Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines

Novel nanocomposite materials based on Fe(3)O(4) magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Do...

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Autores principales: Demin, Alexander M., Vakhrushev, Alexander V., Pershina, Alexandra G., Valova, Marina S., Efimova, Lina V., Syomchina, Alexandra A., Uimin, Mikhail A., Minin, Artem S., Levit, Galina L., Krasnov, Victor P., Charushin, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409415/
https://www.ncbi.nlm.nih.gov/pubmed/36012356
http://dx.doi.org/10.3390/ijms23169093
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author Demin, Alexander M.
Vakhrushev, Alexander V.
Pershina, Alexandra G.
Valova, Marina S.
Efimova, Lina V.
Syomchina, Alexandra A.
Uimin, Mikhail A.
Minin, Artem S.
Levit, Galina L.
Krasnov, Victor P.
Charushin, Valery N.
author_facet Demin, Alexander M.
Vakhrushev, Alexander V.
Pershina, Alexandra G.
Valova, Marina S.
Efimova, Lina V.
Syomchina, Alexandra A.
Uimin, Mikhail A.
Minin, Artem S.
Levit, Galina L.
Krasnov, Victor P.
Charushin, Valery N.
author_sort Demin, Alexander M.
collection PubMed
description Novel nanocomposite materials based on Fe(3)O(4) magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
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spelling pubmed-94094152022-08-26 Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines Demin, Alexander M. Vakhrushev, Alexander V. Pershina, Alexandra G. Valova, Marina S. Efimova, Lina V. Syomchina, Alexandra A. Uimin, Mikhail A. Minin, Artem S. Levit, Galina L. Krasnov, Victor P. Charushin, Valery N. Int J Mol Sci Article Novel nanocomposite materials based on Fe(3)O(4) magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated. MDPI 2022-08-13 /pmc/articles/PMC9409415/ /pubmed/36012356 http://dx.doi.org/10.3390/ijms23169093 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Demin, Alexander M.
Vakhrushev, Alexander V.
Pershina, Alexandra G.
Valova, Marina S.
Efimova, Lina V.
Syomchina, Alexandra A.
Uimin, Mikhail A.
Minin, Artem S.
Levit, Galina L.
Krasnov, Victor P.
Charushin, Valery N.
Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines
title Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines
title_full Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines
title_fullStr Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines
title_full_unstemmed Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines
title_short Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe(3)O(4) Nanoparticles with a SiO(2)/PEG Shell and Study of Their Effects on Cancer Cell Lines
title_sort magnetic-responsive doxorubicin-containing materials based on fe(3)o(4) nanoparticles with a sio(2)/peg shell and study of their effects on cancer cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409415/
https://www.ncbi.nlm.nih.gov/pubmed/36012356
http://dx.doi.org/10.3390/ijms23169093
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