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Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues

During the first outbreak of COVID-19 in Italy, based on the only few cases reported from a Chinese centre at the time, we performed lung transplantation in two patients with irreversible acute respiratory distress syndrome (ARDS) after COVID-19 at our centre. After two years, we report the outcomes...

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Autores principales: Palleschi, Alessandro, Crotti, Stefania, Scandroglio, Anna Mara, Lissoni, Alfredo, Fominskiy, Evgeny, Rosso, Lorenzo, Tosi, Davide, Musso, Valeria, Blasi, Francesco, Gori, Andrea, Nosotti, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409702/
https://www.ncbi.nlm.nih.gov/pubmed/36012993
http://dx.doi.org/10.3390/jcm11164754
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author Palleschi, Alessandro
Crotti, Stefania
Scandroglio, Anna Mara
Lissoni, Alfredo
Fominskiy, Evgeny
Rosso, Lorenzo
Tosi, Davide
Musso, Valeria
Blasi, Francesco
Gori, Andrea
Nosotti, Mario
author_facet Palleschi, Alessandro
Crotti, Stefania
Scandroglio, Anna Mara
Lissoni, Alfredo
Fominskiy, Evgeny
Rosso, Lorenzo
Tosi, Davide
Musso, Valeria
Blasi, Francesco
Gori, Andrea
Nosotti, Mario
author_sort Palleschi, Alessandro
collection PubMed
description During the first outbreak of COVID-19 in Italy, based on the only few cases reported from a Chinese centre at the time, we performed lung transplantation in two patients with irreversible acute respiratory distress syndrome (ARDS) after COVID-19 at our centre. After two years, we report the outcomes of these cases and some considerations. The first patient, an 18-year-old male, is in excellent conditions twenty-four months after surgery. The second patient was a 48-year-old man; his airways were colonized by carbapenemase-producing klebsiella pneumoniae at the time of lung transplantation, and he had previously suffered from delirium and hallucinations in the intensive care unit. His postoperative clinical course was complicated by dysexecutive behaviour and then septic shock; he died 62 days after surgery. The recently reported experience of different transplantation centres has led to the inclusion of irreversible acute respiratory distress syndrome (ARDS) after COVID-19 among the indications for lung transplantation in carefully selected patients. Our results confirm the feasibility and the good long-term outcomes of lung transplantation for COVID-19-associated ARDS. Nonetheless, our experience corroborates the need for careful recipient selection: special attention must be paid to the single-organ dysfunction principle, the evaluation of any neuro-psychiatric disorder, and MDR germs colonization, before listing.
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spelling pubmed-94097022022-08-26 Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues Palleschi, Alessandro Crotti, Stefania Scandroglio, Anna Mara Lissoni, Alfredo Fominskiy, Evgeny Rosso, Lorenzo Tosi, Davide Musso, Valeria Blasi, Francesco Gori, Andrea Nosotti, Mario J Clin Med Case Report During the first outbreak of COVID-19 in Italy, based on the only few cases reported from a Chinese centre at the time, we performed lung transplantation in two patients with irreversible acute respiratory distress syndrome (ARDS) after COVID-19 at our centre. After two years, we report the outcomes of these cases and some considerations. The first patient, an 18-year-old male, is in excellent conditions twenty-four months after surgery. The second patient was a 48-year-old man; his airways were colonized by carbapenemase-producing klebsiella pneumoniae at the time of lung transplantation, and he had previously suffered from delirium and hallucinations in the intensive care unit. His postoperative clinical course was complicated by dysexecutive behaviour and then septic shock; he died 62 days after surgery. The recently reported experience of different transplantation centres has led to the inclusion of irreversible acute respiratory distress syndrome (ARDS) after COVID-19 among the indications for lung transplantation in carefully selected patients. Our results confirm the feasibility and the good long-term outcomes of lung transplantation for COVID-19-associated ARDS. Nonetheless, our experience corroborates the need for careful recipient selection: special attention must be paid to the single-organ dysfunction principle, the evaluation of any neuro-psychiatric disorder, and MDR germs colonization, before listing. MDPI 2022-08-15 /pmc/articles/PMC9409702/ /pubmed/36012993 http://dx.doi.org/10.3390/jcm11164754 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Palleschi, Alessandro
Crotti, Stefania
Scandroglio, Anna Mara
Lissoni, Alfredo
Fominskiy, Evgeny
Rosso, Lorenzo
Tosi, Davide
Musso, Valeria
Blasi, Francesco
Gori, Andrea
Nosotti, Mario
Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
title Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
title_full Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
title_fullStr Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
title_full_unstemmed Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
title_short Lung Transplant for ARDS after COVID-19: Long-Term Outcomes and Considerations about Detrimental Issues
title_sort lung transplant for ards after covid-19: long-term outcomes and considerations about detrimental issues
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409702/
https://www.ncbi.nlm.nih.gov/pubmed/36012993
http://dx.doi.org/10.3390/jcm11164754
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