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Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma

Uterine sarcomas occur very rarely in young women. Hysterectomy, which is a standard treatment, may not be acceptable for those patients, especially nulliparous women. Fertility-sparing management may be an alternative. The aim of the study was to assess fertility-sparing management in patients with...

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Autores principales: Piątek, Szymon, Szymusik, Iwona, Dańska-Bidzińska, Anna, Ołtarzewski, Mariusz, Trojan, Gabriela, Bidziński, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410102/
https://www.ncbi.nlm.nih.gov/pubmed/36012998
http://dx.doi.org/10.3390/jcm11164761
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author Piątek, Szymon
Szymusik, Iwona
Dańska-Bidzińska, Anna
Ołtarzewski, Mariusz
Trojan, Gabriela
Bidziński, Mariusz
author_facet Piątek, Szymon
Szymusik, Iwona
Dańska-Bidzińska, Anna
Ołtarzewski, Mariusz
Trojan, Gabriela
Bidziński, Mariusz
author_sort Piątek, Szymon
collection PubMed
description Uterine sarcomas occur very rarely in young women. Hysterectomy, which is a standard treatment, may not be acceptable for those patients, especially nulliparous women. Fertility-sparing management may be an alternative. The aim of the study was to assess fertility-sparing management in patients with uterine sarcoma. Eleven patients were eligible for the study. Histopathologic types of the tumor included: adenosarcoma (n = 3), low-grade endometrial stromal sarcoma (n = 3), low-grade myofibroblastic sarcoma (n = 1), leiomyosarcoma (n = 1), leiomyosarcoma myxoides (n = 1), rhabdomyosarcoma (n = 1), high grade endometrial stromal sarcoma (n = 1). The mean age of the patients at the time of diagnosis was 27.4 years (range: 17–35) and the average follow-up 61 months (range: 12–158). Six patients received adjuvant treatment: megestrol (n = 5) and chemotherapy (n = 1). Recurrence was diagnosed in five cases. Median time to recurrence was 35 months (range: 8–90). Three patients conceived spontaneously following treatment and gave at least one live birth. In total, five full-term pregnancies were recorded and five healthy children were born. Fertility-sparing management may be considered in some patients with uterine sarcoma; however, it may not be appropriate in high-grade endometrial stromal sarcoma. Patients with adenosarcoma may have a low chance of childbearing.
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spelling pubmed-94101022022-08-26 Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma Piątek, Szymon Szymusik, Iwona Dańska-Bidzińska, Anna Ołtarzewski, Mariusz Trojan, Gabriela Bidziński, Mariusz J Clin Med Article Uterine sarcomas occur very rarely in young women. Hysterectomy, which is a standard treatment, may not be acceptable for those patients, especially nulliparous women. Fertility-sparing management may be an alternative. The aim of the study was to assess fertility-sparing management in patients with uterine sarcoma. Eleven patients were eligible for the study. Histopathologic types of the tumor included: adenosarcoma (n = 3), low-grade endometrial stromal sarcoma (n = 3), low-grade myofibroblastic sarcoma (n = 1), leiomyosarcoma (n = 1), leiomyosarcoma myxoides (n = 1), rhabdomyosarcoma (n = 1), high grade endometrial stromal sarcoma (n = 1). The mean age of the patients at the time of diagnosis was 27.4 years (range: 17–35) and the average follow-up 61 months (range: 12–158). Six patients received adjuvant treatment: megestrol (n = 5) and chemotherapy (n = 1). Recurrence was diagnosed in five cases. Median time to recurrence was 35 months (range: 8–90). Three patients conceived spontaneously following treatment and gave at least one live birth. In total, five full-term pregnancies were recorded and five healthy children were born. Fertility-sparing management may be considered in some patients with uterine sarcoma; however, it may not be appropriate in high-grade endometrial stromal sarcoma. Patients with adenosarcoma may have a low chance of childbearing. MDPI 2022-08-15 /pmc/articles/PMC9410102/ /pubmed/36012998 http://dx.doi.org/10.3390/jcm11164761 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piątek, Szymon
Szymusik, Iwona
Dańska-Bidzińska, Anna
Ołtarzewski, Mariusz
Trojan, Gabriela
Bidziński, Mariusz
Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
title Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
title_full Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
title_fullStr Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
title_full_unstemmed Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
title_short Fertility-Sparing Management May Be Considered in Young Women with Uterine Sarcoma
title_sort fertility-sparing management may be considered in young women with uterine sarcoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410102/
https://www.ncbi.nlm.nih.gov/pubmed/36012998
http://dx.doi.org/10.3390/jcm11164761
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