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Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study

Menopause, which may accelerate the hallmarks of the natural aging process, represents a point in time characterized by the permanent cessation of menstruation following the loss of ovarian estrogen production. Unlike natural menopause, which is characterized by a gradual decrease in estrogen produc...

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Autores principales: Siriprapanonkul, Pattarawadee, Orprayoon, Nalina, Tuntiviriyapun, Punkavee, Phutrakool, Phanupong, Jaisamrarn, Unnop, Mutirangura, Apiwat, Chaikittisilpa, Sukanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409535/
https://www.ncbi.nlm.nih.gov/pubmed/36006936
http://dx.doi.org/10.1371/journal.pone.0273403
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author Siriprapanonkul, Pattarawadee
Orprayoon, Nalina
Tuntiviriyapun, Punkavee
Phutrakool, Phanupong
Jaisamrarn, Unnop
Mutirangura, Apiwat
Chaikittisilpa, Sukanya
author_facet Siriprapanonkul, Pattarawadee
Orprayoon, Nalina
Tuntiviriyapun, Punkavee
Phutrakool, Phanupong
Jaisamrarn, Unnop
Mutirangura, Apiwat
Chaikittisilpa, Sukanya
author_sort Siriprapanonkul, Pattarawadee
collection PubMed
description Menopause, which may accelerate the hallmarks of the natural aging process, represents a point in time characterized by the permanent cessation of menstruation following the loss of ovarian estrogen production. Unlike natural menopause, which is characterized by a gradual decrease in estrogen production, when both ovaries are removed before the natural age of menopause, the onset of estrogen deprivation is abrupt. Further, a decrease in genome methylation frequently occurs in aging cells, and the major interspersed repetitive DNA elements in humans are Alu elements. In blood cells, Alu demethylation starts at an age of approximately 40 years, and increases with age. Here, we explored the Alu methylation levels corresponding to age-matched pre-menopausal, naturally postmenopausal, and surgically postmenopausal women aged 45–55 years (n = 60 in each group). Our results indicated that the body mass index (BMI), time-since-menopause, and Alu methylation levels corresponding to the three groups were significantly different. However, no correlations between Alu methylation level and BMI, time-since-menopause, or age were observed. Additionally, the Alu methylation level corresponding to the natural post-menopause group was significantly lower those corresponding to the pre-menopausal (p = 0.001) and surgical post-menopausal (p = 0.037) groups. In conclusion, Alu hypomethylation occurs in naturally postmenopausal women, implying that when women reach the age of natural menopause, the cell aging process may progress significantly with genome hypomethylation. These findings, notwithstanding, further studies are necessary to clarify whether bilateral oophorectomy before the age of menopause affects the cell aging process to a greater extent than natural menopause, and whether estrogen therapy or other interventions can delay cell aging in this regard.
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spelling pubmed-94095352022-08-26 Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study Siriprapanonkul, Pattarawadee Orprayoon, Nalina Tuntiviriyapun, Punkavee Phutrakool, Phanupong Jaisamrarn, Unnop Mutirangura, Apiwat Chaikittisilpa, Sukanya PLoS One Research Article Menopause, which may accelerate the hallmarks of the natural aging process, represents a point in time characterized by the permanent cessation of menstruation following the loss of ovarian estrogen production. Unlike natural menopause, which is characterized by a gradual decrease in estrogen production, when both ovaries are removed before the natural age of menopause, the onset of estrogen deprivation is abrupt. Further, a decrease in genome methylation frequently occurs in aging cells, and the major interspersed repetitive DNA elements in humans are Alu elements. In blood cells, Alu demethylation starts at an age of approximately 40 years, and increases with age. Here, we explored the Alu methylation levels corresponding to age-matched pre-menopausal, naturally postmenopausal, and surgically postmenopausal women aged 45–55 years (n = 60 in each group). Our results indicated that the body mass index (BMI), time-since-menopause, and Alu methylation levels corresponding to the three groups were significantly different. However, no correlations between Alu methylation level and BMI, time-since-menopause, or age were observed. Additionally, the Alu methylation level corresponding to the natural post-menopause group was significantly lower those corresponding to the pre-menopausal (p = 0.001) and surgical post-menopausal (p = 0.037) groups. In conclusion, Alu hypomethylation occurs in naturally postmenopausal women, implying that when women reach the age of natural menopause, the cell aging process may progress significantly with genome hypomethylation. These findings, notwithstanding, further studies are necessary to clarify whether bilateral oophorectomy before the age of menopause affects the cell aging process to a greater extent than natural menopause, and whether estrogen therapy or other interventions can delay cell aging in this regard. Public Library of Science 2022-08-25 /pmc/articles/PMC9409535/ /pubmed/36006936 http://dx.doi.org/10.1371/journal.pone.0273403 Text en © 2022 Siriprapanonkul et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Siriprapanonkul, Pattarawadee
Orprayoon, Nalina
Tuntiviriyapun, Punkavee
Phutrakool, Phanupong
Jaisamrarn, Unnop
Mutirangura, Apiwat
Chaikittisilpa, Sukanya
Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
title Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
title_full Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
title_fullStr Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
title_full_unstemmed Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
title_short Alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
title_sort alu hypomethylation in naturally and surgically postmenopausal women; a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409535/
https://www.ncbi.nlm.nih.gov/pubmed/36006936
http://dx.doi.org/10.1371/journal.pone.0273403
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