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The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity

In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, a...

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Autores principales: Sorodoc, Victorita, Sirbu, Oana, Lionte, Catalina, Haliga, Raluca Ecaterina, Stoica, Alexandra, Ceasovschih, Alexandr, Petris, Ovidiu Rusalim, Constantin, Mihai, Costache, Irina Iuliana, Petris, Antoniu Octavian, Morariu, Paula Cristina, Sorodoc, Laurentiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410123/
https://www.ncbi.nlm.nih.gov/pubmed/36013362
http://dx.doi.org/10.3390/life12081183
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author Sorodoc, Victorita
Sirbu, Oana
Lionte, Catalina
Haliga, Raluca Ecaterina
Stoica, Alexandra
Ceasovschih, Alexandr
Petris, Ovidiu Rusalim
Constantin, Mihai
Costache, Irina Iuliana
Petris, Antoniu Octavian
Morariu, Paula Cristina
Sorodoc, Laurentiu
author_facet Sorodoc, Victorita
Sirbu, Oana
Lionte, Catalina
Haliga, Raluca Ecaterina
Stoica, Alexandra
Ceasovschih, Alexandr
Petris, Ovidiu Rusalim
Constantin, Mihai
Costache, Irina Iuliana
Petris, Antoniu Octavian
Morariu, Paula Cristina
Sorodoc, Laurentiu
author_sort Sorodoc, Victorita
collection PubMed
description In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, atrial fibrillation, or heart failure. Troponin is a biomarker that is widely used in the detection of acute coronary syndromes. It has a high specificity, although it is not exclusively associated with myocardial ischemia. The aim of this paper is to summarize published studies and to establish the role of troponin assays in the diagnosis of cardiotoxicity associated with various chemotherapeutic agents. Troponin has been shown to be a significant biomarker in the diagnosis of the cardiac dysfunction associated with several types of chemotherapeutic drugs: anthracyclines, anti-human epidermal growth factor receptor 2 treatment, and anti-vascular endothelial growth factor therapy. Based on the data available at this moment, troponin is useful for baseline risk assessment, the diagnosis of cardiotoxicity, and as a guide for the initiation of cardioprotective treatment. There are currently clear regulations regarding the timing of troponin surveillance depending on the patient’s risk of cardiotoxicity and the type of medication administered, but data on the cut-off values of this biomarker are still under investigation.
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spelling pubmed-94101232022-08-26 The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity Sorodoc, Victorita Sirbu, Oana Lionte, Catalina Haliga, Raluca Ecaterina Stoica, Alexandra Ceasovschih, Alexandr Petris, Ovidiu Rusalim Constantin, Mihai Costache, Irina Iuliana Petris, Antoniu Octavian Morariu, Paula Cristina Sorodoc, Laurentiu Life (Basel) Review In cancer survivors, cardiac dysfunction is the main cause of mortality. Cardiotoxicity represents a decline in cardiac function associated with cancer therapy, and the risk factors include smoking, dyslipidemia, an age of over 60 years, obesity, and a history of coronary artery disease, diabetes, atrial fibrillation, or heart failure. Troponin is a biomarker that is widely used in the detection of acute coronary syndromes. It has a high specificity, although it is not exclusively associated with myocardial ischemia. The aim of this paper is to summarize published studies and to establish the role of troponin assays in the diagnosis of cardiotoxicity associated with various chemotherapeutic agents. Troponin has been shown to be a significant biomarker in the diagnosis of the cardiac dysfunction associated with several types of chemotherapeutic drugs: anthracyclines, anti-human epidermal growth factor receptor 2 treatment, and anti-vascular endothelial growth factor therapy. Based on the data available at this moment, troponin is useful for baseline risk assessment, the diagnosis of cardiotoxicity, and as a guide for the initiation of cardioprotective treatment. There are currently clear regulations regarding the timing of troponin surveillance depending on the patient’s risk of cardiotoxicity and the type of medication administered, but data on the cut-off values of this biomarker are still under investigation. MDPI 2022-08-03 /pmc/articles/PMC9410123/ /pubmed/36013362 http://dx.doi.org/10.3390/life12081183 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sorodoc, Victorita
Sirbu, Oana
Lionte, Catalina
Haliga, Raluca Ecaterina
Stoica, Alexandra
Ceasovschih, Alexandr
Petris, Ovidiu Rusalim
Constantin, Mihai
Costache, Irina Iuliana
Petris, Antoniu Octavian
Morariu, Paula Cristina
Sorodoc, Laurentiu
The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
title The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
title_full The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
title_fullStr The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
title_full_unstemmed The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
title_short The Value of Troponin as a Biomarker of Chemotherapy-Induced Cardiotoxicity
title_sort value of troponin as a biomarker of chemotherapy-induced cardiotoxicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410123/
https://www.ncbi.nlm.nih.gov/pubmed/36013362
http://dx.doi.org/10.3390/life12081183
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