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Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study

Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced microecosystem is essential to human health. Animal studies...

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Autores principales: Zhang, Xiyu, He, Yuchi, Xie, Ziyan, Peng, Sihan, Xie, Chunguang, Wang, Heting, Liu, Lu, Kang, Jian, Yuan, Haipo, Liu, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410575/
https://www.ncbi.nlm.nih.gov/pubmed/36042641
http://dx.doi.org/10.1097/MD.0000000000030215
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author Zhang, Xiyu
He, Yuchi
Xie, Ziyan
Peng, Sihan
Xie, Chunguang
Wang, Heting
Liu, Lu
Kang, Jian
Yuan, Haipo
Liu, Ya
author_facet Zhang, Xiyu
He, Yuchi
Xie, Ziyan
Peng, Sihan
Xie, Chunguang
Wang, Heting
Liu, Lu
Kang, Jian
Yuan, Haipo
Liu, Ya
author_sort Zhang, Xiyu
collection PubMed
description Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced microecosystem is essential to human health. Animal studies have shown that long-term exposure to microplastics can change the characteristics of the microbiota in organisms, leading to respiratory, digestive, immune, and other system diseases. However, the current research on microplastics is still dominated by animal experiments, and the impact of microplastics on human health is still in its infancy, so relevant research is urgently needed. Twenty participants with high exposure to microplastics will come from a plastic factory in Chengdu, China. We will perform 16S rDNA sequencing on participants’ nasal secretions, and stool samples. Additionally, we will perform 8700 LDIR laser infrared imaging of environmental soil and air filter membrane samples. For comparison, we will also collect samples from 20 volunteers from an area with good environmental quality in Chengdu. To find out the potential predictors and to access the difference between the groups, statistical analysis will be performed in the end. The study will be the first observational cross-sectional study focusing on the effects of microplastics on nasal and gut microbiota of high-exposure population. The study is expected to provide reliable evidence to fill the gaps in the impact of microplastics on human health.
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spelling pubmed-94105752022-08-26 Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study Zhang, Xiyu He, Yuchi Xie, Ziyan Peng, Sihan Xie, Chunguang Wang, Heting Liu, Lu Kang, Jian Yuan, Haipo Liu, Ya Medicine (Baltimore) Research Article Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced microecosystem is essential to human health. Animal studies have shown that long-term exposure to microplastics can change the characteristics of the microbiota in organisms, leading to respiratory, digestive, immune, and other system diseases. However, the current research on microplastics is still dominated by animal experiments, and the impact of microplastics on human health is still in its infancy, so relevant research is urgently needed. Twenty participants with high exposure to microplastics will come from a plastic factory in Chengdu, China. We will perform 16S rDNA sequencing on participants’ nasal secretions, and stool samples. Additionally, we will perform 8700 LDIR laser infrared imaging of environmental soil and air filter membrane samples. For comparison, we will also collect samples from 20 volunteers from an area with good environmental quality in Chengdu. To find out the potential predictors and to access the difference between the groups, statistical analysis will be performed in the end. The study will be the first observational cross-sectional study focusing on the effects of microplastics on nasal and gut microbiota of high-exposure population. The study is expected to provide reliable evidence to fill the gaps in the impact of microplastics on human health. Lippincott Williams & Wilkins 2022-08-26 /pmc/articles/PMC9410575/ /pubmed/36042641 http://dx.doi.org/10.1097/MD.0000000000030215 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Xiyu
He, Yuchi
Xie, Ziyan
Peng, Sihan
Xie, Chunguang
Wang, Heting
Liu, Lu
Kang, Jian
Yuan, Haipo
Liu, Ya
Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
title Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
title_full Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
title_fullStr Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
title_full_unstemmed Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
title_short Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
title_sort effect of microplastics on nasal and gut microbiota of high-exposure population: protocol for an observational cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410575/
https://www.ncbi.nlm.nih.gov/pubmed/36042641
http://dx.doi.org/10.1097/MD.0000000000030215
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