Cargando…

Dual Targeting of the EGFR/HER2 Pathway in Combination with Systemic Chemotherapy in Refractory Pancreatic Cancer—The CONKO-008 Phase I Investigation

Background: Primary objective of this present trial was to define the maximum tolerable dose of lapatinib in combination with oxaliplatin, 5-fluorouracil, and folinic acid (OFF) in refractory pancreatic cancer. The secondary objective was to assess the safety and efficacy of lapatinib plus OFF. Meth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Striefler, Jana K., Stieler, Jens M., Neumann, Christopher C. M., Geisel, Dominik, Ghadjar, Pirus, Sinn, Marianne, Malinka, Thomas, Pratschke, Johann, Stintzing, Sebastian, Oettle, Helmut, Riess, Hanno, Pelzer, Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409879/ https://www.ncbi.nlm.nih.gov/pubmed/36013144 http://dx.doi.org/10.3390/jcm11164905

Ejemplares similares

Mucin-1 Protein Is a Prognostic Marker for Pancreatic Ductal Adenocarcinoma: Results From the CONKO-001 Study
por: Striefler, Jana Käthe, et al.
Publicado: (2021)

α-Smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study
por: Sinn, M, et al.
Publicado: (2014)

Rationale and design of PROSPECT-CONKO 004: a prospective, randomized trial of simultaneous pancreatic cancer treatment with enoxaparin and chemotherapy)
por: Riess, Hanno, et al.
Publicado: (2008)

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer – the CONKO 004 pilot trial
por: Pelzer, Uwe, et al.
Publicado: (2014)

Parenteral nutrition support for patients with pancreatic cancer. Results of a phase II study
por: Pelzer, Uwe, et al.
Publicado: (2010)

Tumour buds determine prognosis in resected pancreatic ductal adenocarcinoma
por: Lohneis, Philipp, et al.
Publicado: (2018)

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial
por: Hoyer, K., et al.
Publicado: (2021)

Dose-escalated radiotherapy for unresectable or locally recurrent pancreatic cancer: Dose volume analysis, toxicity and outcome of 28 consecutive patients
por: Zschaeck, Sebastian, et al.
Publicado: (2017)

Value of Carbohydrate Antigen 19-9 in Predicting Response and Therapy Control in Patients with Metastatic Pancreatic Cancer Undergoing First-Line Therapy
por: Pelzer, Uwe, et al.
Publicado: (2013)

Intensity-Modulated and Image-Guided Radiotherapy in Patients with Locally Advanced Inoperable Pancreatic Cancer after Preradiation Chemotherapy
por: Sinn, M., et al.
Publicado: (2014)

Consensus in determining the resectability of locally progressed pancreatic ductal adenocarcinoma – results of the Conko-007 multicenter trial
por: Wittel, U. A., et al.
Publicado: (2019)

Inflammation-Based Prognostic Scores in Pancreatic Cancer Patients—A Single-Center Analysis of 1294 Patients within the Last Decade
por: Neumann, Christopher C. M., et al.
Publicado: (2023)

R0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007± trial
por: Fietkau, R., et al.
Publicado: (2020)

Influence of Baseline CT Body Composition Parameters on Survival in Patients with Pancreatic Adenocarcinoma
por: Beetz, Nick Lasse, et al.
Publicado: (2022)

The Falciform Ligament for Mesenteric and Portal Vein Reconstruction in Local Advanced Pancreatic Tumor: A Surgical Guide and Single-Center Experience
por: Malinka, T., et al.
Publicado: (2018)

Development of a Novel Dorsal Incision Only Invagination Type Pancreatogastrostomy (Charité-PG) Following Open Pancreaticoduodenectomy—A Single Centre Experience
por: Timmermann, Lea, et al.
Publicado: (2021)

Impact of Smoking, Body Weight, Diabetes, Hypertension and Kidney Dysfunction on Survival in Pancreatic Cancer Patients—A Single Center Analysis of 2323 Patients within the Last Decade
por: Neumann, Christopher C. M., et al.
Publicado: (2023)

Perineural Invasion in Pancreatic Ductal Adenocarcinoma (PDAC): A Saboteur of Curative Intended Therapies?
por: Felsenstein, Matthäus, et al.
Publicado: (2022)

Correction: Felsenstein M. et al. Perineural Invasion in Pancreatic Ductal Adenocarcinoma (PDAC): A Saboteur of Curative Intended Therapies? J. Clin. Med. 2022, 11, 2367
por: Felsenstein, Matthäus, et al.
Publicado: (2023)

Hadron calorimeter of ATLAS 008
por: Chernykh, S, et al.
Publicado: (1994)

Comment on: α-smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study
por: Sahin, I H, et al.
Publicado: (2015)

Oncologic Thermoradiotherapy: Need for Evidence, Harmonisation, and Innovation
por: Bodis, Stephan, et al.
Publicado: (2022)

Detection of Ki-ras mutations in tissue and plasma samples of patients with pancreatic cancer using PNA-mediated PCR clamping and hybridisation probes
por: Däbritz, J, et al.
Publicado: (2005)

Analysis of outcomes and predictors of long-term survival following resection for retroperitoneal sarcoma
por: Malinka, Thomas, et al.
Publicado: (2019)

Implementation of Robotic Assistance in Pancreatic Surgery: Experiences from the First 101 Consecutive Cases
por: Timmermann, Lea, et al.
Publicado: (2021)

Postoperative Radiotherapy after Radical Prostatectomy: Indications and Open Questions
por: Ghadjar, Pirus, et al.
Publicado: (2012)

Elevated reticulocyte count – a clue to the diagnosis of haemolytic-uraemic syndrome (HUS) associated with gemcitabine therapy for metastatic duodenal papillary carcinoma: a case report
por: Serke, S, et al.
Publicado: (1999)

008 se va con la murga
por: Campoamor, María José
Publicado: (1986)

AB008. Management of fertility post cancer
por: Smith, James
Publicado: (2016)

AB008. Treatment of retroperitoneoscopic adrenalectomy for pheochromocytoma
por: Li, Zeliang
Publicado: (2017)

Challenges of single-stage pancreatoduodenectomy: how to address pancreatogastrostomies with robotic-assisted surgery
por: Timmermann, Lea, et al.
Publicado: (2021)

Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland: a pilot study
por: Goldblum, David, et al.
Publicado: (2008)

Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation
por: Ghadjar, Pirus, et al.
Publicado: (2015)

P02-008 - Dramatic response to canakinumab in MKD
por: Makay, B, et al.
Publicado: (2013)

PW03-008 – Mitochondrial disturbances in Schnitzler syndrome
por: Sediva, A, et al.
Publicado: (2013)

PW01-008 – The inflammasome and secretory pathways in FMF
por: Orak, B, et al.
Publicado: (2013)

P03-008 - Gastrointestinal involvement in Behçet’s syndrome
por: Hatemi, I, et al.
Publicado: (2013)

Development of Streptomyces sp. FR-008 as an emerging chassis()
por: Liu, Qian, et al.
Publicado: (2016)

Complete Genome Sequence of Vibrio coralliilyticus OCN008
por: Lydick, Victoria N., et al.
Publicado: (2020)

Clinically significant bleeding in incurable cancer patients: effectiveness of hemostatic radiotherapy
por: Cihoric, Nikola, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kkakm2qrcjntji0gnnl5adeqfb