Cargando…
The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, a...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410123/ https://www.ncbi.nlm.nih.gov/pubmed/36013362 http://dx.doi.org/10.3390/life12081183 |
_version_ | 1784775017918103552 |
---|---|
author | Sorodoc, Victorita Sirbu, Oana Lionte, Catalina Haliga, Raluca Ecaterina Stoica, Alexandra Ceasovschih, Alexandr Petris, Ovidiu Rusalim Constantin, Mihai Costache, Irina Iuliana Petris, Antoniu Octavian Morariu, Paula Cristina Sorodoc, Laurentiu |
author_facet | Sorodoc, Victorita Sirbu, Oana Lionte, Catalina Haliga, Raluca Ecaterina Stoica, Alexandra Ceasovschih, Alexandr Petris, Ovidiu Rusalim Constantin, Mihai Costache, Irina Iuliana Petris, Antoniu Octavian Morariu, Paula Cristina Sorodoc, Laurentiu |
author_sort | Sorodoc, Victorita |
collection | PubMed |
description | In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, atrial fibrillation, or heart failure. Troponin is a biomarker that is widely used in the detection of acute coronary syndromes. It has a high specificity, although it is not exclusively associated with myocardial ischemia. The aim of this paper is to summarize published studies and to establish the role of troponin assays in the diagnosis of cardiotoxicity associated with various chemotherapeutic agents. Troponin has been shown to be a significant biomarker in the diagnosis of the cardiac dysfunction associated with several types of chemotherapeutic drugs: anthracyclines, anti-human epidermal growth factor receptor 2 treatment, and anti-vascular endothelial growth factor therapy. Based on the data available at this moment, troponin is useful for baseline risk assessment, the diagnosis of cardiotoxicity, and as a guide for the initiation of cardioprotective treatment. There are currently clear regulations regarding the timing of troponin surveillance depending on the patient’s risk of cardiotoxicity and the type of medication administered, but data on the cut-off values of this biomarker are still under investigation. |
format | Online Article Text |
id | pubmed-9410123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94101232022-08-26 The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity Sorodoc, Victorita Sirbu, Oana Lionte, Catalina Haliga, Raluca Ecaterina Stoica, Alexandra Ceasovschih, Alexandr Petris, Ovidiu Rusalim Constantin, Mihai Costache, Irina Iuliana Petris, Antoniu Octavian Morariu, Paula Cristina Sorodoc, Laurentiu Life (Basel) Review In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, atrial fibrillation, or heart failure. Troponin is a biomarker that is widely used in the detection of acute coronary syndromes. It has a high specificity, although it is not exclusively associated with myocardial ischemia. The aim of this paper is to summarize published studies and to establish the role of troponin assays in the diagnosis of cardiotoxicity associated with various chemotherapeutic agents. Troponin has been shown to be a significant biomarker in the diagnosis of the cardiac dysfunction associated with several types of chemotherapeutic drugs: anthracyclines, anti-human epidermal growth factor receptor 2 treatment, and anti-vascular endothelial growth factor therapy. Based on the data available at this moment, troponin is useful for baseline risk assessment, the diagnosis of cardiotoxicity, and as a guide for the initiation of cardioprotective treatment. There are currently clear regulations regarding the timing of troponin surveillance depending on the patient’s risk of cardiotoxicity and the type of medication administered, but data on the cut-off values of this biomarker are still under investigation. MDPI 2022-08-03 /pmc/articles/PMC9410123/ /pubmed/36013362 http://dx.doi.org/10.3390/life12081183 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sorodoc, Victorita Sirbu, Oana Lionte, Catalina Haliga, Raluca Ecaterina Stoica, Alexandra Ceasovschih, Alexandr Petris, Ovidiu Rusalim Constantin, Mihai Costache, Irina Iuliana Petris, Antoniu Octavian Morariu, Paula Cristina Sorodoc, Laurentiu The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity |
title | The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity |
title_full | The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity |
title_fullStr | The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity |
title_full_unstemmed | The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity |
title_short | The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity |
title_sort | value of troponin as a biomarker of chemotherapy-induced cardiotoxicity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410123/ https://www.ncbi.nlm.nih.gov/pubmed/36013362 http://dx.doi.org/10.3390/life12081183 |
work_keys_str_mv | AT sorodocvictorita thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT sirbuoana thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT liontecatalina thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT haligaralucaecaterina thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT stoicaalexandra thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT ceasovschihalexandr thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT petrisovidiurusalim thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT constantinmihai thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT costacheirinaiuliana thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT petrisantoniuoctavian thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT morariupaulacristina thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT sorodoclaurentiu thevalueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT sorodocvictorita valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT sirbuoana valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT liontecatalina valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT haligaralucaecaterina valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT stoicaalexandra valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT ceasovschihalexandr valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT petrisovidiurusalim valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT constantinmihai valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT costacheirinaiuliana valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT petrisantoniuoctavian valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT morariupaulacristina valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity AT sorodoclaurentiu valueoftroponinasabiomarkerofchemotherapyinducedcardiotoxicity |