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Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK

Background: To evaluate the safety, efficacy, and predictability of laser-assisted in situ keratomileusis (LASIK) enhancement after primary LASIK and compare to Food and Drug Administration (FDA) criteria. Methods: Patients who underwent LASIK enhancement after primary LASIK between 2002 and 2019 we...

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Autores principales: Moshirfar, Majid, Basharat, Noor F., Bundogji, Nour, Ungricht, Emilie L., Darquea, Ines M., Conley, Matthew E., Ronquillo, Yasmyne C., Hoopes, Phillip C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410252/
https://www.ncbi.nlm.nih.gov/pubmed/36013070
http://dx.doi.org/10.3390/jcm11164832
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author Moshirfar, Majid
Basharat, Noor F.
Bundogji, Nour
Ungricht, Emilie L.
Darquea, Ines M.
Conley, Matthew E.
Ronquillo, Yasmyne C.
Hoopes, Phillip C.
author_facet Moshirfar, Majid
Basharat, Noor F.
Bundogji, Nour
Ungricht, Emilie L.
Darquea, Ines M.
Conley, Matthew E.
Ronquillo, Yasmyne C.
Hoopes, Phillip C.
author_sort Moshirfar, Majid
collection PubMed
description Background: To evaluate the safety, efficacy, and predictability of laser-assisted in situ keratomileusis (LASIK) enhancement after primary LASIK and compare to Food and Drug Administration (FDA) criteria. Methods: Patients who underwent LASIK enhancement after primary LASIK between 2002 and 2019 were compared to those who underwent LASIK without retreatment. Patient demographics, preoperative characteristics, visual outcomes, and postoperative complications were compared between groups. Epithelial ingrowth (EI) development was stratified based on duration between primary and secondary procedures. Results: We compared 901 eyes with LASIK enhancement to 1127 eyes without retreatment. Age, sex, surgical eye, sphere, cylinder, and spherical equivalent (SE) were significantly different between groups (p < 0.05). At 12 months post-enhancement, 86% of the eyes had an uncorrected distance visual acuity of 20/20 or better and 93% of eyes were within ±0.50 D of the target. Development of EI (6.1%) demonstrated an odds ratio of 16.3 in the long-term compared to the short-term (95% CI: 5.9 to 45.18; p < 0.0001). Conclusions: Older age at primary LASIK, female sex, right eye, and larger sphere, cylinder and SE were risk factors for enhancement. Risk of EI significantly increased when duration between primary and enhancement procedures exceeded five years. LASIK enhancements produce favorable outcomes and meet FDA benchmarks for safety, efficacy, and predictability.
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spelling pubmed-94102522022-08-26 Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK Moshirfar, Majid Basharat, Noor F. Bundogji, Nour Ungricht, Emilie L. Darquea, Ines M. Conley, Matthew E. Ronquillo, Yasmyne C. Hoopes, Phillip C. J Clin Med Article Background: To evaluate the safety, efficacy, and predictability of laser-assisted in situ keratomileusis (LASIK) enhancement after primary LASIK and compare to Food and Drug Administration (FDA) criteria. Methods: Patients who underwent LASIK enhancement after primary LASIK between 2002 and 2019 were compared to those who underwent LASIK without retreatment. Patient demographics, preoperative characteristics, visual outcomes, and postoperative complications were compared between groups. Epithelial ingrowth (EI) development was stratified based on duration between primary and secondary procedures. Results: We compared 901 eyes with LASIK enhancement to 1127 eyes without retreatment. Age, sex, surgical eye, sphere, cylinder, and spherical equivalent (SE) were significantly different between groups (p < 0.05). At 12 months post-enhancement, 86% of the eyes had an uncorrected distance visual acuity of 20/20 or better and 93% of eyes were within ±0.50 D of the target. Development of EI (6.1%) demonstrated an odds ratio of 16.3 in the long-term compared to the short-term (95% CI: 5.9 to 45.18; p < 0.0001). Conclusions: Older age at primary LASIK, female sex, right eye, and larger sphere, cylinder and SE were risk factors for enhancement. Risk of EI significantly increased when duration between primary and enhancement procedures exceeded five years. LASIK enhancements produce favorable outcomes and meet FDA benchmarks for safety, efficacy, and predictability. MDPI 2022-08-18 /pmc/articles/PMC9410252/ /pubmed/36013070 http://dx.doi.org/10.3390/jcm11164832 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moshirfar, Majid
Basharat, Noor F.
Bundogji, Nour
Ungricht, Emilie L.
Darquea, Ines M.
Conley, Matthew E.
Ronquillo, Yasmyne C.
Hoopes, Phillip C.
Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK
title Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK
title_full Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK
title_fullStr Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK
title_full_unstemmed Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK
title_short Laser-Assisted In Situ Keratomileusis (LASIK) Enhancement for Residual Refractive Error after Primary LASIK
title_sort laser-assisted in situ keratomileusis (lasik) enhancement for residual refractive error after primary lasik
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410252/
https://www.ncbi.nlm.nih.gov/pubmed/36013070
http://dx.doi.org/10.3390/jcm11164832
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