Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits Ca(V)1.2 and Stimulates K(Ca)1.1 Channels

Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareolide, this molecule was selected as a scaffold to...

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Detalles Bibliográficos
Autores principales: Carullo, Gabriele, Saponara, Simona, Ahmed, Amer, Gorelli, Beatrice, Mazzotta, Sarah, Trezza, Alfonso, Gianibbi, Beatrice, Campiani, Giuseppe, Fusi, Fabio, Aiello, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410420/
https://www.ncbi.nlm.nih.gov/pubmed/36005518
http://dx.doi.org/10.3390/md20080515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410420/
https://www.ncbi.nlm.nih.gov/pubmed/36005518
http://dx.doi.org/10.3390/md20080515

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