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Coccidioides Species: A Review of Basic Research: 2022

Coccidioides immitis and posadasii are closely related fungal species that cause coccidioidomycosis. These dimorphic organisms cause disease in immunocompetent as well as immunocompromised individuals and as much as 40% of the population is infected in the endemic area. Although most infections reso...

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Autores principales: Kirkland, Theo N., Stevens, David A., Hung, Chiung-Yu, Beyhan, Sinem, Taylor, John W., Shubitz, Lisa F., Duttke, Sascha H., Heidari, Arash, Johnson, Royce H., Deresinski, Stanley C., Lauer, Antje, Fierer, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409882/
https://www.ncbi.nlm.nih.gov/pubmed/36012847
http://dx.doi.org/10.3390/jof8080859
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author Kirkland, Theo N.
Stevens, David A.
Hung, Chiung-Yu
Beyhan, Sinem
Taylor, John W.
Shubitz, Lisa F.
Duttke, Sascha H.
Heidari, Arash
Johnson, Royce H.
Deresinski, Stanley C.
Lauer, Antje
Fierer, Joshua
author_facet Kirkland, Theo N.
Stevens, David A.
Hung, Chiung-Yu
Beyhan, Sinem
Taylor, John W.
Shubitz, Lisa F.
Duttke, Sascha H.
Heidari, Arash
Johnson, Royce H.
Deresinski, Stanley C.
Lauer, Antje
Fierer, Joshua
author_sort Kirkland, Theo N.
collection PubMed
description Coccidioides immitis and posadasii are closely related fungal species that cause coccidioidomycosis. These dimorphic organisms cause disease in immunocompetent as well as immunocompromised individuals and as much as 40% of the population is infected in the endemic area. Although most infections resolve spontaneously, the infection can be prolonged and, in some instances, fatal. Coccidioides has been studied for more than 100 years and many aspects of the organism and the disease it causes have been investigated. There are over 500 manuscripts concerning Coccidioides (excluding clinical articles) referenced in PubMed over the past 50 years, so there is a large body of evidence to review. We reviewed the most accurate and informative basic research studies of these fungi including some seminal older studies as well as an extensive review of current research. This is an attempt to gather the most important basic research studies about this fungus into one publication. To focus this review, we will discuss the mycology of the organism exclusively rather than the studies of the host response or clinical studies. We hope that this review will be a useful resource to those interested in Coccidioides and coccidioidomycosis.
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spelling pubmed-94098822022-08-26 Coccidioides Species: A Review of Basic Research: 2022 Kirkland, Theo N. Stevens, David A. Hung, Chiung-Yu Beyhan, Sinem Taylor, John W. Shubitz, Lisa F. Duttke, Sascha H. Heidari, Arash Johnson, Royce H. Deresinski, Stanley C. Lauer, Antje Fierer, Joshua J Fungi (Basel) Review Coccidioides immitis and posadasii are closely related fungal species that cause coccidioidomycosis. These dimorphic organisms cause disease in immunocompetent as well as immunocompromised individuals and as much as 40% of the population is infected in the endemic area. Although most infections resolve spontaneously, the infection can be prolonged and, in some instances, fatal. Coccidioides has been studied for more than 100 years and many aspects of the organism and the disease it causes have been investigated. There are over 500 manuscripts concerning Coccidioides (excluding clinical articles) referenced in PubMed over the past 50 years, so there is a large body of evidence to review. We reviewed the most accurate and informative basic research studies of these fungi including some seminal older studies as well as an extensive review of current research. This is an attempt to gather the most important basic research studies about this fungus into one publication. To focus this review, we will discuss the mycology of the organism exclusively rather than the studies of the host response or clinical studies. We hope that this review will be a useful resource to those interested in Coccidioides and coccidioidomycosis. MDPI 2022-08-16 /pmc/articles/PMC9409882/ /pubmed/36012847 http://dx.doi.org/10.3390/jof8080859 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kirkland, Theo N.
Stevens, David A.
Hung, Chiung-Yu
Beyhan, Sinem
Taylor, John W.
Shubitz, Lisa F.
Duttke, Sascha H.
Heidari, Arash
Johnson, Royce H.
Deresinski, Stanley C.
Lauer, Antje
Fierer, Joshua
Coccidioides Species: A Review of Basic Research: 2022
title Coccidioides Species: A Review of Basic Research: 2022
title_full Coccidioides Species: A Review of Basic Research: 2022
title_fullStr Coccidioides Species: A Review of Basic Research: 2022
title_full_unstemmed Coccidioides Species: A Review of Basic Research: 2022
title_short Coccidioides Species: A Review of Basic Research: 2022
title_sort coccidioides species: a review of basic research: 2022
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409882/
https://www.ncbi.nlm.nih.gov/pubmed/36012847
http://dx.doi.org/10.3390/jof8080859
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