Cargando…
Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study
Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced microecosystem is essential to human health. Animal studies...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410575/ https://www.ncbi.nlm.nih.gov/pubmed/36042641 http://dx.doi.org/10.1097/MD.0000000000030215 |
_version_ | 1784775125611053056 |
---|---|
author | Zhang, Xiyu He, Yuchi Xie, Ziyan Peng, Sihan Xie, Chunguang Wang, Heting Liu, Lu Kang, Jian Yuan, Haipo Liu, Ya |
author_facet | Zhang, Xiyu He, Yuchi Xie, Ziyan Peng, Sihan Xie, Chunguang Wang, Heting Liu, Lu Kang, Jian Yuan, Haipo Liu, Ya |
author_sort | Zhang, Xiyu |
collection | PubMed |
description | Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced microecosystem is essential to human health. Animal studies have shown that long-term exposure to microplastics can change the characteristics of the microbiota in organisms, leading to respiratory, digestive, immune, and other system diseases. However, the current research on microplastics is still dominated by animal experiments, and the impact of microplastics on human health is still in its infancy, so relevant research is urgently needed. Twenty participants with high exposure to microplastics will come from a plastic factory in Chengdu, China. We will perform 16S rDNA sequencing on participants’ nasal secretions, and stool samples. Additionally, we will perform 8700 LDIR laser infrared imaging of environmental soil and air filter membrane samples. For comparison, we will also collect samples from 20 volunteers from an area with good environmental quality in Chengdu. To find out the potential predictors and to access the difference between the groups, statistical analysis will be performed in the end. The study will be the first observational cross-sectional study focusing on the effects of microplastics on nasal and gut microbiota of high-exposure population. The study is expected to provide reliable evidence to fill the gaps in the impact of microplastics on human health. |
format | Online Article Text |
id | pubmed-9410575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-94105752022-08-26 Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study Zhang, Xiyu He, Yuchi Xie, Ziyan Peng, Sihan Xie, Chunguang Wang, Heting Liu, Lu Kang, Jian Yuan, Haipo Liu, Ya Medicine (Baltimore) Research Article Microplastics have the characteristics of small size, high specific area, strong ability to adsorb pollutants, and difficult to degrade. They have become a major global environmental problem that humans urgently need to address. A balanced microecosystem is essential to human health. Animal studies have shown that long-term exposure to microplastics can change the characteristics of the microbiota in organisms, leading to respiratory, digestive, immune, and other system diseases. However, the current research on microplastics is still dominated by animal experiments, and the impact of microplastics on human health is still in its infancy, so relevant research is urgently needed. Twenty participants with high exposure to microplastics will come from a plastic factory in Chengdu, China. We will perform 16S rDNA sequencing on participants’ nasal secretions, and stool samples. Additionally, we will perform 8700 LDIR laser infrared imaging of environmental soil and air filter membrane samples. For comparison, we will also collect samples from 20 volunteers from an area with good environmental quality in Chengdu. To find out the potential predictors and to access the difference between the groups, statistical analysis will be performed in the end. The study will be the first observational cross-sectional study focusing on the effects of microplastics on nasal and gut microbiota of high-exposure population. The study is expected to provide reliable evidence to fill the gaps in the impact of microplastics on human health. Lippincott Williams & Wilkins 2022-08-26 /pmc/articles/PMC9410575/ /pubmed/36042641 http://dx.doi.org/10.1097/MD.0000000000030215 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Xiyu He, Yuchi Xie, Ziyan Peng, Sihan Xie, Chunguang Wang, Heting Liu, Lu Kang, Jian Yuan, Haipo Liu, Ya Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study |
title | Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study |
title_full | Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study |
title_fullStr | Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study |
title_full_unstemmed | Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study |
title_short | Effect of microplastics on nasal and gut microbiota of high-exposure population: Protocol for an observational cross-sectional study |
title_sort | effect of microplastics on nasal and gut microbiota of high-exposure population: protocol for an observational cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410575/ https://www.ncbi.nlm.nih.gov/pubmed/36042641 http://dx.doi.org/10.1097/MD.0000000000030215 |
work_keys_str_mv | AT zhangxiyu effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT heyuchi effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT xieziyan effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT pengsihan effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT xiechunguang effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT wangheting effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT liulu effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT kangjian effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT yuanhaipo effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy AT liuya effectofmicroplasticsonnasalandgutmicrobiotaofhighexposurepopulationprotocolforanobservationalcrosssectionalstudy |