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The Evolution of a Large Biobank at Mass General Brigham

The Mass General Brigham Biobank (formerly Partners HealthCare Biobank) is a large repository of biospecimens and data linked to extensive electronic health record data and survey data. Its objective is to support and enable translational research focused on genomic, environmental, biomarker and fam...

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Autores principales: Boutin, Natalie T., Schecter, Samantha B., Perez, Emma F., Tchamitchian, Natasha S., Cerretani, Xander R., Gainer, Vivian S., Lebo, Matthew S., Mahanta, Lisa M., Karlson, Elizabeth W., Smoller, Jordan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410531/
https://www.ncbi.nlm.nih.gov/pubmed/36013271
http://dx.doi.org/10.3390/jpm12081323
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author Boutin, Natalie T.
Schecter, Samantha B.
Perez, Emma F.
Tchamitchian, Natasha S.
Cerretani, Xander R.
Gainer, Vivian S.
Lebo, Matthew S.
Mahanta, Lisa M.
Karlson, Elizabeth W.
Smoller, Jordan W.
author_facet Boutin, Natalie T.
Schecter, Samantha B.
Perez, Emma F.
Tchamitchian, Natasha S.
Cerretani, Xander R.
Gainer, Vivian S.
Lebo, Matthew S.
Mahanta, Lisa M.
Karlson, Elizabeth W.
Smoller, Jordan W.
author_sort Boutin, Natalie T.
collection PubMed
description The Mass General Brigham Biobank (formerly Partners HealthCare Biobank) is a large repository of biospecimens and data linked to extensive electronic health record data and survey data. Its objective is to support and enable translational research focused on genomic, environmental, biomarker and family history associations with disease phenotypes. The Biobank has enrolled more than 135,000 participants, generated genomic data on more than 65,000 of its participants, distributed approximately 153,000 biospecimens, and served close to 450 institutional studies with biospecimens or data. Although the Biobank has been successful, based on some measures of output, this has required substantial institutional investment. In addition, several challenges are ongoing, including: (1) developing a sustainable cost model that doesn’t rely as heavily on institutional funding; (2) integrating Biobank operations into clinical workflows; and (3) building a research resource that is diverse and promotes equity in research. Here, we describe the evolution of the Biobank and highlight key lessons learned that may inform other efforts to build biobanking efforts in health system contexts.
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spelling pubmed-94105312022-08-26 The Evolution of a Large Biobank at Mass General Brigham Boutin, Natalie T. Schecter, Samantha B. Perez, Emma F. Tchamitchian, Natasha S. Cerretani, Xander R. Gainer, Vivian S. Lebo, Matthew S. Mahanta, Lisa M. Karlson, Elizabeth W. Smoller, Jordan W. J Pers Med Article The Mass General Brigham Biobank (formerly Partners HealthCare Biobank) is a large repository of biospecimens and data linked to extensive electronic health record data and survey data. Its objective is to support and enable translational research focused on genomic, environmental, biomarker and family history associations with disease phenotypes. The Biobank has enrolled more than 135,000 participants, generated genomic data on more than 65,000 of its participants, distributed approximately 153,000 biospecimens, and served close to 450 institutional studies with biospecimens or data. Although the Biobank has been successful, based on some measures of output, this has required substantial institutional investment. In addition, several challenges are ongoing, including: (1) developing a sustainable cost model that doesn’t rely as heavily on institutional funding; (2) integrating Biobank operations into clinical workflows; and (3) building a research resource that is diverse and promotes equity in research. Here, we describe the evolution of the Biobank and highlight key lessons learned that may inform other efforts to build biobanking efforts in health system contexts. MDPI 2022-08-17 /pmc/articles/PMC9410531/ /pubmed/36013271 http://dx.doi.org/10.3390/jpm12081323 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boutin, Natalie T.
Schecter, Samantha B.
Perez, Emma F.
Tchamitchian, Natasha S.
Cerretani, Xander R.
Gainer, Vivian S.
Lebo, Matthew S.
Mahanta, Lisa M.
Karlson, Elizabeth W.
Smoller, Jordan W.
The Evolution of a Large Biobank at Mass General Brigham
title The Evolution of a Large Biobank at Mass General Brigham
title_full The Evolution of a Large Biobank at Mass General Brigham
title_fullStr The Evolution of a Large Biobank at Mass General Brigham
title_full_unstemmed The Evolution of a Large Biobank at Mass General Brigham
title_short The Evolution of a Large Biobank at Mass General Brigham
title_sort evolution of a large biobank at mass general brigham
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410531/
https://www.ncbi.nlm.nih.gov/pubmed/36013271
http://dx.doi.org/10.3390/jpm12081323
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