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The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease

The current minireview aims to assess the implications of epicardial fat secretory function in the development of coronary artery disease. The epicardial adipose tissue (EAT) is a visceral fat depot that has been described as a cardiovascular risk factor. In addition to its mechanical protection rol...

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Autores principales: Braescu, Laurentiu, Gaspar, Marinica, Buriman, Darius, Aburel, Oana Maria, Merce, Adrian-Petru, Bratosin, Felix, Aleksandrovich, Klokov Sergei, Alambaram, Satish, Mornos, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410442/
https://www.ncbi.nlm.nih.gov/pubmed/36012956
http://dx.doi.org/10.3390/jcm11164718
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author Braescu, Laurentiu
Gaspar, Marinica
Buriman, Darius
Aburel, Oana Maria
Merce, Adrian-Petru
Bratosin, Felix
Aleksandrovich, Klokov Sergei
Alambaram, Satish
Mornos, Cristian
author_facet Braescu, Laurentiu
Gaspar, Marinica
Buriman, Darius
Aburel, Oana Maria
Merce, Adrian-Petru
Bratosin, Felix
Aleksandrovich, Klokov Sergei
Alambaram, Satish
Mornos, Cristian
author_sort Braescu, Laurentiu
collection PubMed
description The current minireview aims to assess the implications of epicardial fat secretory function in the development of coronary artery disease. The epicardial adipose tissue (EAT) is a visceral fat depot that has been described as a cardiovascular risk factor. In addition to its mechanical protection role and physiological secretory function, it seems that various secretion products of the epicardial fat are responsible for metabolic disturbances at the level of the cardiac muscle when in association with pre-existing pathological conditions, such as metabolic syndrome. There is a pathological reduction in sarcomere shortening, abnormal cytosolic Ca(2+) fluxes, reduced expression of sarcoplasmic endoplasmic reticulum ATPase 2a and decreased insulin-mediated Akt-Ser473-phosphorylation in association with abnormal levels of epicardial fat tissue. Activin A, angiopoietin-2, and CD14-positive monocytes selectively accumulate in the diseased myocardium, resulting in reduced cardiomyocyte contractile function. At the same time, it is believed that these alterations in secretory products directly decrease the myocyte function via molecular changes, thus contributing to the development of coronary disease when certain comorbidities are associated.
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spelling pubmed-94104422022-08-26 The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease Braescu, Laurentiu Gaspar, Marinica Buriman, Darius Aburel, Oana Maria Merce, Adrian-Petru Bratosin, Felix Aleksandrovich, Klokov Sergei Alambaram, Satish Mornos, Cristian J Clin Med Review The current minireview aims to assess the implications of epicardial fat secretory function in the development of coronary artery disease. The epicardial adipose tissue (EAT) is a visceral fat depot that has been described as a cardiovascular risk factor. In addition to its mechanical protection role and physiological secretory function, it seems that various secretion products of the epicardial fat are responsible for metabolic disturbances at the level of the cardiac muscle when in association with pre-existing pathological conditions, such as metabolic syndrome. There is a pathological reduction in sarcomere shortening, abnormal cytosolic Ca(2+) fluxes, reduced expression of sarcoplasmic endoplasmic reticulum ATPase 2a and decreased insulin-mediated Akt-Ser473-phosphorylation in association with abnormal levels of epicardial fat tissue. Activin A, angiopoietin-2, and CD14-positive monocytes selectively accumulate in the diseased myocardium, resulting in reduced cardiomyocyte contractile function. At the same time, it is believed that these alterations in secretory products directly decrease the myocyte function via molecular changes, thus contributing to the development of coronary disease when certain comorbidities are associated. MDPI 2022-08-12 /pmc/articles/PMC9410442/ /pubmed/36012956 http://dx.doi.org/10.3390/jcm11164718 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Braescu, Laurentiu
Gaspar, Marinica
Buriman, Darius
Aburel, Oana Maria
Merce, Adrian-Petru
Bratosin, Felix
Aleksandrovich, Klokov Sergei
Alambaram, Satish
Mornos, Cristian
The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease
title The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease
title_full The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease
title_fullStr The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease
title_full_unstemmed The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease
title_short The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease
title_sort role and implications of epicardial fat in coronary atherosclerotic disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410442/
https://www.ncbi.nlm.nih.gov/pubmed/36012956
http://dx.doi.org/10.3390/jcm11164718
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