Cargando…
Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion
Objective: To determine if preoperative albumin-alkaline phosphatase ratio (AAPR) is predictive of clinical outcomes in patients with degenerative lumbar diseases undergoing lumbar fusion. Method: 326 patients undergoing posterior lumbar decompression and fusion were retrospectively analyzed. The cu...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409976/ https://www.ncbi.nlm.nih.gov/pubmed/36012961 http://dx.doi.org/10.3390/jcm11164719 |
_version_ | 1784774982187876352 |
---|---|
author | Guo, Youfeng Zhao, Haihong Xu, Haowei Gu, Huida Cao, Yang Li, Kai Li, Ting Hu, Tao Wang, Shanjin Zhao, Weidong Wu, Desheng |
author_facet | Guo, Youfeng Zhao, Haihong Xu, Haowei Gu, Huida Cao, Yang Li, Kai Li, Ting Hu, Tao Wang, Shanjin Zhao, Weidong Wu, Desheng |
author_sort | Guo, Youfeng |
collection | PubMed |
description | Objective: To determine if preoperative albumin-alkaline phosphatase ratio (AAPR) is predictive of clinical outcomes in patients with degenerative lumbar diseases undergoing lumbar fusion. Method: 326 patients undergoing posterior lumbar decompression and fusion were retrospectively analyzed. The cumulative grade was calculated by summing the Pfirrmann grades of all lumbar discs. Grouping was based on the 50th percentile of cumulative grade. The relationship between AAPR, intervertebral disc degeneration (IDD) severity, and fusion rate was explored using correlation analyses and logistic regression models. Meanwhile, the ROC curve evaluated the discrimination ability of AAPR in predicting severe degeneration and non-fusion. Results: High AAPR levels were significantly negatively correlated with severe degeneration and non-fusion rate. A multivariate binary logistic analysis revealed that high preoperative AAPR was an independent predictor of severe degeneration and postoperative non-fusion (OR: 0.114; 95% CI: 0.027–0.482; p = 0.003; OR: 0.003; 95% CI: 0.0003–0.022; p < 0.001). The models showed excellent discrimination and calibration. The areas under the curve (AUC) of severe degeneration and non-fusion identified by AAPR were 0.635 and 0.643. Conclusion: The AAPR can help predict the severity of disc degeneration and the likelihood of non-fusion. |
format | Online Article Text |
id | pubmed-9409976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94099762022-08-26 Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion Guo, Youfeng Zhao, Haihong Xu, Haowei Gu, Huida Cao, Yang Li, Kai Li, Ting Hu, Tao Wang, Shanjin Zhao, Weidong Wu, Desheng J Clin Med Article Objective: To determine if preoperative albumin-alkaline phosphatase ratio (AAPR) is predictive of clinical outcomes in patients with degenerative lumbar diseases undergoing lumbar fusion. Method: 326 patients undergoing posterior lumbar decompression and fusion were retrospectively analyzed. The cumulative grade was calculated by summing the Pfirrmann grades of all lumbar discs. Grouping was based on the 50th percentile of cumulative grade. The relationship between AAPR, intervertebral disc degeneration (IDD) severity, and fusion rate was explored using correlation analyses and logistic regression models. Meanwhile, the ROC curve evaluated the discrimination ability of AAPR in predicting severe degeneration and non-fusion. Results: High AAPR levels were significantly negatively correlated with severe degeneration and non-fusion rate. A multivariate binary logistic analysis revealed that high preoperative AAPR was an independent predictor of severe degeneration and postoperative non-fusion (OR: 0.114; 95% CI: 0.027–0.482; p = 0.003; OR: 0.003; 95% CI: 0.0003–0.022; p < 0.001). The models showed excellent discrimination and calibration. The areas under the curve (AUC) of severe degeneration and non-fusion identified by AAPR were 0.635 and 0.643. Conclusion: The AAPR can help predict the severity of disc degeneration and the likelihood of non-fusion. MDPI 2022-08-12 /pmc/articles/PMC9409976/ /pubmed/36012961 http://dx.doi.org/10.3390/jcm11164719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guo, Youfeng Zhao, Haihong Xu, Haowei Gu, Huida Cao, Yang Li, Kai Li, Ting Hu, Tao Wang, Shanjin Zhao, Weidong Wu, Desheng Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion |
title | Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion |
title_full | Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion |
title_fullStr | Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion |
title_full_unstemmed | Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion |
title_short | Albumin-to-Alkaline Phosphatase Ratio as a Prognostic Biomarker for Spinal Fusion in Lumbar Degenerative Diseases Patients Undergoing Lumbar Spinal Fusion |
title_sort | albumin-to-alkaline phosphatase ratio as a prognostic biomarker for spinal fusion in lumbar degenerative diseases patients undergoing lumbar spinal fusion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9409976/ https://www.ncbi.nlm.nih.gov/pubmed/36012961 http://dx.doi.org/10.3390/jcm11164719 |
work_keys_str_mv | AT guoyoufeng albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT zhaohaihong albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT xuhaowei albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT guhuida albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT caoyang albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT likai albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT liting albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT hutao albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT wangshanjin albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT zhaoweidong albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion AT wudesheng albumintoalkalinephosphataseratioasaprognosticbiomarkerforspinalfusioninlumbardegenerativediseasespatientsundergoinglumbarspinalfusion |