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Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer

The objective of this study is to explore the prognostic factors of double primary cancer patients with lung cancer as the first primary cancer (FPC). The Surveillance, Epidemiology, and End Results (SEER) database is a database established by the National Institutes of Research for cancer registrat...

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Autores principales: Hu, Bin, Chen, Wanjiao, Xu, Ningjie, Lv, Jiarong, Sun, Shifang, Mai, Yifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410580/
https://www.ncbi.nlm.nih.gov/pubmed/36042670
http://dx.doi.org/10.1097/MD.0000000000030173
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author Hu, Bin
Chen, Wanjiao
Xu, Ningjie
Lv, Jiarong
Sun, Shifang
Mai, Yifeng
author_facet Hu, Bin
Chen, Wanjiao
Xu, Ningjie
Lv, Jiarong
Sun, Shifang
Mai, Yifeng
author_sort Hu, Bin
collection PubMed
description The objective of this study is to explore the prognostic factors of double primary cancer patients with lung cancer as the first primary cancer (FPC). The Surveillance, Epidemiology, and End Results (SEER) database is a database established by the National Institutes of Research for cancer registration purposes, which collects relatively complete demographic characteristics and clinical data for assessing the epidemiological characteristics of cancer worldwide. Clinical data on patients with a clear histopathological diagnosis of double primary with lung cancer as the FPC were identified and collected from the SEER database from 2010 to 2015. Survival curves were plotted by Kaplan–Meier survival analysis. Independent prognostic factors of patients were analyzed by COX proportional risk model. Clinical data were collected from a total of 9306 patients, including 6516 patients in the modeling group and 2790 patients in the validation group. When we retrieved that the FPC was lung cancer, we found that the most common site of the second primary cancer was located in the respiratory system (54.0%). In addition, the most common site of first primary lung cancer in patients with double primary cancer was the right upper lobe (33.3%). A total of 14 independent prognostic factors were included, and the constructed survival nomogram had high accuracy and clinical applicability. The nomogram established in this study can help to raise awareness of clinical workers and the importance of such diseases, and guide the treatment and follow-up strategies.
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spelling pubmed-94105802022-08-26 Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer Hu, Bin Chen, Wanjiao Xu, Ningjie Lv, Jiarong Sun, Shifang Mai, Yifeng Medicine (Baltimore) Research Article The objective of this study is to explore the prognostic factors of double primary cancer patients with lung cancer as the first primary cancer (FPC). The Surveillance, Epidemiology, and End Results (SEER) database is a database established by the National Institutes of Research for cancer registration purposes, which collects relatively complete demographic characteristics and clinical data for assessing the epidemiological characteristics of cancer worldwide. Clinical data on patients with a clear histopathological diagnosis of double primary with lung cancer as the FPC were identified and collected from the SEER database from 2010 to 2015. Survival curves were plotted by Kaplan–Meier survival analysis. Independent prognostic factors of patients were analyzed by COX proportional risk model. Clinical data were collected from a total of 9306 patients, including 6516 patients in the modeling group and 2790 patients in the validation group. When we retrieved that the FPC was lung cancer, we found that the most common site of the second primary cancer was located in the respiratory system (54.0%). In addition, the most common site of first primary lung cancer in patients with double primary cancer was the right upper lobe (33.3%). A total of 14 independent prognostic factors were included, and the constructed survival nomogram had high accuracy and clinical applicability. The nomogram established in this study can help to raise awareness of clinical workers and the importance of such diseases, and guide the treatment and follow-up strategies. Lippincott Williams & Wilkins 2022-08-26 /pmc/articles/PMC9410580/ /pubmed/36042670 http://dx.doi.org/10.1097/MD.0000000000030173 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hu, Bin
Chen, Wanjiao
Xu, Ningjie
Lv, Jiarong
Sun, Shifang
Mai, Yifeng
Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
title Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
title_full Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
title_fullStr Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
title_full_unstemmed Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
title_short Clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
title_sort clinical characteristics and cancer-specific survival analysis of double primary cancer patients with lung cancer as the first primary cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410580/
https://www.ncbi.nlm.nih.gov/pubmed/36042670
http://dx.doi.org/10.1097/MD.0000000000030173
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