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Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community

Peripartum cardiomyopathy (PPCM) is idiopathic systolic congestive heart failure around pregnancy. Comparisons with matched controls are lacking. We investigated maternal characteristics and outcomes up to 12 months in a cohort admitted to Montefiore Health System in Bronx, New York 1999–2015 (n = 5...

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Autores principales: Wolfe, Diana S., Liu, Christina, Alboucai, Jack, Karten, Ariel, Mushi, Juliet, Yellin, Shira, Berkowitz, Julia L., Vega, Shayna, Felix, Nicole, Liaqat, Wasla, Kankaria, Rohan, Vorawandthanachai, Thammatat, Bortnick, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410188/
https://www.ncbi.nlm.nih.gov/pubmed/36005414
http://dx.doi.org/10.3390/jcdd9080250
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author Wolfe, Diana S.
Liu, Christina
Alboucai, Jack
Karten, Ariel
Mushi, Juliet
Yellin, Shira
Berkowitz, Julia L.
Vega, Shayna
Felix, Nicole
Liaqat, Wasla
Kankaria, Rohan
Vorawandthanachai, Thammatat
Bortnick, Anna E.
author_facet Wolfe, Diana S.
Liu, Christina
Alboucai, Jack
Karten, Ariel
Mushi, Juliet
Yellin, Shira
Berkowitz, Julia L.
Vega, Shayna
Felix, Nicole
Liaqat, Wasla
Kankaria, Rohan
Vorawandthanachai, Thammatat
Bortnick, Anna E.
author_sort Wolfe, Diana S.
collection PubMed
description Peripartum cardiomyopathy (PPCM) is idiopathic systolic congestive heart failure around pregnancy. Comparisons with matched controls are lacking. We investigated maternal characteristics and outcomes up to 12 months in a cohort admitted to Montefiore Health System in Bronx, New York 1999–2015 (n = 53 cases and n = 92 age and race-matched controls, >80% Black or Hispanic/Latina). Compared to peers, women with PPCM had more chronic hypertension (24.5% vs. 8.8%, p = 0.001), prior gestational hypertension (20.8% vs. 5.4%, p = 0.001), prior preeclampsia (17.0% vs. 3.3%, p = 0.001), familial dilated cardiomyopathy (5.7% vs. 0.0%, p = 0.04), smoking (15.1% vs. 2.2%, p = 0.001), lower summary socioeconomic scores (−4.12 (IQR −6.81, −2.13) vs. −1.62 (IQR −4.20, −0.74), p < 0.001), public insurance (67.9% vs. 29.3% p = 0.001), and frequent depressive symptoms. Women with PPCM were often admitted antepartum (34.0% vs. 18.5%, p = 0.001) and underwent Cesarean section (65.4% vs. 30.4%, p = 0.001), but had less preterm labor (27.3% vs. 51.1%, p = 0.001). Women were rarely treated with bromocriptine (3.8%), frequently underwent left ventricular assist device placement (9.4% and n = 2 with menorrhagia requiring transfusion and progesterone) or heart transplantation (3.8%), but there were no in-hospital deaths. In sum, women with PPCM had worse socioeconomic disadvantage and baseline health than matched peers. Programs addressing social determinants of health may be important for women at high risk of PPCM.
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spelling pubmed-94101882022-08-26 Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community Wolfe, Diana S. Liu, Christina Alboucai, Jack Karten, Ariel Mushi, Juliet Yellin, Shira Berkowitz, Julia L. Vega, Shayna Felix, Nicole Liaqat, Wasla Kankaria, Rohan Vorawandthanachai, Thammatat Bortnick, Anna E. J Cardiovasc Dev Dis Article Peripartum cardiomyopathy (PPCM) is idiopathic systolic congestive heart failure around pregnancy. Comparisons with matched controls are lacking. We investigated maternal characteristics and outcomes up to 12 months in a cohort admitted to Montefiore Health System in Bronx, New York 1999–2015 (n = 53 cases and n = 92 age and race-matched controls, >80% Black or Hispanic/Latina). Compared to peers, women with PPCM had more chronic hypertension (24.5% vs. 8.8%, p = 0.001), prior gestational hypertension (20.8% vs. 5.4%, p = 0.001), prior preeclampsia (17.0% vs. 3.3%, p = 0.001), familial dilated cardiomyopathy (5.7% vs. 0.0%, p = 0.04), smoking (15.1% vs. 2.2%, p = 0.001), lower summary socioeconomic scores (−4.12 (IQR −6.81, −2.13) vs. −1.62 (IQR −4.20, −0.74), p < 0.001), public insurance (67.9% vs. 29.3% p = 0.001), and frequent depressive symptoms. Women with PPCM were often admitted antepartum (34.0% vs. 18.5%, p = 0.001) and underwent Cesarean section (65.4% vs. 30.4%, p = 0.001), but had less preterm labor (27.3% vs. 51.1%, p = 0.001). Women were rarely treated with bromocriptine (3.8%), frequently underwent left ventricular assist device placement (9.4% and n = 2 with menorrhagia requiring transfusion and progesterone) or heart transplantation (3.8%), but there were no in-hospital deaths. In sum, women with PPCM had worse socioeconomic disadvantage and baseline health than matched peers. Programs addressing social determinants of health may be important for women at high risk of PPCM. MDPI 2022-08-06 /pmc/articles/PMC9410188/ /pubmed/36005414 http://dx.doi.org/10.3390/jcdd9080250 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wolfe, Diana S.
Liu, Christina
Alboucai, Jack
Karten, Ariel
Mushi, Juliet
Yellin, Shira
Berkowitz, Julia L.
Vega, Shayna
Felix, Nicole
Liaqat, Wasla
Kankaria, Rohan
Vorawandthanachai, Thammatat
Bortnick, Anna E.
Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community
title Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community
title_full Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community
title_fullStr Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community
title_full_unstemmed Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community
title_short Maternal Outcomes in Women with Peripartum Cardiomyopathy versus Age and Race-Matched Peers in an Urban US Community
title_sort maternal outcomes in women with peripartum cardiomyopathy versus age and race-matched peers in an urban us community
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410188/
https://www.ncbi.nlm.nih.gov/pubmed/36005414
http://dx.doi.org/10.3390/jcdd9080250
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