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Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation

We evaluated the 3-year clinical outcomes of early invasive (EI) and delayed invasive (DI) strategies in older and younger adults with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing successful new-generation drug-eluting stent (DES) implantation to reflect current real-world prac...

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Autores principales: Kim, Yong Hoon, Her, Ae-Young, Rha, Seung-Woon, Choi, Cheol Ung, Choi, Byoung Geol, Kim, Ji Bak, Park, Soohyung, Kang, Dong Oh, Park, Ji Young, Park, Sang-Ho, Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410439/
https://www.ncbi.nlm.nih.gov/pubmed/36013019
http://dx.doi.org/10.3390/jcm11164780
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author Kim, Yong Hoon
Her, Ae-Young
Rha, Seung-Woon
Choi, Cheol Ung
Choi, Byoung Geol
Kim, Ji Bak
Park, Soohyung
Kang, Dong Oh
Park, Ji Young
Park, Sang-Ho
Jeong, Myung Ho
author_facet Kim, Yong Hoon
Her, Ae-Young
Rha, Seung-Woon
Choi, Cheol Ung
Choi, Byoung Geol
Kim, Ji Bak
Park, Soohyung
Kang, Dong Oh
Park, Ji Young
Park, Sang-Ho
Jeong, Myung Ho
author_sort Kim, Yong Hoon
collection PubMed
description We evaluated the 3-year clinical outcomes of early invasive (EI) and delayed invasive (DI) strategies in older and younger adults with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing successful new-generation drug-eluting stent (DES) implantation to reflect current real-world practice. Overall, 4513 patients with NSTEMI were recruited from the Korea Acute Myocardial Infarction Registry-National Institute of Health and divided into two groups according to age: group A (age ≥ 65 years, n = 2253) and group B (age < 65 years, n = 2260). These two groups were further divided into two subgroups: group EI (A1 and B1) and DI (A2 and B2). The primary clinical outcome was the occurrence of major adverse cardiac and cerebrovascular events (MACCEs), defined as all-cause death, recurrent MI (re-MI), any repeat coronary revascularization, or stroke. The secondary clinical outcome was definite or probable stent thrombosis (ST). In both groups A and B, after multivariable-adjusted and propensity score-adjusted analyses, MACCE (group A, p = 0.137 and p = 0.255, respectively; group B, p = 0.171 and p = 0.135, respectively), all-cause death, cardiac death (CD), non-CD, re-MI, any repeat revascularization, stroke, and ST rates were similar between the EI and DI groups. When including only those with complex lesions, the primary and secondary clinical outcomes were not significantly different between the EI and DI groups. In the era of new-generation DESs, major clinical outcomes were not significantly different between the EI and DI strategies in both older and younger adults with NSTEMI.
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spelling pubmed-94104392022-08-26 Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation Kim, Yong Hoon Her, Ae-Young Rha, Seung-Woon Choi, Cheol Ung Choi, Byoung Geol Kim, Ji Bak Park, Soohyung Kang, Dong Oh Park, Ji Young Park, Sang-Ho Jeong, Myung Ho J Clin Med Article We evaluated the 3-year clinical outcomes of early invasive (EI) and delayed invasive (DI) strategies in older and younger adults with non-ST-segment elevation myocardial infarction (NSTEMI) undergoing successful new-generation drug-eluting stent (DES) implantation to reflect current real-world practice. Overall, 4513 patients with NSTEMI were recruited from the Korea Acute Myocardial Infarction Registry-National Institute of Health and divided into two groups according to age: group A (age ≥ 65 years, n = 2253) and group B (age < 65 years, n = 2260). These two groups were further divided into two subgroups: group EI (A1 and B1) and DI (A2 and B2). The primary clinical outcome was the occurrence of major adverse cardiac and cerebrovascular events (MACCEs), defined as all-cause death, recurrent MI (re-MI), any repeat coronary revascularization, or stroke. The secondary clinical outcome was definite or probable stent thrombosis (ST). In both groups A and B, after multivariable-adjusted and propensity score-adjusted analyses, MACCE (group A, p = 0.137 and p = 0.255, respectively; group B, p = 0.171 and p = 0.135, respectively), all-cause death, cardiac death (CD), non-CD, re-MI, any repeat revascularization, stroke, and ST rates were similar between the EI and DI groups. When including only those with complex lesions, the primary and secondary clinical outcomes were not significantly different between the EI and DI groups. In the era of new-generation DESs, major clinical outcomes were not significantly different between the EI and DI strategies in both older and younger adults with NSTEMI. MDPI 2022-08-16 /pmc/articles/PMC9410439/ /pubmed/36013019 http://dx.doi.org/10.3390/jcm11164780 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Yong Hoon
Her, Ae-Young
Rha, Seung-Woon
Choi, Cheol Ung
Choi, Byoung Geol
Kim, Ji Bak
Park, Soohyung
Kang, Dong Oh
Park, Ji Young
Park, Sang-Ho
Jeong, Myung Ho
Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_full Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_fullStr Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_full_unstemmed Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_short Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_sort comparison of 3-year outcomes between early and delayed invasive strategies in older and younger adults with non-st-segment elevation myocardial infarction undergoing new-generation drug-eluting stent implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410439/
https://www.ncbi.nlm.nih.gov/pubmed/36013019
http://dx.doi.org/10.3390/jcm11164780
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