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Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart

In vertebrates, the coordinated beat of the early heart tube drives cardiogenesis and supports embryonic growth. How the heart pumps at this valveless stage marks a fascinating problem that is of vital significance for understanding cardiac development and defects. The developing heart achieves its...

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Detalles Bibliográficos
Autores principales: Wang, Shang, Larina, Irina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409458/
https://www.ncbi.nlm.nih.gov/pubmed/36005431
http://dx.doi.org/10.3390/jcdd9080267
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author Wang, Shang
Larina, Irina V.
author_facet Wang, Shang
Larina, Irina V.
author_sort Wang, Shang
collection PubMed
description In vertebrates, the coordinated beat of the early heart tube drives cardiogenesis and supports embryonic growth. How the heart pumps at this valveless stage marks a fascinating problem that is of vital significance for understanding cardiac development and defects. The developing heart achieves its function at the same time as continuous and dramatic morphological changes, which in turn modify its pumping dynamics. The beauty of this muti-time-scale process also highlights its complexity that requires interdisciplinary approaches to study. High-resolution optical imaging, particularly fast, four-dimensional (4D) imaging, plays a critical role in revealing the process of pumping, instructing numerical modeling, and enabling biomechanical analyses. In this review, we aim to connect the investigation of valveless pumping mechanisms with the recent advancements in embryonic cardiodynamic imaging, facilitating interactions between these two areas of study, in hopes of encouraging and motivating innovative work to further understand the early heartbeat.
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spelling pubmed-94094582022-08-26 Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart Wang, Shang Larina, Irina V. J Cardiovasc Dev Dis Review In vertebrates, the coordinated beat of the early heart tube drives cardiogenesis and supports embryonic growth. How the heart pumps at this valveless stage marks a fascinating problem that is of vital significance for understanding cardiac development and defects. The developing heart achieves its function at the same time as continuous and dramatic morphological changes, which in turn modify its pumping dynamics. The beauty of this muti-time-scale process also highlights its complexity that requires interdisciplinary approaches to study. High-resolution optical imaging, particularly fast, four-dimensional (4D) imaging, plays a critical role in revealing the process of pumping, instructing numerical modeling, and enabling biomechanical analyses. In this review, we aim to connect the investigation of valveless pumping mechanisms with the recent advancements in embryonic cardiodynamic imaging, facilitating interactions between these two areas of study, in hopes of encouraging and motivating innovative work to further understand the early heartbeat. MDPI 2022-08-15 /pmc/articles/PMC9409458/ /pubmed/36005431 http://dx.doi.org/10.3390/jcdd9080267 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Shang
Larina, Irina V.
Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart
title Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart
title_full Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart
title_fullStr Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart
title_full_unstemmed Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart
title_short Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart
title_sort following the beat: imaging the valveless pumping function in the early embryonic heart
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409458/
https://www.ncbi.nlm.nih.gov/pubmed/36005431
http://dx.doi.org/10.3390/jcdd9080267
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