craven, Jennifer Campbell, Polly Int J Mol Sci Article The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimulates the same neuroendocrine systems influenced by early stress, using a mouse model. Behavioral and genetic approaches were used to assess how a Western-pattern diet (WPD) interacts with PS and sex to impact the expression of anxiety-like behavior in an open-field arena, as well as the expression of the glucocorticoid receptor in the hippocampus, D1 dopamine receptors in the nucleus accumbens, and D2 dopamine receptors in the ventral tegmental area. Overall, the results demonstrated that a prenatal WPD mitigates the effects of maternal stress in dams and offspring. These results help to elucidate the relationship between pre- and post-natal nutrition, gene expression, and behaviors that lead to long-term health effects. MDPI 2022-08-17 /pmc/articles/PMC9409213/ /pubmed/36012509 http://dx.doi.org/10.3390/ijms23169245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Clauss, Nikki
Allen, Kelsey Brass
Billings, Katie D.
Tolliver, Mikayla D. M.
Garza, Ray
Byrd-Craven, Jennifer
Campbell, Polly
The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
title The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
title_full The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
title_fullStr The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
title_full_unstemmed The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
title_short The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
title_sort modification of offspring stress-related behavior and the expression of drd1, drd2, and nr3c1 by a western-pattern diet in mus musculus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409213/
https://www.ncbi.nlm.nih.gov/pubmed/36012509
http://dx.doi.org/10.3390/ijms23169245
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