Cargando…
A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers
Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescen...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410107/ https://www.ncbi.nlm.nih.gov/pubmed/36012948 http://dx.doi.org/10.3390/jcm11164709 |
_version_ | 1784775014025789440 |
---|---|
author | Adl Amini, Dominik Moser, Manuel Chiapparelli, Erika Oezel, Lisa Zhu, Jiaqi Okano, Ichiro Shue, Jennifer Sama, Andrew A. Cammisa, Frank P. Girardi, Federico P. Hughes, Alexander P. |
author_facet | Adl Amini, Dominik Moser, Manuel Chiapparelli, Erika Oezel, Lisa Zhu, Jiaqi Okano, Ichiro Shue, Jennifer Sama, Andrew A. Cammisa, Frank P. Girardi, Federico P. Hughes, Alexander P. |
author_sort | Adl Amini, Dominik |
collection | PubMed |
description | Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescence (SAF) AGE devices. Methods: Healthy volunteers were enrolled in a prospective study at a single academic institution. Each participant underwent SAF analysis by two different, commercially available devices on two occasions, 14 days apart. Upon enrollment, a general survey about the participant’s lifestyle and health status was completed and followed up on for any changes at timepoint two. Results: In total, 40 participants (F:M ratio 5:3) with an average age of 39.0 ± 12.5 years were analyzed. For the AGE reader (skin) and AGE sensor (fingertip), both intrarater reliability and two-timepoint agreement were excellent with an interclass correlation coefficient (ICC) > 0.90 and a strong correlation within both machines. However, there was no correlation between both machines for either timepoint. In total, 4 participants were identified as outliers above the +2SD. Additionally, 5 participants with dark-colored skin could not be measured with the AGE reader at timepoint one and 4 at timepoint two. In contrast, all participants were able to undergo SAF analysis with the AGE sensor, irrespective of their skin type. Conclusions: Both machines showed excellent intrarater reliability and two-timepoint agreement, but the skin AGE reader might have limited applicability in individuals with dark-colored skin. Future research on AGEs might take our findings into consideration. |
format | Online Article Text |
id | pubmed-9410107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94101072022-08-26 A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers Adl Amini, Dominik Moser, Manuel Chiapparelli, Erika Oezel, Lisa Zhu, Jiaqi Okano, Ichiro Shue, Jennifer Sama, Andrew A. Cammisa, Frank P. Girardi, Federico P. Hughes, Alexander P. J Clin Med Article Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescence (SAF) AGE devices. Methods: Healthy volunteers were enrolled in a prospective study at a single academic institution. Each participant underwent SAF analysis by two different, commercially available devices on two occasions, 14 days apart. Upon enrollment, a general survey about the participant’s lifestyle and health status was completed and followed up on for any changes at timepoint two. Results: In total, 40 participants (F:M ratio 5:3) with an average age of 39.0 ± 12.5 years were analyzed. For the AGE reader (skin) and AGE sensor (fingertip), both intrarater reliability and two-timepoint agreement were excellent with an interclass correlation coefficient (ICC) > 0.90 and a strong correlation within both machines. However, there was no correlation between both machines for either timepoint. In total, 4 participants were identified as outliers above the +2SD. Additionally, 5 participants with dark-colored skin could not be measured with the AGE reader at timepoint one and 4 at timepoint two. In contrast, all participants were able to undergo SAF analysis with the AGE sensor, irrespective of their skin type. Conclusions: Both machines showed excellent intrarater reliability and two-timepoint agreement, but the skin AGE reader might have limited applicability in individuals with dark-colored skin. Future research on AGEs might take our findings into consideration. MDPI 2022-08-12 /pmc/articles/PMC9410107/ /pubmed/36012948 http://dx.doi.org/10.3390/jcm11164709 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Adl Amini, Dominik Moser, Manuel Chiapparelli, Erika Oezel, Lisa Zhu, Jiaqi Okano, Ichiro Shue, Jennifer Sama, Andrew A. Cammisa, Frank P. Girardi, Federico P. Hughes, Alexander P. A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers |
title | A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers |
title_full | A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers |
title_fullStr | A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers |
title_full_unstemmed | A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers |
title_short | A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers |
title_sort | prospective analysis of skin and fingertip advanced glycation end-product devices in healthy volunteers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410107/ https://www.ncbi.nlm.nih.gov/pubmed/36012948 http://dx.doi.org/10.3390/jcm11164709 |
work_keys_str_mv | AT adlaminidominik aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT mosermanuel aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT chiapparellierika aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT oezellisa aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT zhujiaqi aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT okanoichiro aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT shuejennifer aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT samaandrewa aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT cammisafrankp aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT girardifedericop aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT hughesalexanderp aprospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT adlaminidominik prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT mosermanuel prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT chiapparellierika prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT oezellisa prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT zhujiaqi prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT okanoichiro prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT shuejennifer prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT samaandrewa prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT cammisafrankp prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT girardifedericop prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers AT hughesalexanderp prospectiveanalysisofskinandfingertipadvancedglycationendproductdevicesinhealthyvolunteers |