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The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients

Usually, the administration of drugs by feeding tube in dysphagic patients involves handling of marketing licenses outside their term, due to the lack of suitable formulations. This circumstance has put health professionals in the dilemma of choosing the formulation whose manipulation possibly does...

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Autores principales: Zuccari, Guendalina, Macis, Sara, Alfei, Silvana, Marchitto, Leonardo, Russo, Eleonora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410388/
https://www.ncbi.nlm.nih.gov/pubmed/36013259
http://dx.doi.org/10.3390/jpm12081307
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author Zuccari, Guendalina
Macis, Sara
Alfei, Silvana
Marchitto, Leonardo
Russo, Eleonora
author_facet Zuccari, Guendalina
Macis, Sara
Alfei, Silvana
Marchitto, Leonardo
Russo, Eleonora
author_sort Zuccari, Guendalina
collection PubMed
description Usually, the administration of drugs by feeding tube in dysphagic patients involves handling of marketing licenses outside their term, due to the lack of suitable formulations. This circumstance has put health professionals in the dilemma of choosing the formulation whose manipulation possibly does not alter the effectiveness of the drug. In this regard, a practical guide providing indications on the prescription, handling, and administration of drugs through enteral feeding tube could be of paramount utility. For this purpose, we have considered the 1047 solid oral pharmaceutical forms included in the formulary of San Paolo Hospital (Savona, Italy). From our analysis, it emerges that 95% of medicinal products are worryingly used off-label and 40% have to be managed by the hospital pharmacists without having suitable indications by either the manufacturers or by literature studies. To fill this gap, we have compiled a detailed table containing missing indications derived from pharmacist expertise and evidence-based practices, with the aim that the sharing of our procedures will contribute to make uniform pharmacological therapies from one hospital to another. This study will allow doctors to have easy access to information on drugs that can be prescribed and nurses to become familiar only with the pharmaceutical forms that can be administered.
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spelling pubmed-94103882022-08-26 The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients Zuccari, Guendalina Macis, Sara Alfei, Silvana Marchitto, Leonardo Russo, Eleonora J Pers Med Article Usually, the administration of drugs by feeding tube in dysphagic patients involves handling of marketing licenses outside their term, due to the lack of suitable formulations. This circumstance has put health professionals in the dilemma of choosing the formulation whose manipulation possibly does not alter the effectiveness of the drug. In this regard, a practical guide providing indications on the prescription, handling, and administration of drugs through enteral feeding tube could be of paramount utility. For this purpose, we have considered the 1047 solid oral pharmaceutical forms included in the formulary of San Paolo Hospital (Savona, Italy). From our analysis, it emerges that 95% of medicinal products are worryingly used off-label and 40% have to be managed by the hospital pharmacists without having suitable indications by either the manufacturers or by literature studies. To fill this gap, we have compiled a detailed table containing missing indications derived from pharmacist expertise and evidence-based practices, with the aim that the sharing of our procedures will contribute to make uniform pharmacological therapies from one hospital to another. This study will allow doctors to have easy access to information on drugs that can be prescribed and nurses to become familiar only with the pharmaceutical forms that can be administered. MDPI 2022-08-12 /pmc/articles/PMC9410388/ /pubmed/36013259 http://dx.doi.org/10.3390/jpm12081307 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zuccari, Guendalina
Macis, Sara
Alfei, Silvana
Marchitto, Leonardo
Russo, Eleonora
The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients
title The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients
title_full The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients
title_fullStr The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients
title_full_unstemmed The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients
title_short The Role of the Pharmacist in Selecting the Best Choice of Medication Formulation in Dysphagic Patients
title_sort role of the pharmacist in selecting the best choice of medication formulation in dysphagic patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410388/
https://www.ncbi.nlm.nih.gov/pubmed/36013259
http://dx.doi.org/10.3390/jpm12081307
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