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The Delivery of mRNA Vaccines for Therapeutics
mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410089/ https://www.ncbi.nlm.nih.gov/pubmed/36013433 http://dx.doi.org/10.3390/life12081254 |
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author | Nitika, Wei, Jiao Hui, Ai-Min |
author_facet | Nitika, Wei, Jiao Hui, Ai-Min |
author_sort | Nitika, |
collection | PubMed |
description | mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier play an important role. mRNA vaccines can be delivered using lipid nanoparticles, polymers, peptides or naked mRNA. The vaccine efficacy is influenced by the appropriate delivery materials, formulation methods and selection of a proper administration route. In addition, co-delivery of several mRNAs could also be beneficial and enhance immunity against various variants of an infectious pathogen or several pathogens altogether. Here, we review the recent progress in the delivery methods, modes of delivery and patentable mRNA vaccine technologies. |
format | Online Article Text |
id | pubmed-9410089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94100892022-08-26 The Delivery of mRNA Vaccines for Therapeutics Nitika, Wei, Jiao Hui, Ai-Min Life (Basel) Review mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers. For effective vaccination, mRNA formulation, delivery method and composition of the mRNA carrier play an important role. mRNA vaccines can be delivered using lipid nanoparticles, polymers, peptides or naked mRNA. The vaccine efficacy is influenced by the appropriate delivery materials, formulation methods and selection of a proper administration route. In addition, co-delivery of several mRNAs could also be beneficial and enhance immunity against various variants of an infectious pathogen or several pathogens altogether. Here, we review the recent progress in the delivery methods, modes of delivery and patentable mRNA vaccine technologies. MDPI 2022-08-17 /pmc/articles/PMC9410089/ /pubmed/36013433 http://dx.doi.org/10.3390/life12081254 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nitika, Wei, Jiao Hui, Ai-Min The Delivery of mRNA Vaccines for Therapeutics |
title | The Delivery of mRNA Vaccines for Therapeutics |
title_full | The Delivery of mRNA Vaccines for Therapeutics |
title_fullStr | The Delivery of mRNA Vaccines for Therapeutics |
title_full_unstemmed | The Delivery of mRNA Vaccines for Therapeutics |
title_short | The Delivery of mRNA Vaccines for Therapeutics |
title_sort | delivery of mrna vaccines for therapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410089/ https://www.ncbi.nlm.nih.gov/pubmed/36013433 http://dx.doi.org/10.3390/life12081254 |
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