Cargando…
Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
During the first outbreak of COVID-19 in Italy, based on the only few cases reported from a Chinese centre at the time, we performed lung transplantation in two patients with irreversible acute respiratory distress syndrome (ARDS) after COVID-19 at our centre. After two years, we report the outcomes...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409702/ https://www.ncbi.nlm.nih.gov/pubmed/36012993 http://dx.doi.org/10.3390/jcm11164754 |
_version_ | 1784774915919970304 |
---|---|
author | Palleschi, Alessandro Crotti, Stefania Scandroglio, Anna Mara Lissoni, Alfredo Fominskiy, Evgeny Rosso, Lorenzo Tosi, Davide Musso, Valeria Blasi, Francesco Gori, Andrea Nosotti, Mario |
author_facet | Palleschi, Alessandro Crotti, Stefania Scandroglio, Anna Mara Lissoni, Alfredo Fominskiy, Evgeny Rosso, Lorenzo Tosi, Davide Musso, Valeria Blasi, Francesco Gori, Andrea Nosotti, Mario |
author_sort | Palleschi, Alessandro |
collection | PubMed |
description | During the first outbreak of COVID-19 in Italy, based on the only few cases reported from a Chinese centre at the time, we performed lung transplantation in two patients with irreversible acute respiratory distress syndrome (ARDS) after COVID-19 at our centre. After two years, we report the outcomes of these cases and some considerations. The first patient, an 18-year-old male, is in excellent conditions twenty-four months after surgery. The second patient was a 48-year-old man; his airways were colonized by carbapenemase-producing klebsiella pneumoniae at the time of lung transplantation, and he had previously suffered from delirium and hallucinations in the intensive care unit. His postoperative clinical course was complicated by dysexecutive behaviour and then septic shock; he died 62 days after surgery. The recently reported experience of different transplantation centres has led to the inclusion of irreversible acute respiratory distress syndrome (ARDS) after COVID-19 among the indications for lung transplantation in carefully selected patients. Our results confirm the feasibility and the good long-term outcomes of lung transplantation for COVID-19-associated ARDS. Nonetheless, our experience corroborates the need for careful recipient selection: special attention must be paid to the single-organ dysfunction principle, the evaluation of any neuro-psychiatric disorder, and MDR germs colonization, before listing. |
format | Online Article Text |
id | pubmed-9409702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94097022022-08-26 Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues Palleschi, Alessandro Crotti, Stefania Scandroglio, Anna Mara Lissoni, Alfredo Fominskiy, Evgeny Rosso, Lorenzo Tosi, Davide Musso, Valeria Blasi, Francesco Gori, Andrea Nosotti, Mario J Clin Med Case Report During the first outbreak of COVID-19 in Italy, based on the only few cases reported from a Chinese centre at the time, we performed lung transplantation in two patients with irreversible acute respiratory distress syndrome (ARDS) after COVID-19 at our centre. After two years, we report the outcomes of these cases and some considerations. The first patient, an 18-year-old male, is in excellent conditions twenty-four months after surgery. The second patient was a 48-year-old man; his airways were colonized by carbapenemase-producing klebsiella pneumoniae at the time of lung transplantation, and he had previously suffered from delirium and hallucinations in the intensive care unit. His postoperative clinical course was complicated by dysexecutive behaviour and then septic shock; he died 62 days after surgery. The recently reported experience of different transplantation centres has led to the inclusion of irreversible acute respiratory distress syndrome (ARDS) after COVID-19 among the indications for lung transplantation in carefully selected patients. Our results confirm the feasibility and the good long-term outcomes of lung transplantation for COVID-19-associated ARDS. Nonetheless, our experience corroborates the need for careful recipient selection: special attention must be paid to the single-organ dysfunction principle, the evaluation of any neuro-psychiatric disorder, and MDR germs colonization, before listing. MDPI 2022-08-15 /pmc/articles/PMC9409702/ /pubmed/36012993 http://dx.doi.org/10.3390/jcm11164754 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Palleschi, Alessandro Crotti, Stefania Scandroglio, Anna Mara Lissoni, Alfredo Fominskiy, Evgeny Rosso, Lorenzo Tosi, Davide Musso, Valeria Blasi, Francesco Gori, Andrea Nosotti, Mario Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues |
title | Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues |
title_full | Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues |
title_fullStr | Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues |
title_full_unstemmed | Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues |
title_short | Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues |
title_sort | lung transplant for ards after covid-19: long-term outcomes and considerations about detrimental issues |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409702/ https://www.ncbi.nlm.nih.gov/pubmed/36012993 http://dx.doi.org/10.3390/jcm11164754 |
work_keys_str_mv | AT palleschialessandro lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT crottistefania lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT scandroglioannamara lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT lissonialfredo lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT fominskiyevgeny lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT rossolorenzo lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT tosidavide lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT mussovaleria lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT blasifrancesco lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT goriandrea lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues AT nosottimario lungtransplantforardsaftercovid19longtermoutcomesandconsiderationsaboutdetrimentalissues |