Cargando…

Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach

Background: Open partial horizontal laryngectomies (OPHL) are one of the surgical techniques used for the conservative management of laryngeal cancers. The aims of this study are to analyze the oncological and functional results of a group of patients affected by laryngeal squamous cell carcinoma (L...

Descripción completa

Detalles Bibliográficos
Autores principales: Colizza, Andrea, Ralli, Massimo, Di Stadio, Arianna, Cambria, Francesca, Zoccali, Federica, Cialente, Fabrizio, Angeletti, Diletta, Greco, Antonio, de Vincentiis, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410219/
https://www.ncbi.nlm.nih.gov/pubmed/36012980
http://dx.doi.org/10.3390/jcm11164741
_version_ 1784775040842072064
author Colizza, Andrea
Ralli, Massimo
Di Stadio, Arianna
Cambria, Francesca
Zoccali, Federica
Cialente, Fabrizio
Angeletti, Diletta
Greco, Antonio
de Vincentiis, Marco
author_facet Colizza, Andrea
Ralli, Massimo
Di Stadio, Arianna
Cambria, Francesca
Zoccali, Federica
Cialente, Fabrizio
Angeletti, Diletta
Greco, Antonio
de Vincentiis, Marco
author_sort Colizza, Andrea
collection PubMed
description Background: Open partial horizontal laryngectomies (OPHL) are one of the surgical techniques used for the conservative management of laryngeal cancers. The aims of this study are to analyze the oncological and functional results of a group of patients affected by laryngeal squamous cell carcinoma (LSCC) treated with OPHL, performed using a minimally invasive technique. Methods: This is a prospective case–control study. We enrolled 17 consecutive patients with LSCC treated with OPHL through a lateral cervical approach (LCA). Patients were evaluated using their Penetration Aspiration Scale score (liquid, semiliquid and solid) and Voice Handicap Index (VHI) at three different endpoints: 15 days (T1), 3 months (T2), and 6 months (T2) after surgery. Results: The functional outcomes of the LCA are stackable with that of the classical anterior cervical approach in terms of respiration, swallowing, and speech. One-way ANOVA was performed to evaluate the variances of PAS and VHI scores at the three different observation points. No statistically significant differences were observed between OPHL- PAS scores for liquid (p = 0.1) at the three different observation points. A statistically significant improvement was observed in the OPHL- PAS score for semisolids and solids (p < 0.00001) between T1 and T3 (p = 0.0001) and for solids between T2 and T3 (p < 0.00001). The improvement of VHI-10 was statistically significative (p < 0.00001) at the three different observation points (T1–T2 and T2–T3). Conclusion: The LCA is a potential approach for laryngeal surgery in selected cases. The preoperative staging and planning are of the utmost importance to ensure oncological radicality. The main advantage of this approach is the preservation of the healthy tissues surrounding the larynx and the functional and oncological outcomes are stackable with the classic anterior cervical approach.
format Online
Article
Text
id pubmed-9410219
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94102192022-08-26 Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach Colizza, Andrea Ralli, Massimo Di Stadio, Arianna Cambria, Francesca Zoccali, Federica Cialente, Fabrizio Angeletti, Diletta Greco, Antonio de Vincentiis, Marco J Clin Med Article Background: Open partial horizontal laryngectomies (OPHL) are one of the surgical techniques used for the conservative management of laryngeal cancers. The aims of this study are to analyze the oncological and functional results of a group of patients affected by laryngeal squamous cell carcinoma (LSCC) treated with OPHL, performed using a minimally invasive technique. Methods: This is a prospective case–control study. We enrolled 17 consecutive patients with LSCC treated with OPHL through a lateral cervical approach (LCA). Patients were evaluated using their Penetration Aspiration Scale score (liquid, semiliquid and solid) and Voice Handicap Index (VHI) at three different endpoints: 15 days (T1), 3 months (T2), and 6 months (T2) after surgery. Results: The functional outcomes of the LCA are stackable with that of the classical anterior cervical approach in terms of respiration, swallowing, and speech. One-way ANOVA was performed to evaluate the variances of PAS and VHI scores at the three different observation points. No statistically significant differences were observed between OPHL- PAS scores for liquid (p = 0.1) at the three different observation points. A statistically significant improvement was observed in the OPHL- PAS score for semisolids and solids (p < 0.00001) between T1 and T3 (p = 0.0001) and for solids between T2 and T3 (p < 0.00001). The improvement of VHI-10 was statistically significative (p < 0.00001) at the three different observation points (T1–T2 and T2–T3). Conclusion: The LCA is a potential approach for laryngeal surgery in selected cases. The preoperative staging and planning are of the utmost importance to ensure oncological radicality. The main advantage of this approach is the preservation of the healthy tissues surrounding the larynx and the functional and oncological outcomes are stackable with the classic anterior cervical approach. MDPI 2022-08-14 /pmc/articles/PMC9410219/ /pubmed/36012980 http://dx.doi.org/10.3390/jcm11164741 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Colizza, Andrea
Ralli, Massimo
Di Stadio, Arianna
Cambria, Francesca
Zoccali, Federica
Cialente, Fabrizio
Angeletti, Diletta
Greco, Antonio
de Vincentiis, Marco
Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
title Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
title_full Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
title_fullStr Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
title_full_unstemmed Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
title_short Outcomes of Laryngeal Cancer Surgery after Open Partial Horizontal Laryngectomies with Lateral Cervical Approach
title_sort outcomes of laryngeal cancer surgery after open partial horizontal laryngectomies with lateral cervical approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410219/
https://www.ncbi.nlm.nih.gov/pubmed/36012980
http://dx.doi.org/10.3390/jcm11164741
work_keys_str_mv AT colizzaandrea outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT rallimassimo outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT distadioarianna outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT cambriafrancesca outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT zoccalifederica outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT cialentefabrizio outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT angelettidiletta outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT grecoantonio outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach
AT devincentiismarco outcomesoflaryngealcancersurgeryafteropenpartialhorizontallaryngectomieswithlateralcervicalapproach