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Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion

Embryos with homozygous mutation of Eftud2 in their neural crest cells (Eftud2(ncc−/−)) have brain and craniofacial malformations, hyperactivation of the P53-pathway and die before birth. Treatment of Eftud2(ncc−/−) embryos with pifithrin-α, a P53-inhibitor, partly improved brain and craniofacial de...

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Detalles Bibliográficos
Autores principales:	Beauchamp, Marie-Claude, Boucher, Alexia, Dong, Yanchen, Aber, Rachel, Jerome-Majewska, Loydie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409426/ https://www.ncbi.nlm.nih.gov/pubmed/36012294 http://dx.doi.org/10.3390/ijms23169033

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