Cargando…

History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy

Image-guided radiotherapy (IGRT) enables optimal tumor targeting and sparing of organs-at-risk, which ultimately results in improved outcomes for patients. Magnetic resonance imaging (MRI) revolutionized diagnostic imaging with its superior soft tissue contrast, high spatiotemporal resolution, and f...

Descripción completa

Detalles Bibliográficos
Autores principales: Rammohan, Nikhil, Randall, James W., Yadav, Poonam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409689/
https://www.ncbi.nlm.nih.gov/pubmed/36012969
http://dx.doi.org/10.3390/jcm11164730
_version_ 1784774912730202112
author Rammohan, Nikhil
Randall, James W.
Yadav, Poonam
author_facet Rammohan, Nikhil
Randall, James W.
Yadav, Poonam
author_sort Rammohan, Nikhil
collection PubMed
description Image-guided radiotherapy (IGRT) enables optimal tumor targeting and sparing of organs-at-risk, which ultimately results in improved outcomes for patients. Magnetic resonance imaging (MRI) revolutionized diagnostic imaging with its superior soft tissue contrast, high spatiotemporal resolution, and freedom from ionizing radiation exposure. Over the past few years there has been burgeoning interest in MR-guided radiotherapy (MRgRT) to overcome current challenges in X-ray-based IGRT, including but not limited to, suboptimal soft tissue contrast, lack of efficient daily adaptation, and incremental exposure to ionizing radiation. In this review, we present an overview of the technologic advancements in IGRT that led to MRI-linear accelerator (MRL) integration. Our report is organized in three parts: (1) a historical timeline tracing the origins of radiotherapy and evolution of IGRT, (2) currently available MRL technology, and (3) future directions and aspirations for MRL applications.
format Online
Article
Text
id pubmed-9409689
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94096892022-08-26 History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy Rammohan, Nikhil Randall, James W. Yadav, Poonam J Clin Med Review Image-guided radiotherapy (IGRT) enables optimal tumor targeting and sparing of organs-at-risk, which ultimately results in improved outcomes for patients. Magnetic resonance imaging (MRI) revolutionized diagnostic imaging with its superior soft tissue contrast, high spatiotemporal resolution, and freedom from ionizing radiation exposure. Over the past few years there has been burgeoning interest in MR-guided radiotherapy (MRgRT) to overcome current challenges in X-ray-based IGRT, including but not limited to, suboptimal soft tissue contrast, lack of efficient daily adaptation, and incremental exposure to ionizing radiation. In this review, we present an overview of the technologic advancements in IGRT that led to MRI-linear accelerator (MRL) integration. Our report is organized in three parts: (1) a historical timeline tracing the origins of radiotherapy and evolution of IGRT, (2) currently available MRL technology, and (3) future directions and aspirations for MRL applications. MDPI 2022-08-12 /pmc/articles/PMC9409689/ /pubmed/36012969 http://dx.doi.org/10.3390/jcm11164730 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rammohan, Nikhil
Randall, James W.
Yadav, Poonam
History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy
title History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy
title_full History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy
title_fullStr History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy
title_full_unstemmed History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy
title_short History of Technological Advancements towards MR-Linac: The Future of Image-Guided Radiotherapy
title_sort history of technological advancements towards mr-linac: the future of image-guided radiotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409689/
https://www.ncbi.nlm.nih.gov/pubmed/36012969
http://dx.doi.org/10.3390/jcm11164730
work_keys_str_mv AT rammohannikhil historyoftechnologicaladvancementstowardsmrlinacthefutureofimageguidedradiotherapy
AT randalljamesw historyoftechnologicaladvancementstowardsmrlinacthefutureofimageguidedradiotherapy
AT yadavpoonam historyoftechnologicaladvancementstowardsmrlinacthefutureofimageguidedradiotherapy