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Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
Uterine sarcomas occur very rarely in young women. Hysterectomy, which is a standard treatment, may not be acceptable for those patients, especially nulliparous women. Fertility-sparing management may be an alternative. The aim of the study was to assess fertility-sparing management in patients with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410102/ https://www.ncbi.nlm.nih.gov/pubmed/36012998 http://dx.doi.org/10.3390/jcm11164761 |
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author | Piątek, Szymon Szymusik, Iwona Dańska-Bidzińska, Anna Ołtarzewski, Mariusz Trojan, Gabriela Bidziński, Mariusz |
author_facet | Piątek, Szymon Szymusik, Iwona Dańska-Bidzińska, Anna Ołtarzewski, Mariusz Trojan, Gabriela Bidziński, Mariusz |
author_sort | Piątek, Szymon |
collection | PubMed |
description | Uterine sarcomas occur very rarely in young women. Hysterectomy, which is a standard treatment, may not be acceptable for those patients, especially nulliparous women. Fertility-sparing management may be an alternative. The aim of the study was to assess fertility-sparing management in patients with uterine sarcoma. Eleven patients were eligible for the study. Histopathologic types of the tumor included: adenosarcoma (n = 3), low-grade endometrial stromal sarcoma (n = 3), low-grade myofibroblastic sarcoma (n = 1), leiomyosarcoma (n = 1), leiomyosarcoma myxoides (n = 1), rhabdomyosarcoma (n = 1), high grade endometrial stromal sarcoma (n = 1). The mean age of the patients at the time of diagnosis was 27.4 years (range: 17–35) and the average follow-up 61 months (range: 12–158). Six patients received adjuvant treatment: megestrol (n = 5) and chemotherapy (n = 1). Recurrence was diagnosed in five cases. Median time to recurrence was 35 months (range: 8–90). Three patients conceived spontaneously following treatment and gave at least one live birth. In total, five full-term pregnancies were recorded and five healthy children were born. Fertility-sparing management may be considered in some patients with uterine sarcoma; however, it may not be appropriate in high-grade endometrial stromal sarcoma. Patients with adenosarcoma may have a low chance of childbearing. |
format | Online Article Text |
id | pubmed-9410102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94101022022-08-26 Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma Piątek, Szymon Szymusik, Iwona Dańska-Bidzińska, Anna Ołtarzewski, Mariusz Trojan, Gabriela Bidziński, Mariusz J Clin Med Article Uterine sarcomas occur very rarely in young women. Hysterectomy, which is a standard treatment, may not be acceptable for those patients, especially nulliparous women. Fertility-sparing management may be an alternative. The aim of the study was to assess fertility-sparing management in patients with uterine sarcoma. Eleven patients were eligible for the study. Histopathologic types of the tumor included: adenosarcoma (n = 3), low-grade endometrial stromal sarcoma (n = 3), low-grade myofibroblastic sarcoma (n = 1), leiomyosarcoma (n = 1), leiomyosarcoma myxoides (n = 1), rhabdomyosarcoma (n = 1), high grade endometrial stromal sarcoma (n = 1). The mean age of the patients at the time of diagnosis was 27.4 years (range: 17–35) and the average follow-up 61 months (range: 12–158). Six patients received adjuvant treatment: megestrol (n = 5) and chemotherapy (n = 1). Recurrence was diagnosed in five cases. Median time to recurrence was 35 months (range: 8–90). Three patients conceived spontaneously following treatment and gave at least one live birth. In total, five full-term pregnancies were recorded and five healthy children were born. Fertility-sparing management may be considered in some patients with uterine sarcoma; however, it may not be appropriate in high-grade endometrial stromal sarcoma. Patients with adenosarcoma may have a low chance of childbearing. MDPI 2022-08-15 /pmc/articles/PMC9410102/ /pubmed/36012998 http://dx.doi.org/10.3390/jcm11164761 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Piątek, Szymon Szymusik, Iwona Dańska-Bidzińska, Anna Ołtarzewski, Mariusz Trojan, Gabriela Bidziński, Mariusz Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma |
title | Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma |
title_full | Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma |
title_fullStr | Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma |
title_full_unstemmed | Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma |
title_short | Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma |
title_sort | fertility-sparing management may be considered in young women with uterine sarcoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410102/ https://www.ncbi.nlm.nih.gov/pubmed/36012998 http://dx.doi.org/10.3390/jcm11164761 |
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