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Drug-Associated Parosmia: New Perspectives from the WHO Safety Database
Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs associated with parosmia. VigiBase(®) (the WHO pharmacovigil...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409668/ https://www.ncbi.nlm.nih.gov/pubmed/36012880 http://dx.doi.org/10.3390/jcm11164641 |
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author | Merino, Diane Gérard, Alexandre Olivier Thümmler, Susanne Ben Othman, Nouha Viard, Delphine Rocher, Fanny Destere, Alexandre Van Obberghen, Elise Katheryne Drici, Milou-Daniel |
author_facet | Merino, Diane Gérard, Alexandre Olivier Thümmler, Susanne Ben Othman, Nouha Viard, Delphine Rocher, Fanny Destere, Alexandre Van Obberghen, Elise Katheryne Drici, Milou-Daniel |
author_sort | Merino, Diane |
collection | PubMed |
description | Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs associated with parosmia. VigiBase(®) (the WHO pharmacovigilance database) was queried for all reports of “Parosmia” (MedDRA Preferred Term), registered up to 23 January 2022. Disproportionality analysis relied on the reporting odds ratio and the information component. A signal is detected when the lower end of the 95% confidence interval of the information component is positive. We found 14,032 reports of parosmia, with a median patient age of 53 years. Most reported drugs were antiinfectives, among which COVID-19 vaccines accounted for 27.1% of reports. Antibiotics and corticosteroids were involved in 6.8% and 4.6% of reports. Significant disproportionate reporting was detected for corticosteroids, antibiotics, drugs used in nicotine dependence, COVID-19 and HPV vaccines, serotonin–norepinephrine reuptake inhibitors (SNRI), and incretin mimetics. We suggest potential safety signals involving nicotine replacement therapies and vaccines. We also highlight the potential role of less suspected classes, such as SNRIs and incretin mimetics. An iatrogenic etiology should be evoked when parosmia occurs, especially in the elderly. |
format | Online Article Text |
id | pubmed-9409668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94096682022-08-26 Drug-Associated Parosmia: New Perspectives from the WHO Safety Database Merino, Diane Gérard, Alexandre Olivier Thümmler, Susanne Ben Othman, Nouha Viard, Delphine Rocher, Fanny Destere, Alexandre Van Obberghen, Elise Katheryne Drici, Milou-Daniel J Clin Med Article Parosmia is a qualitative distortion of smell perception. Resulting from central causes, sinonasal diseases, and infections, parosmia has also been associated with medications. Therefore, we aimed to investigate potential signals for drugs associated with parosmia. VigiBase(®) (the WHO pharmacovigilance database) was queried for all reports of “Parosmia” (MedDRA Preferred Term), registered up to 23 January 2022. Disproportionality analysis relied on the reporting odds ratio and the information component. A signal is detected when the lower end of the 95% confidence interval of the information component is positive. We found 14,032 reports of parosmia, with a median patient age of 53 years. Most reported drugs were antiinfectives, among which COVID-19 vaccines accounted for 27.1% of reports. Antibiotics and corticosteroids were involved in 6.8% and 4.6% of reports. Significant disproportionate reporting was detected for corticosteroids, antibiotics, drugs used in nicotine dependence, COVID-19 and HPV vaccines, serotonin–norepinephrine reuptake inhibitors (SNRI), and incretin mimetics. We suggest potential safety signals involving nicotine replacement therapies and vaccines. We also highlight the potential role of less suspected classes, such as SNRIs and incretin mimetics. An iatrogenic etiology should be evoked when parosmia occurs, especially in the elderly. MDPI 2022-08-09 /pmc/articles/PMC9409668/ /pubmed/36012880 http://dx.doi.org/10.3390/jcm11164641 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Merino, Diane Gérard, Alexandre Olivier Thümmler, Susanne Ben Othman, Nouha Viard, Delphine Rocher, Fanny Destere, Alexandre Van Obberghen, Elise Katheryne Drici, Milou-Daniel Drug-Associated Parosmia: New Perspectives from the WHO Safety Database |
title | Drug-Associated Parosmia: New Perspectives from the WHO Safety Database |
title_full | Drug-Associated Parosmia: New Perspectives from the WHO Safety Database |
title_fullStr | Drug-Associated Parosmia: New Perspectives from the WHO Safety Database |
title_full_unstemmed | Drug-Associated Parosmia: New Perspectives from the WHO Safety Database |
title_short | Drug-Associated Parosmia: New Perspectives from the WHO Safety Database |
title_sort | drug-associated parosmia: new perspectives from the who safety database |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409668/ https://www.ncbi.nlm.nih.gov/pubmed/36012880 http://dx.doi.org/10.3390/jcm11164641 |
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