Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane

Lassa virus (LASV) cell entry is mediated by the interaction of the virus glycoprotein complex (GPC) with alpha-dystroglycan at the cell surface followed by binding to LAMP1 in late endosomes. However, LAMP1 is not absolutely required for LASV fusion, as this virus can infect LAMP1-deficient cells....

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, You, Carlos de la Torre, Juan, Melikyan, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410554/
https://www.ncbi.nlm.nih.gov/pubmed/35969633
http://dx.doi.org/10.1371/journal.ppat.1010625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410554/
https://www.ncbi.nlm.nih.gov/pubmed/35969633
http://dx.doi.org/10.1371/journal.ppat.1010625

Ejemplares similares