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The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus
The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimula...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409213/ https://www.ncbi.nlm.nih.gov/pubmed/36012509 http://dx.doi.org/10.3390/ijms23169245 |
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author | Clauss, Nikki Allen, Kelsey Brass Billings, Katie D. Tolliver, Mikayla D. M. Garza, Ray Byrd-Craven, Jennifer Campbell, Polly |
author_facet | Clauss, Nikki Allen, Kelsey Brass Billings, Katie D. Tolliver, Mikayla D. M. Garza, Ray Byrd-Craven, Jennifer Campbell, Polly |
author_sort | Clauss, Nikki |
collection | PubMed |
description | The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimulates the same neuroendocrine systems influenced by early stress, using a mouse model. Behavioral and genetic approaches were used to assess how a Western-pattern diet (WPD) interacts with PS and sex to impact the expression of anxiety-like behavior in an open-field arena, as well as the expression of the glucocorticoid receptor in the hippocampus, D1 dopamine receptors in the nucleus accumbens, and D2 dopamine receptors in the ventral tegmental area. Overall, the results demonstrated that a prenatal WPD mitigates the effects of maternal stress in dams and offspring. These results help to elucidate the relationship between pre- and post-natal nutrition, gene expression, and behaviors that lead to long-term health effects. |
format | Online Article Text |
id | pubmed-9409213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94092132022-08-26 The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus Clauss, Nikki Allen, Kelsey Brass Billings, Katie D. Tolliver, Mikayla D. M. Garza, Ray Byrd-Craven, Jennifer Campbell, Polly Int J Mol Sci Article The impact of early developmental experience on neurobiological pathways that may contribute to the association between diet and behavior have not yet been elucidated. The focus of the current study was to determine whether the impact of prenatal stress (PS) could be mitigated by a diet that stimulates the same neuroendocrine systems influenced by early stress, using a mouse model. Behavioral and genetic approaches were used to assess how a Western-pattern diet (WPD) interacts with PS and sex to impact the expression of anxiety-like behavior in an open-field arena, as well as the expression of the glucocorticoid receptor in the hippocampus, D1 dopamine receptors in the nucleus accumbens, and D2 dopamine receptors in the ventral tegmental area. Overall, the results demonstrated that a prenatal WPD mitigates the effects of maternal stress in dams and offspring. These results help to elucidate the relationship between pre- and post-natal nutrition, gene expression, and behaviors that lead to long-term health effects. MDPI 2022-08-17 /pmc/articles/PMC9409213/ /pubmed/36012509 http://dx.doi.org/10.3390/ijms23169245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Clauss, Nikki Allen, Kelsey Brass Billings, Katie D. Tolliver, Mikayla D. M. Garza, Ray Byrd-Craven, Jennifer Campbell, Polly The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus |
title | The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus |
title_full | The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus |
title_fullStr | The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus |
title_full_unstemmed | The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus |
title_short | The Modification of Offspring Stress-Related Behavior and the Expression of Drd1, Drd2, and Nr3c1 by a Western-Pattern Diet in Mus Musculus |
title_sort | modification of offspring stress-related behavior and the expression of drd1, drd2, and nr3c1 by a western-pattern diet in mus musculus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409213/ https://www.ncbi.nlm.nih.gov/pubmed/36012509 http://dx.doi.org/10.3390/ijms23169245 |
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