Microglia Impairs Proliferation and Induces Senescence In-Vitro in NGF Releasing Cells Used in Encapsulated Cell Biodelivery for Alzheimer’s Disease Therapy

There is no cure yet available for Alzheimer’s disease (AD). We recently optimized encapsulated cell biodelivery (ECB) devices releasing human mature nerve growth factor (hmNGF), termed ECB-NGF, to the basal forebrain of AD patients. The ECB-NGF delivery resulted in increased CSF cholinergic markers...

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Detalles Bibliográficos
Autores principales: Mitra, Sumonto, Gera, Ruchi, Sundheimer, Julia, Lemee, Marine, Wahlberg, Lars U., Linderoth, Bengt, Eriksdotter, Maria, Behbahani, Homira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409429/
https://www.ncbi.nlm.nih.gov/pubmed/36012296
http://dx.doi.org/10.3390/ijms23169011

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