Cargando…

Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway

Colon cancer is a common malignant tumor of the digestive tract, and it is considered among the biggest killers. Scientific and reasonable treatments can effectively improve the survival rate of patients if performed in the early stages. Polyphyllin I (PPI), a pennogenyl saponin isolated from Paris...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Qihui, Jia, Lanlan, Huang, Chao, Qi, Qi, Jahangir, Asad, Xia, Yu, Liu, Wentao, Shi, Riyi, Tang, Li, Chen, Zhengli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409257/ https://www.ncbi.nlm.nih.gov/pubmed/36012632 http://dx.doi.org/10.3390/ijms23169368

Ejemplares similares

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
por: Pang, Dejiang, et al.
Publicado: (2019)

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
por: Zhang, Chao, et al.
Publicado: (2016)

Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway
por: Shi, Liangqin, et al.
Publicado: (2020)

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
por: Pang, Dejiang, et al.
Publicado: (2020)

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway
por: Long, Jianwen, et al.
Publicado: (2020)

Correction: Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
por: Pang, Dejiang, et al.
Publicado: (2023)

Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway
por: Shi, Yang, et al.
Publicado: (2016)

Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway
por: Jiao, Yuhan, et al.
Publicado: (2022)

Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells
por: Luo, Qihui, et al.
Publicado: (2018)

Larotrectinib induces autophagic cell death through AMPK/mTOR signalling in colon cancer
por: Kong, Wencheng, et al.
Publicado: (2022)

TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice
por: Jia, Lanlan, et al.
Publicado: (2022)

Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway
por: Liu, Jingjing, et al.
Publicado: (2020)

Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells
por: Li, Jun-Kui, et al.
Publicado: (2022)

Moxidectin induces Cytostatic Autophagic Cell Death of Glioma Cells through inhibiting the AKT/mTOR Signalling Pathway: Erratum
por: Liu, Jingjing, et al.
Publicado: (2023)

Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity
por: Yao, Chong, et al.
Publicado: (2018)

Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells
por: Tsai, Dai-Hua, et al.
Publicado: (2018)

Mouse embryonic palatal mesenchymal cells maintain stemness through the PTEN-Akt-mTOR autophagic pathway
por: Shi, Lungang, et al.
Publicado: (2019)

Huaier Extract Induces Autophagic Cell Death by Inhibiting the mTOR/S6K Pathway in Breast Cancer Cells
por: Wang, Xiaolong, et al.
Publicado: (2015)

Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound
por: Tungsukruthai, Sucharat, et al.
Publicado: (2021)

Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
por: Jeong, Yun Hee, et al.
Publicado: (2022)

TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells
por: Yang, Chen, et al.
Publicado: (2021)

Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis
por: Feng, Feifei, et al.
Publicado: (2019)

Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway
por: Yoshikawa, Nobuhisa, et al.
Publicado: (2020)

Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells
por: Kim, Aeyung, et al.
Publicado: (2013)

G9a Inhibition Induces Autophagic Cell Death via AMPK/mTOR Pathway in Bladder Transitional Cell Carcinoma
por: Li, Feng, et al.
Publicado: (2015)

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling
por: Liu, H-L, et al.
Publicado: (2011)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
por: Yuan, Yong-Liang, et al.
Publicado: (2019)

ROS generation and autophagosome accumulation contribute to the DMAMCL-induced inhibition of glioma cell proliferation by regulating the ROS/MAPK signaling pathway and suppressing the Akt/mTOR signaling pathway
por: Wang, Yanjun, et al.
Publicado: (2019)

CXCR4 blockade sensitizes osteosarcoma to doxorubicin by inducing autophagic cell death via PI3K-Akt-mTOR pathway inhibition
por: Liao, Yu-Xin, et al.
Publicado: (2021)

Norcantharidin alone or in combination with crizotinib induces autophagic cell death in hepatocellular carcinoma by repressing c-Met-mTOR signaling
por: Sun, Chao-Yue, et al.
Publicado: (2017)

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

ROS, Klotho and mTOR in cardiorenal aging
por: Daneshgar, Nastaran, et al.
Publicado: (2020)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway
por: Li, Xing, et al.
Publicado: (2022)

Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Metformin promotes cell proliferation and osteogenesis under high glucose condition by regulating the ROS-AKT-mTOR axis
por: Zhou, Renyi, et al.
Publicado: (2020)

Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway
por: Ni, Zhijing, et al.
Publicado: (2021)

CLEC5A regulates the proliferation and migration of colon cancer via the AKT/mTOR signaling pathway
por: Pan, Yang, et al.
Publicado: (2023)

α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation
por: Sun, Jian, et al.
Publicado: (2019)

Inhibitory effects of petasin on human colon carcinoma cells mediated by inactivation of Akt/mTOR pathway
por: Lyu, Xi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pgul573tcj4lmveo35kcv174hs