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A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers

Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescen...

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Autores principales: Adl Amini, Dominik, Moser, Manuel, Chiapparelli, Erika, Oezel, Lisa, Zhu, Jiaqi, Okano, Ichiro, Shue, Jennifer, Sama, Andrew A., Cammisa, Frank P., Girardi, Federico P., Hughes, Alexander P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410107/
https://www.ncbi.nlm.nih.gov/pubmed/36012948
http://dx.doi.org/10.3390/jcm11164709
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author Adl Amini, Dominik
Moser, Manuel
Chiapparelli, Erika
Oezel, Lisa
Zhu, Jiaqi
Okano, Ichiro
Shue, Jennifer
Sama, Andrew A.
Cammisa, Frank P.
Girardi, Federico P.
Hughes, Alexander P.
author_facet Adl Amini, Dominik
Moser, Manuel
Chiapparelli, Erika
Oezel, Lisa
Zhu, Jiaqi
Okano, Ichiro
Shue, Jennifer
Sama, Andrew A.
Cammisa, Frank P.
Girardi, Federico P.
Hughes, Alexander P.
author_sort Adl Amini, Dominik
collection PubMed
description Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescence (SAF) AGE devices. Methods: Healthy volunteers were enrolled in a prospective study at a single academic institution. Each participant underwent SAF analysis by two different, commercially available devices on two occasions, 14 days apart. Upon enrollment, a general survey about the participant’s lifestyle and health status was completed and followed up on for any changes at timepoint two. Results: In total, 40 participants (F:M ratio 5:3) with an average age of 39.0 ± 12.5 years were analyzed. For the AGE reader (skin) and AGE sensor (fingertip), both intrarater reliability and two-timepoint agreement were excellent with an interclass correlation coefficient (ICC) > 0.90 and a strong correlation within both machines. However, there was no correlation between both machines for either timepoint. In total, 4 participants were identified as outliers above the +2SD. Additionally, 5 participants with dark-colored skin could not be measured with the AGE reader at timepoint one and 4 at timepoint two. In contrast, all participants were able to undergo SAF analysis with the AGE sensor, irrespective of their skin type. Conclusions: Both machines showed excellent intrarater reliability and two-timepoint agreement, but the skin AGE reader might have limited applicability in individuals with dark-colored skin. Future research on AGEs might take our findings into consideration.
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spelling pubmed-94101072022-08-26 A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers Adl Amini, Dominik Moser, Manuel Chiapparelli, Erika Oezel, Lisa Zhu, Jiaqi Okano, Ichiro Shue, Jennifer Sama, Andrew A. Cammisa, Frank P. Girardi, Federico P. Hughes, Alexander P. J Clin Med Article Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescence (SAF) AGE devices. Methods: Healthy volunteers were enrolled in a prospective study at a single academic institution. Each participant underwent SAF analysis by two different, commercially available devices on two occasions, 14 days apart. Upon enrollment, a general survey about the participant’s lifestyle and health status was completed and followed up on for any changes at timepoint two. Results: In total, 40 participants (F:M ratio 5:3) with an average age of 39.0 ± 12.5 years were analyzed. For the AGE reader (skin) and AGE sensor (fingertip), both intrarater reliability and two-timepoint agreement were excellent with an interclass correlation coefficient (ICC) > 0.90 and a strong correlation within both machines. However, there was no correlation between both machines for either timepoint. In total, 4 participants were identified as outliers above the +2SD. Additionally, 5 participants with dark-colored skin could not be measured with the AGE reader at timepoint one and 4 at timepoint two. In contrast, all participants were able to undergo SAF analysis with the AGE sensor, irrespective of their skin type. Conclusions: Both machines showed excellent intrarater reliability and two-timepoint agreement, but the skin AGE reader might have limited applicability in individuals with dark-colored skin. Future research on AGEs might take our findings into consideration. MDPI 2022-08-12 /pmc/articles/PMC9410107/ /pubmed/36012948 http://dx.doi.org/10.3390/jcm11164709 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Adl Amini, Dominik
Moser, Manuel
Chiapparelli, Erika
Oezel, Lisa
Zhu, Jiaqi
Okano, Ichiro
Shue, Jennifer
Sama, Andrew A.
Cammisa, Frank P.
Girardi, Federico P.
Hughes, Alexander P.
A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
title A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
title_full A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
title_fullStr A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
title_full_unstemmed A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
title_short A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
title_sort prospective analysis of skin and fingertip advanced glycation end-product devices in healthy volunteers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410107/
https://www.ncbi.nlm.nih.gov/pubmed/36012948
http://dx.doi.org/10.3390/jcm11164709
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