Cargando…

Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion

During ischemic stroke, infarct growth before recanalization diminishes functional outcome. Hence, adjunct treatment options to protect the ischemic penumbra before recanalization are eagerly awaited. In experimental stroke targeting two different pathways conferred protection from penumbral tissue...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bieber, Michael, Schuhmann, Michael K., Bellut, Maximilian, Stegner, David, Heinze, Katrin G., Pham, Mirko, Nieswandt, Bernhard, Stoll, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409377/ https://www.ncbi.nlm.nih.gov/pubmed/36012752 http://dx.doi.org/10.3390/ijms23169496

Ejemplares similares

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice
por: Schuhmann, Michael K., et al.
Publicado: (2021)

Sustained Reperfusion after Blockade of Glycoprotein-Receptor-Ib in Focal Cerebral Ischemia: An MRI Study at 17.6 Tesla
por: Pham, Mirko, et al.
Publicado: (2011)

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke
por: Schuhmann, Michael K., et al.
Publicado: (2017)

Targeting Platelet GPVI Plus rt-PA Administration but Not α2β1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice
por: Schuhmann, Michael K., et al.
Publicado: (2019)

Danger-associated molecular patterns are locally released during occlusion in hyper-acute stroke
por: Schuhmann, Michael K., et al.
Publicado: (2021)

Infarct growth precedes cerebral thrombosis following experimental stroke in mice
por: Göb, Vanessa, et al.
Publicado: (2021)

NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke
por: Bellut, Maximilian, et al.
Publicado: (2021)

CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke
por: Schuhmann, Michael K., et al.
Publicado: (2020)

An intravascular perspective on hyper-acute neutrophil, T-cell and platelet responses: Similarities between human and experimental stroke
por: Stoll, Guido, et al.
Publicado: (2022)

Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice
por: Bellut, Maximilian, et al.
Publicado: (2023)

Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function
por: Bieber, Michael, et al.
Publicado: (2019)

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
por: Dütting, Sebastian, et al.
Publicado: (2017)

Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke
por: Kollikowski, Alexander M., et al.
Publicado: (2021)

Vasoactive Soluble Endoglin: A Novel Biomarker Indicative of Reperfusion after Cerebral Large-Vessel Occlusion
por: Haarmann, Axel, et al.
Publicado: (2023)

NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions
por: Bellut, Maximilian, et al.
Publicado: (2022)

Distinct Alterations in Oxygenation, Ion Composition and Acid-Base Balance in Cerebral Collaterals During Large-Vessel Occlusion Stroke
por: Feick, Jörn, et al.
Publicado: (2023)

Validity and Efficacy of Methods to Define Blood Brain Barrier Integrity in Experimental Ischemic Strokes: A Comparison of Albumin Western Blot, IgG Western Blot and Albumin Immunofluorescence
por: Franke, Maximilian, et al.
Publicado: (2021)

Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)
por: Popp, Michael, et al.
Publicado: (2015)

Treatment with Edoxaban Attenuates Acute Stroke Severity in Mice by Reducing Blood–Brain Barrier Damage and Inflammation
por: Bieber, Michael, et al.
Publicado: (2021)

Selective Tropism of Dengue Virus for Human Glycoprotein Ib
por: Attatippaholkun, Nattapol, et al.
Publicado: (2018)

Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β
por: Jardin, Isaac, et al.
Publicado: (2022)

Adhesion Maturation of Neutrophils on Nanoscopically Presented Platelet Glycoprotein Ibα
por: Kruss, Sebastian, et al.
Publicado: (2013)

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury
por: Stegner, David, et al.
Publicado: (2019)

Regulation and Release of Vasoactive Endoglin by Brain Endothelium in Response to Hypoxia/Reoxygenation in Stroke
por: Haarmann, Axel, et al.
Publicado: (2022)

On the association of glycoprotein Ib and actin-binding protein in human platelets
Publicado: (1985)

The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
por: Romo, Gabriel M., et al.
Publicado: (1999)

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses
por: Azimi, Iman, et al.
Publicado: (2019)

Neuroprotective properties of the PrP-like Shadoo glycoprotein assessed in the middle cerebral artery occlusion model of ischemia
por: Daude, Nathalie, et al.
Publicado: (2015)

Platelet glycoprotein Ibα is an important mediator of ischemic stroke in mice
por: De Meyer, Simon F, et al.
Publicado: (2011)

Publisher Correction: Selective Tropism of Dengue Virus for Human Glycoprotein Ib
por: Attatippaholkun, Nattapol, et al.
Publicado: (2018)

Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets
por: Corona de la Peña, Norma, et al.
Publicado: (2017)

New insights into glycoprotein Ibα desialylation-mediated platelet clearance
por: Yule, Jack, et al.
Publicado: (2020)

Defining cerebral leukocyte populations in local ischemic blood samples from patients with hyperacute stroke
por: Zimmermann, Lena, et al.
Publicado: (2022)

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
por: Wang, Yingchun, et al.
Publicado: (2020)

Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
por: Yu, Changhui, et al.
Publicado: (2022)

Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta
por: Dynes, Joseph L., et al.
Publicado: (2020)

NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells
por: Wu, Beibei, et al.
Publicado: (2021)

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
por: Tao, Yue, et al.
Publicado: (2016)

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke
por: Denorme, Frederik, et al.
Publicado: (2019)

Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression
por: Yan, Rong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_feot19ndngkj7euh8eol1cgoo2