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Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study

Objectives: We aimed to examine whether metformin (MET) use is associated with a reduced risk of total knee arthroplasty (TKA) and low severity of knee pain in patients with knee osteoarthritis (OA) and diabetes and/or obesity. Methods: Participants diagnosed with knee OA and diabetes and/or obesity...

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Autores principales: Chen, Shibo, Ruan, Guangfeng, Zeng, Muhui, Chen, Tianyu, Cao, Peihua, Zhang, Yan, Li, Jia, Wang, Xiaoshuai, Li, Shengfa, Tang, Su’an, Lu, Shilong, Fan, Tianxiang, Li, Yang, Han, Weiyu, Tan, Jianye, Ding, Changhai, Zhu, Zhaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409735/
https://www.ncbi.nlm.nih.gov/pubmed/36013035
http://dx.doi.org/10.3390/jcm11164796
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author Chen, Shibo
Ruan, Guangfeng
Zeng, Muhui
Chen, Tianyu
Cao, Peihua
Zhang, Yan
Li, Jia
Wang, Xiaoshuai
Li, Shengfa
Tang, Su’an
Lu, Shilong
Fan, Tianxiang
Li, Yang
Han, Weiyu
Tan, Jianye
Ding, Changhai
Zhu, Zhaohua
author_facet Chen, Shibo
Ruan, Guangfeng
Zeng, Muhui
Chen, Tianyu
Cao, Peihua
Zhang, Yan
Li, Jia
Wang, Xiaoshuai
Li, Shengfa
Tang, Su’an
Lu, Shilong
Fan, Tianxiang
Li, Yang
Han, Weiyu
Tan, Jianye
Ding, Changhai
Zhu, Zhaohua
author_sort Chen, Shibo
collection PubMed
description Objectives: We aimed to examine whether metformin (MET) use is associated with a reduced risk of total knee arthroplasty (TKA) and low severity of knee pain in patients with knee osteoarthritis (OA) and diabetes and/or obesity. Methods: Participants diagnosed with knee OA and diabetes and/or obesity from June 2000 to July 2019 were selected from the information system of a local hospital. Regular MET users were defined as those with recorded prescriptions of MET or self-reported regular MET use for at least 6 months. TKA information was extracted from patients’ surgical records. Knee pain was assessed using the numeric rating scale. Log-binomial regression, linear regression, and propensity score weighting (PSW) were performed for statistical analyses. Results: A total of 862 participants were included in the analyses. After excluding missing data, there were 346 MET non-users and 362 MET users. MET use was significantly associated with a reduced risk of TKA (prevalence ratio: 0.26, 95% CI: 0.15 to 0.45, p < 0.001), after adjustment for age, gender, body mass index, various analgesics, and insurance status. MET use was significantly associated with a reduced degree of knee pain after being adjusted for the above covariates (β: −0.48, 95% CI: −0.91 to −0.05, p = 0.029). There was a significantly accumulative effect of MET use on the reduced risk of TKA. Conclusion: MET can be a potential therapeutic option for OA. Further clinical trials are needed to determine if MET can reduce the risk of TKA and the severity of knee pain in metabolic-associated OA patients.
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spelling pubmed-94097352022-08-26 Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study Chen, Shibo Ruan, Guangfeng Zeng, Muhui Chen, Tianyu Cao, Peihua Zhang, Yan Li, Jia Wang, Xiaoshuai Li, Shengfa Tang, Su’an Lu, Shilong Fan, Tianxiang Li, Yang Han, Weiyu Tan, Jianye Ding, Changhai Zhu, Zhaohua J Clin Med Article Objectives: We aimed to examine whether metformin (MET) use is associated with a reduced risk of total knee arthroplasty (TKA) and low severity of knee pain in patients with knee osteoarthritis (OA) and diabetes and/or obesity. Methods: Participants diagnosed with knee OA and diabetes and/or obesity from June 2000 to July 2019 were selected from the information system of a local hospital. Regular MET users were defined as those with recorded prescriptions of MET or self-reported regular MET use for at least 6 months. TKA information was extracted from patients’ surgical records. Knee pain was assessed using the numeric rating scale. Log-binomial regression, linear regression, and propensity score weighting (PSW) were performed for statistical analyses. Results: A total of 862 participants were included in the analyses. After excluding missing data, there were 346 MET non-users and 362 MET users. MET use was significantly associated with a reduced risk of TKA (prevalence ratio: 0.26, 95% CI: 0.15 to 0.45, p < 0.001), after adjustment for age, gender, body mass index, various analgesics, and insurance status. MET use was significantly associated with a reduced degree of knee pain after being adjusted for the above covariates (β: −0.48, 95% CI: −0.91 to −0.05, p = 0.029). There was a significantly accumulative effect of MET use on the reduced risk of TKA. Conclusion: MET can be a potential therapeutic option for OA. Further clinical trials are needed to determine if MET can reduce the risk of TKA and the severity of knee pain in metabolic-associated OA patients. MDPI 2022-08-17 /pmc/articles/PMC9409735/ /pubmed/36013035 http://dx.doi.org/10.3390/jcm11164796 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Shibo
Ruan, Guangfeng
Zeng, Muhui
Chen, Tianyu
Cao, Peihua
Zhang, Yan
Li, Jia
Wang, Xiaoshuai
Li, Shengfa
Tang, Su’an
Lu, Shilong
Fan, Tianxiang
Li, Yang
Han, Weiyu
Tan, Jianye
Ding, Changhai
Zhu, Zhaohua
Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study
title Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study
title_full Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study
title_fullStr Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study
title_full_unstemmed Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study
title_short Association between Metformin Use and Risk of Total Knee Arthroplasty and Degree of Knee Pain in Knee Osteoarthritis Patients with Diabetes and/or Obesity: A Retrospective Study
title_sort association between metformin use and risk of total knee arthroplasty and degree of knee pain in knee osteoarthritis patients with diabetes and/or obesity: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409735/
https://www.ncbi.nlm.nih.gov/pubmed/36013035
http://dx.doi.org/10.3390/jcm11164796
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