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Clinical and Molecular Aspects of Iron Metabolism in Failing Myocytes

Heart failure (HF) is a common disease that causes significant limitations on the organism’s capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an essential role in heart failure by deteriorating the patient’s condition and is a prognostic marker indicating poor c...

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Detalles Bibliográficos
Autores principales: Kozłowska, Bogna, Sochanowicz, Barbara, Kraj, Leszek, Palusińska, Małgorzata, Kołsut, Piotr, Szymański, Łukasz, Lewicki, Sławomir, Kruszewski, Marcin, Załęska-Kocięcka, Marta, Leszek, Przemysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409945/
https://www.ncbi.nlm.nih.gov/pubmed/36013382
http://dx.doi.org/10.3390/life12081203
Descripción
Sumario:Heart failure (HF) is a common disease that causes significant limitations on the organism’s capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an essential role in heart failure by deteriorating the patient’s condition and is a prognostic marker indicating poor clinical outcomes. Therefore, in HF patients, supplementation of iron is recommended. However, iron treatment may cause adverse effects by increasing iron-related apoptosis and the production of oxygen radicals, which may cause additional heart damage. Furthermore, many knowledge gaps exist regarding the complex interplay between iron deficiency and heart failure. Here, we describe the current, comprehensive knowledge about the role of the proteins involved in iron metabolism. We will focus on the molecular and clinical aspects of iron deficiency in HF. We believe that summarizing the new advances in the translational and clinical research regarding iron deficiency in heart failure should broaden clinicians’ awareness of this comorbidity.