Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles

Cystic fibrosis transmembrane regulator (CFTR) is a dynamic membrane protein belonging to the ABC transporter family. It is unusual within this family as it is an ion channel, as opposed to a transporter. Activation of CFTR requires ATP and phosphorylation by PKA, and dysregulation of CFTR mediated...

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Detalles Bibliográficos
Autores principales: Aleksandrov, Luba A., Aleksandrov, Adrei A., Jensen, Timothy J., Strauss, Joshua D., Fay, Jonathan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409475/
https://www.ncbi.nlm.nih.gov/pubmed/36012518
http://dx.doi.org/10.3390/ijms23169248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409475/
https://www.ncbi.nlm.nih.gov/pubmed/36012518
http://dx.doi.org/10.3390/ijms23169248

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