Cargando…
High activity of an affinity-matured ACE2 decoy against Omicron SARS-CoV-2 and pre-emergent coronaviruses
The viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly its cell-binding spike protein gene, has undergone rapid evolution during the coronavirus disease 2019 (COVID-19) pandemic. Variants including Omicron BA.1 and Omicron BA.2 now seriously threaten the effic...
Autores principales: | Sims, Joshua J., Lian, Sharon, Meggersee, Rosemary L., Kasimsetty, Aradhana, Wilson, James M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409550/ https://www.ncbi.nlm.nih.gov/pubmed/36006993 http://dx.doi.org/10.1371/journal.pone.0271359 |
Ejemplares similares
-
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
por: Zhang, Lianghui, et al.
Publicado: (2022) -
An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants
por: Tanaka, Shiho, et al.
Publicado: (2021) -
Computationally engineered ACE2 decoy binds with nanomolar affinity with the SARS-CoV-2 spike protein
por: Islam, Mohammad S., et al.
Publicado: (2022) -
Machine learning guided design of high affinity ACE2 decoys for SARS-CoV-2 neutralization
por: Chan, Matthew C., et al.
Publicado: (2021) -
An ACE2-Based Decoy Inhibitor Effectively Neutralizes SARS-CoV-2 Omicron BA.5 Variant
por: Zhang, Haoran, et al.
Publicado: (2022)