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Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study

Recently, the prevalence of colorectal cancer has been increasing in Korea. Several studies have reported that adenomatous polyps, known as precancerous lesions, are associated with increased blood insulin levels. The principal objective of the present study was to examine the correlation between in...

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Autores principales: Shin, Hwang Sik, Cho, Yong Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410615/
https://www.ncbi.nlm.nih.gov/pubmed/36042665
http://dx.doi.org/10.1097/MD.0000000000030200
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author Shin, Hwang Sik
Cho, Yong Jin
author_facet Shin, Hwang Sik
Cho, Yong Jin
author_sort Shin, Hwang Sik
collection PubMed
description Recently, the prevalence of colorectal cancer has been increasing in Korea. Several studies have reported that adenomatous polyps, known as precancerous lesions, are associated with increased blood insulin levels. The principal objective of the present study was to examine the correlation between insulin levels and colon polyps in subjects without a history of diabetes or colorectal cancer. From January 2, 2018 to December 31, 2019, 3277 adults who visited the University Hospital Health Examination Center and underwent colonoscopy were included in this study. Insulin, glycated hemoglobin (HbA1c), and fasting blood glucose levels were measured, and past medical history, alcohol consumption, smoking, and physical activity were assessed using self-administered questionnaires. Among the 3277 subjects, the prevalence of adenomatous and nonadenomatous lesions were 22.2% and 11.5%, respectively. The mean values of insulin, HbA1c, and fasting blood glucose were significantly increased in the adenomatous and nonadenomatous polyp groups compared to the normal group. Logistic regression analysis showed that the risk of adenoma (odds ratio [OR] 1.483; 95% confidence interval [CI], 1.170–1.878) and nonadenomatous polyps (OR 1.415; 95% CI, 1.038–1.929) were increased in the high insulin level group (≥7.36 uIU/mL), and only the risk of adenoma (OR 1.312; 95% CI, 1.003–1.718) was significantly higher after adjustment for disturbance variables. This study suggests that an increase in insulin levels is a significant risk factor for colon adenoma.
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spelling pubmed-94106152022-08-26 Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study Shin, Hwang Sik Cho, Yong Jin Medicine (Baltimore) Research Article Recently, the prevalence of colorectal cancer has been increasing in Korea. Several studies have reported that adenomatous polyps, known as precancerous lesions, are associated with increased blood insulin levels. The principal objective of the present study was to examine the correlation between insulin levels and colon polyps in subjects without a history of diabetes or colorectal cancer. From January 2, 2018 to December 31, 2019, 3277 adults who visited the University Hospital Health Examination Center and underwent colonoscopy were included in this study. Insulin, glycated hemoglobin (HbA1c), and fasting blood glucose levels were measured, and past medical history, alcohol consumption, smoking, and physical activity were assessed using self-administered questionnaires. Among the 3277 subjects, the prevalence of adenomatous and nonadenomatous lesions were 22.2% and 11.5%, respectively. The mean values of insulin, HbA1c, and fasting blood glucose were significantly increased in the adenomatous and nonadenomatous polyp groups compared to the normal group. Logistic regression analysis showed that the risk of adenoma (odds ratio [OR] 1.483; 95% confidence interval [CI], 1.170–1.878) and nonadenomatous polyps (OR 1.415; 95% CI, 1.038–1.929) were increased in the high insulin level group (≥7.36 uIU/mL), and only the risk of adenoma (OR 1.312; 95% CI, 1.003–1.718) was significantly higher after adjustment for disturbance variables. This study suggests that an increase in insulin levels is a significant risk factor for colon adenoma. Lippincott Williams & Wilkins 2022-08-26 /pmc/articles/PMC9410615/ /pubmed/36042665 http://dx.doi.org/10.1097/MD.0000000000030200 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Shin, Hwang Sik
Cho, Yong Jin
Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study
title Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study
title_full Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study
title_fullStr Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study
title_full_unstemmed Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study
title_short Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study
title_sort insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: a retrospective, hospital-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410615/
https://www.ncbi.nlm.nih.gov/pubmed/36042665
http://dx.doi.org/10.1097/MD.0000000000030200
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