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H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation

(1) Background: The heart-type fatty acid-binding protein (H-FABP) is a specific myocardial biomarker and high levels indicate ischemia regardless of patient-reported symptoms. Concurrently, major adverse cardiovascular events and surgery such as coronary artery by-pass grafting (CABG) cause substan...

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Autores principales: Al Namat, Razan, Al Namat, Dina, Ciocoiu, Manuela, Hînganu, Marius Valeriu, Șorodoc, Laurențiu, Șorodoc, Victorița, Foia, Liliana Georgeta, Florea, Laura, Vlad, Cristiana, Tănasă, Ana, Constantin, Mihai, Cioloca, Daniel, Bădescu, Minerva Codruța, Bazyani, Amin, Felea, Maura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409770/
https://www.ncbi.nlm.nih.gov/pubmed/36005406
http://dx.doi.org/10.3390/jcdd9080242
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author Al Namat, Razan
Al Namat, Dina
Ciocoiu, Manuela
Hînganu, Marius Valeriu
Șorodoc, Laurențiu
Șorodoc, Victorița
Foia, Liliana Georgeta
Florea, Laura
Vlad, Cristiana
Tănasă, Ana
Constantin, Mihai
Cioloca, Daniel
Bădescu, Minerva Codruța
Bazyani, Amin
Felea, Maura
author_facet Al Namat, Razan
Al Namat, Dina
Ciocoiu, Manuela
Hînganu, Marius Valeriu
Șorodoc, Laurențiu
Șorodoc, Victorița
Foia, Liliana Georgeta
Florea, Laura
Vlad, Cristiana
Tănasă, Ana
Constantin, Mihai
Cioloca, Daniel
Bădescu, Minerva Codruța
Bazyani, Amin
Felea, Maura
author_sort Al Namat, Razan
collection PubMed
description (1) Background: The heart-type fatty acid-binding protein (H-FABP) is a specific myocardial biomarker and high levels indicate ischemia regardless of patient-reported symptoms. Concurrently, major adverse cardiovascular events and surgery such as coronary artery by-pass grafting (CABG) cause substantial psycho-emotional distress e.g., depression and anxiety. Comprehensive cardiac rehabilitation is, therefore, essential to both physical and psychological recovery. (2) Methods: This is a unicentric, prospective study on 120 consecutive post-CABG patients undergoing a 6-month cardiac rehabilitation program based on physical exercise, Mediterranean diet principles, and Q10 coenzyme antioxidant supplements. H-FABP levels, depression, and anxiety scores (Hamilton HAM-D and HAM-A scales) were monitored after surgery and at 6 months. (3) Results: Mean H-FABP dropped from 60.56 to 4.81. Physical ability increased from 1–2 to 4–5 METS. Mean depression and anxiety improved from 15.88 to 6.96 and from 25.13 to 15.68, respectively. Median scores went down 50% for depression and 9% for anxiety. Explored associations between H-FABP and psycho-emotional status were statistically insignificant. (4) Conclusions: patients adhered to the program and improved significantly in all studied aspects. Clinical significance is discussed in the context of countries like Romania, where such programs are limited by systemic and financial constraints. Further research directions are identified.
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spelling pubmed-94097702022-08-26 H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation Al Namat, Razan Al Namat, Dina Ciocoiu, Manuela Hînganu, Marius Valeriu Șorodoc, Laurențiu Șorodoc, Victorița Foia, Liliana Georgeta Florea, Laura Vlad, Cristiana Tănasă, Ana Constantin, Mihai Cioloca, Daniel Bădescu, Minerva Codruța Bazyani, Amin Felea, Maura J Cardiovasc Dev Dis Article (1) Background: The heart-type fatty acid-binding protein (H-FABP) is a specific myocardial biomarker and high levels indicate ischemia regardless of patient-reported symptoms. Concurrently, major adverse cardiovascular events and surgery such as coronary artery by-pass grafting (CABG) cause substantial psycho-emotional distress e.g., depression and anxiety. Comprehensive cardiac rehabilitation is, therefore, essential to both physical and psychological recovery. (2) Methods: This is a unicentric, prospective study on 120 consecutive post-CABG patients undergoing a 6-month cardiac rehabilitation program based on physical exercise, Mediterranean diet principles, and Q10 coenzyme antioxidant supplements. H-FABP levels, depression, and anxiety scores (Hamilton HAM-D and HAM-A scales) were monitored after surgery and at 6 months. (3) Results: Mean H-FABP dropped from 60.56 to 4.81. Physical ability increased from 1–2 to 4–5 METS. Mean depression and anxiety improved from 15.88 to 6.96 and from 25.13 to 15.68, respectively. Median scores went down 50% for depression and 9% for anxiety. Explored associations between H-FABP and psycho-emotional status were statistically insignificant. (4) Conclusions: patients adhered to the program and improved significantly in all studied aspects. Clinical significance is discussed in the context of countries like Romania, where such programs are limited by systemic and financial constraints. Further research directions are identified. MDPI 2022-07-28 /pmc/articles/PMC9409770/ /pubmed/36005406 http://dx.doi.org/10.3390/jcdd9080242 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al Namat, Razan
Al Namat, Dina
Ciocoiu, Manuela
Hînganu, Marius Valeriu
Șorodoc, Laurențiu
Șorodoc, Victorița
Foia, Liliana Georgeta
Florea, Laura
Vlad, Cristiana
Tănasă, Ana
Constantin, Mihai
Cioloca, Daniel
Bădescu, Minerva Codruța
Bazyani, Amin
Felea, Maura
H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation
title H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation
title_full H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation
title_fullStr H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation
title_full_unstemmed H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation
title_short H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation
title_sort h-fabp levels and psycho-emotional improvement of cabg patients during cardiac rehabilitation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409770/
https://www.ncbi.nlm.nih.gov/pubmed/36005406
http://dx.doi.org/10.3390/jcdd9080242
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