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Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells

There are two main enzymes that convert tryptophan (Trp) to kynurenine (Kyn): tryptophan-2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO). Kyn accumulation can promote immunosuppression in certain cancers. In this study, we investigated Trp degradation to Kyn by IDO and TDO in primary hum...

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Detalles Bibliográficos
Autores principales:	Oweira, Hani, Lahdou, Imad, Mehrle, Stefan, Khajeh, Elias, Nikbakhsh, Rajan, Ghamarnejad, Omid, Terness, Peter, Reißfelder, Christoph, Sadeghi, Mahmoud, Ramouz, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410271/ https://www.ncbi.nlm.nih.gov/pubmed/36013032 http://dx.doi.org/10.3390/jcm11164794

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