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Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis

Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies have described a conflicting association between the use of PPIs during pregnancy and preeclampsia risk. This study aimed to evaluate the associa...

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Autores principales: Hussain, Salman, Singh, Ambrish, Antony, Benny, Klugarová, Jitka, Murad, M. Hassan, Jayraj, Aarthi S., Langaufová, Alena, Klugar, Miloslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410414/
https://www.ncbi.nlm.nih.gov/pubmed/36012913
http://dx.doi.org/10.3390/jcm11164675
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author Hussain, Salman
Singh, Ambrish
Antony, Benny
Klugarová, Jitka
Murad, M. Hassan
Jayraj, Aarthi S.
Langaufová, Alena
Klugar, Miloslav
author_facet Hussain, Salman
Singh, Ambrish
Antony, Benny
Klugarová, Jitka
Murad, M. Hassan
Jayraj, Aarthi S.
Langaufová, Alena
Klugar, Miloslav
author_sort Hussain, Salman
collection PubMed
description Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies have described a conflicting association between the use of PPIs during pregnancy and preeclampsia risk. This study aimed to evaluate the association between PPI use and the risk of preeclampsia. We searched databases, including MEDLINE, Embase, Scopus, Web of Science Core Collection, Emcare, CINAHL, and the relevant grey literature from inception until 13 September 2021. Studies reporting the preeclampsia risk with the use of PPIs were eligible for inclusion. Literature screening, data extraction, and the risk of bias assessment were performed independently by two investigators. Random-effect meta-analysis was performed to generate relative risks (RR) and 95% confidence intervals (CI). The risk of preeclampsia and preterm preeclampsia among women receiving PPIs during pregnancy were the primary outcomes of interest. This meta-analysis comprised three studies involving 4,877,565 pregnant women, of whom 119,017 were PPI users. The included studies were judged to have a low risk of bias. The risk of preeclampsia among pregnant women who received PPIs anytime during pregnancy was significantly increased (RR 1.27 (95% CI: 1.23–1.31)), although the increase was trivial in absolute terms (2 per 1000). The subgroup analysis revealed that the risk was increased in each of the three trimesters. The risk of preterm preeclampsia among pregnant women receiving PPIs anytime during pregnancy was not significantly increased (RR 1.04 (95% CI: 0.70–1.55)). The certainty evaluated by GRADE in these estimates was low. PPI use may be associated with a trivial increase in the risk of preeclampsia in pregnant women. There is no evidence supporting that PPI use decreases the risk of preeclampsia or preterm preeclampsia.
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spelling pubmed-94104142022-08-26 Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis Hussain, Salman Singh, Ambrish Antony, Benny Klugarová, Jitka Murad, M. Hassan Jayraj, Aarthi S. Langaufová, Alena Klugar, Miloslav J Clin Med Article Evidence from preclinical studies suggests a preventive effect of proton pump inhibitors (PPIs) in preeclampsia. Recently, several epidemiological studies have described a conflicting association between the use of PPIs during pregnancy and preeclampsia risk. This study aimed to evaluate the association between PPI use and the risk of preeclampsia. We searched databases, including MEDLINE, Embase, Scopus, Web of Science Core Collection, Emcare, CINAHL, and the relevant grey literature from inception until 13 September 2021. Studies reporting the preeclampsia risk with the use of PPIs were eligible for inclusion. Literature screening, data extraction, and the risk of bias assessment were performed independently by two investigators. Random-effect meta-analysis was performed to generate relative risks (RR) and 95% confidence intervals (CI). The risk of preeclampsia and preterm preeclampsia among women receiving PPIs during pregnancy were the primary outcomes of interest. This meta-analysis comprised three studies involving 4,877,565 pregnant women, of whom 119,017 were PPI users. The included studies were judged to have a low risk of bias. The risk of preeclampsia among pregnant women who received PPIs anytime during pregnancy was significantly increased (RR 1.27 (95% CI: 1.23–1.31)), although the increase was trivial in absolute terms (2 per 1000). The subgroup analysis revealed that the risk was increased in each of the three trimesters. The risk of preterm preeclampsia among pregnant women receiving PPIs anytime during pregnancy was not significantly increased (RR 1.04 (95% CI: 0.70–1.55)). The certainty evaluated by GRADE in these estimates was low. PPI use may be associated with a trivial increase in the risk of preeclampsia in pregnant women. There is no evidence supporting that PPI use decreases the risk of preeclampsia or preterm preeclampsia. MDPI 2022-08-10 /pmc/articles/PMC9410414/ /pubmed/36012913 http://dx.doi.org/10.3390/jcm11164675 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hussain, Salman
Singh, Ambrish
Antony, Benny
Klugarová, Jitka
Murad, M. Hassan
Jayraj, Aarthi S.
Langaufová, Alena
Klugar, Miloslav
Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
title Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
title_full Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
title_fullStr Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
title_full_unstemmed Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
title_short Proton Pump Inhibitors Use and Risk of Preeclampsia: A Meta-Analysis
title_sort proton pump inhibitors use and risk of preeclampsia: a meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410414/
https://www.ncbi.nlm.nih.gov/pubmed/36012913
http://dx.doi.org/10.3390/jcm11164675
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