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Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients

Given the increasing prevalence of chronic kidney disease (CKD) and its impact on health care, it is important to better understand the multiple factors influencing health-related quality of life (HRQOL), particularly since they have been shown to affect CKD outcomes. Determinants of HRQOL as measur...

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Autores principales: Wirkner, Janine, Scheuch, Matthias, Dabers, Thomas, Freiin von Rheinbaben, Sabrina, Fiene, Beate, Aymanns, Simone, Endlich, Karlhans, Endlich, Nicole, Lendeckel, Uwe, Rettig, Rainer, Grabe, Hans Jörgen, Stracke, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410519/
https://www.ncbi.nlm.nih.gov/pubmed/36012909
http://dx.doi.org/10.3390/jcm11164671
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author Wirkner, Janine
Scheuch, Matthias
Dabers, Thomas
Freiin von Rheinbaben, Sabrina
Fiene, Beate
Aymanns, Simone
Endlich, Karlhans
Endlich, Nicole
Lendeckel, Uwe
Rettig, Rainer
Grabe, Hans Jörgen
Stracke, Sylvia
author_facet Wirkner, Janine
Scheuch, Matthias
Dabers, Thomas
Freiin von Rheinbaben, Sabrina
Fiene, Beate
Aymanns, Simone
Endlich, Karlhans
Endlich, Nicole
Lendeckel, Uwe
Rettig, Rainer
Grabe, Hans Jörgen
Stracke, Sylvia
author_sort Wirkner, Janine
collection PubMed
description Given the increasing prevalence of chronic kidney disease (CKD) and its impact on health care, it is important to better understand the multiple factors influencing health-related quality of life (HRQOL), particularly since they have been shown to affect CKD outcomes. Determinants of HRQOL as measured by the validated Kidney Disease Quality of Life questionnaire (KDQOL) and the Patient Health Questionnaire depression screener (PHQ-9) were assessed in a routine CKD patient sample, the Greifswald Approach to Individualized Medicine (GANI_MED) renal cohort (N = 160), including a wide range of self-reported data, sociodemographic and laboratory measures. Compared to the general population, CKD patients had lower HRQOL indices. Dialysis was associated with (1) low levels of physical functioning, (2) increased impairments by symptoms and problems, and (3) more effects and burden of kidney disease. HRQOL is seriously affected in CKD patients. However, impairments were found irrespective of eGFR decline and albuminuria. Rather, the comorbid conditions of depression and diabetes predicted a lower HRQOL (physical component score). Further studies should address whether recognizing and treating depression may not only improve HRQOL but also promote survival and lower hospitalization rates of CKD patients.
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spelling pubmed-94105192022-08-26 Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients Wirkner, Janine Scheuch, Matthias Dabers, Thomas Freiin von Rheinbaben, Sabrina Fiene, Beate Aymanns, Simone Endlich, Karlhans Endlich, Nicole Lendeckel, Uwe Rettig, Rainer Grabe, Hans Jörgen Stracke, Sylvia J Clin Med Article Given the increasing prevalence of chronic kidney disease (CKD) and its impact on health care, it is important to better understand the multiple factors influencing health-related quality of life (HRQOL), particularly since they have been shown to affect CKD outcomes. Determinants of HRQOL as measured by the validated Kidney Disease Quality of Life questionnaire (KDQOL) and the Patient Health Questionnaire depression screener (PHQ-9) were assessed in a routine CKD patient sample, the Greifswald Approach to Individualized Medicine (GANI_MED) renal cohort (N = 160), including a wide range of self-reported data, sociodemographic and laboratory measures. Compared to the general population, CKD patients had lower HRQOL indices. Dialysis was associated with (1) low levels of physical functioning, (2) increased impairments by symptoms and problems, and (3) more effects and burden of kidney disease. HRQOL is seriously affected in CKD patients. However, impairments were found irrespective of eGFR decline and albuminuria. Rather, the comorbid conditions of depression and diabetes predicted a lower HRQOL (physical component score). Further studies should address whether recognizing and treating depression may not only improve HRQOL but also promote survival and lower hospitalization rates of CKD patients. MDPI 2022-08-10 /pmc/articles/PMC9410519/ /pubmed/36012909 http://dx.doi.org/10.3390/jcm11164671 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wirkner, Janine
Scheuch, Matthias
Dabers, Thomas
Freiin von Rheinbaben, Sabrina
Fiene, Beate
Aymanns, Simone
Endlich, Karlhans
Endlich, Nicole
Lendeckel, Uwe
Rettig, Rainer
Grabe, Hans Jörgen
Stracke, Sylvia
Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
title Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
title_full Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
title_fullStr Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
title_full_unstemmed Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
title_short Comorbid Depression and Diabetes Are Associated with Impaired Health-Related Quality of Life in Chronic Kidney Disease Patients
title_sort comorbid depression and diabetes are associated with impaired health-related quality of life in chronic kidney disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410519/
https://www.ncbi.nlm.nih.gov/pubmed/36012909
http://dx.doi.org/10.3390/jcm11164671
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